Increasing SR Ca uptake: A double‐edge sword

2022 ◽  
Author(s):  
Carlos A. Valverde ◽  
Alicia Mattiazzi
Keyword(s):  
Double Edge ◽  
Ca Uptake ◽  
Double Edge Sword

scholarly journals HDAC inhibitors: Double edge sword for TRAIL cancer therapy?

2005 ◽  
Vol 4 (10) ◽  
pp. 1113-1115 ◽  
Author(s):  
Simone Fulda ◽  
Klaus-Michael Debatin
Keyword(s):  
Cancer Therapy ◽  
Hdac Inhibitors ◽  
Double Edge ◽  
Double Edge Sword

WITHDRAWN: Dendritic cells: A double-edge sword in atherosclerotic inflammation

2013 ◽  
Author(s):  
Dimitry A. Chistiakov ◽  
Igor A. Sobenin ◽  
Alexander N. Orekhov ◽  
Yuri V. Bobryshev
Keyword(s):  
Dendritic Cells ◽  
Double Edge ◽  
Double Edge Sword

Protected Areas as a Double Edge Sword: An Analysis of Factors Driving Urbanization in Their Surroundings

2021 ◽  
Author(s):  
Alberto Gonzalez Garcia ◽  
Ignacio Palomo ◽  
Manuel Arboledas ◽  
José A. González ◽  
Marta Múgica ◽  
...  
Keyword(s):  
Protected Areas ◽  
Double Edge ◽  
Double Edge Sword

scholarly journals Double-edge sword roles of iron in driving energy production versus instigating ferroptosis

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Shuping Zhang ◽  
Wei Xin ◽  
Gregory J. Anderson ◽  
Ruibin Li ◽  
Ling Gao ◽  
...  
Keyword(s):  
Fenton Reaction ◽  
Energy Production ◽  
Iron Homeostasis ◽  
Regulated Cell Death ◽  
Double Edge ◽  
Double Edge Sword ◽  
Novel Interactions ◽  
Metabolic Activities ◽  
Species Production

AbstractIron is vital for many physiological functions, including energy production, and dysregulated iron homeostasis underlies a number of pathologies. Ferroptosis is a recently recognized form of regulated cell death that is characterized by iron dependency and lipid peroxidation, and this process has been reported to be involved in multiple diseases. The mechanisms underlying ferroptosis are complex, and involve both well-described pathways (including the iron-induced Fenton reaction, impaired antioxidant capacity, and mitochondrial dysfunction) and novel interactions linked to cellular energy production. In this review, we examine the contribution of iron to diverse metabolic activities and their relationship to ferroptosis. There is an emphasis on the role of iron in driving energy production and its link to ferroptosis under both physiological and pathological conditions. In conclusion, excess reactive oxygen species production driven by disordered iron metabolism, which induces Fenton reaction and/or impairs mitochondrial function and energy metabolism, is a key inducer of ferroptosis.

‘The day after’

2017 ◽  
Vol 24 (2) ◽  
pp. 158-174
Author(s):  
Phedon Nicolaides
Keyword(s):  
Member State ◽  
Regulatory System ◽  
Partial Solution ◽  
Double Edge ◽  
Domestic Legislation ◽  
Double Edge Sword ◽  
Copy And Paste ◽  
Article 50 ◽  
The Uk ◽  
The Eu

The purpose of the two-year rule in Article 50 TEU is to prevent the remaining Member States from delaying the exit of the withdrawing Member State through stalling tactics. This article argues that the two-year period is a double-edge sword. It affords very little time to the withdrawing Member State to adjust its domestic legislation, regulatory system and administrative structure to be able to function effectively on the day after exit from the EU. The UK’s Great Repeal Bill proposes a ‘copy and paste’ approach. However, this approach is only a partial solution to the problem of the ‘exit-induced’ legal lacuna. With the use of two case studies, the article demonstrates that the UK will have to establish new regulatory procedures and redefine EU concepts inserted in national law. The UK will ‘regain control’ but will have to follow EU practice. At some point in the future it will also encounter the dilemma of diverging from EU practice and creating two sets of compliance standards for its companies.

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