scholarly journals Functional expression of TMEM16A in taste bud cells

2021 ◽  
Author(s):  
Domenico M. Guarascio ◽  
Kevin Y. Gonzalez‐Velandia ◽  
Andres Hernandez‐Clavijo ◽  
Anna Menini ◽  
Simone Pifferi
Keyword(s):  
Functional Expression ◽  
Taste Bud ◽  
Taste Bud Cells

scholarly journals Functional expression of ionotropic purinergic receptors on mouse taste bud cells

2007 ◽  
Vol 584 (2) ◽  
pp. 473-488 ◽  
Author(s):  
Ryotaro Hayato ◽  
Yoshitaka Ohtubo ◽  
Kiyonori Yoshii
Keyword(s):  
Purinergic Receptors ◽  
Functional Expression ◽  
Taste Bud ◽  
Mouse Taste ◽  
Taste Bud Cells

Some Observations on Changes in Denervated Taste Buds of Circumvallate Papillae of Rabbits

1969 ◽  
Vol 27 ◽  
pp. 308-309
Author(s):  
Sunao Fujimoto ◽  
Raymond G. Murray ◽  
Assia Murray
Keyword(s):  
Taste Buds ◽  
Taste Bud ◽  
Cell Type ◽  
Dark Cells ◽  
Type Iii ◽  
Circumvallate Papillae ◽  
Taste Bud Cells ◽  
Light Cells

Taste bud cells in circumvallate papillae of rabbit have been classified into three groups: dark cells; light cells; and type III cells. Unilateral section of the 9th nerve distal to the petrosal ganglion was performed in 18 animals, and changes of each cell type in the denervated buds were observed from 6 hours to 10 days after the operation.Degeneration of nerves is evident at 12 hours (Fig. 1) and by 2 days, nerves are completely lacking in the buds. Invasion by leucocytes into the buds is remarkable from 6 to 12 hours but then decreases. Their extrusion through the pore is seen. Shrinkage and disturbance in arrangement of cells in the buds can be seen at 2 days. Degenerated buds consisting of a few irregular cells and remnants of degenerated cells are present at 4 days, but buds apparently normal except for the loss of nerve elements are still present at 6 days.

scholarly journals Does intervention with GLP-1 receptor agonist semaglutide modulate perception of sweet taste in women with obesity: study protocol of a randomized, single-blinded, placebo-controlled clinical trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Mojca Jensterle ◽  
Simona Ferjan ◽  
Tadej Battelino ◽  
Jernej Kovač ◽  
Saba Battelino ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Neural Response ◽  
Taste Perception ◽  
Taste Bud ◽  
Controlled Clinical Trial ◽  
Food Cues ◽  
Link Type ◽  
Visual Food Cues ◽  
Taste Bud Cells

Abstract Background Preclinical studies demonstrated that glucagon-like peptide 1 (GLP-1) is locally synthesized in taste bud cells and that GLP-1 receptor exists on the gustatory nerves in close proximity to GLP-1-containing taste bud cells. This local paracrine GLP-1 signalling seems to be specifically involved in the perception of sweets. However, the role of GLP-1 in taste perception remains largely unaddressed in clinical studies. Whether any weight-reducing effects of GLP-1 receptor agonists are mediated through the modulation of taste perception is currently unknown. Methods and analysis This is an investigator-initiated, randomized single-blind, placebo-controlled clinical trial. We will enrol 30 women with obesity and polycystic ovary syndrome (PCOS). Participants will be randomized in a 1:1 ratio to either semaglutide 1.0 mg or placebo for 16 weeks. The primary endpoints are alteration of transcriptomic profile of tongue tissue as changes in expression level from baseline to follow-up after 16 weeks of treatment, measured by RNA sequencing, and change in taste sensitivity as detected by chemical gustometry. Secondary endpoints include change in neural response to visual food cues and to sweet-tasting substances as assessed by functional MRI, change in body weight, change in fat mass and change in eating behaviour and food intake. Discussion This is the first study to investigate the role of semaglutide on taste perception, along with a neural response to visual food cues in reward processing regions. The study may identify the tongue and the taste perception as a novel target for GLP-1 receptor agonists. Ethics and disseminations The study has been approved by the Slovene National Medical Ethics Committee and will be conducted in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines. Results will be submitted for publication in an international peer-reviewed scientific journal. Trial registration ClinicalTrials.govNCT04263415. Retrospectively registered on 10 February 2020

Voltage-gated currents of taste bud cells in infant mice

2007 ◽  
Vol 58 ◽  
pp. S217
Author(s):  
Masafumi Iwamoto ◽  
Yoshitaka Ohtubo ◽  
Kiyonori Yoshii
Keyword(s):  
Taste Bud ◽  
Voltage Gated ◽  
Taste Bud Cells

Expression of Neurotrophic Factors and Their Receptors in Rat Posterior Taste Bud Cells

2014 ◽  
Vol 39 (2) ◽  
pp. 107-114
Author(s):  
Dong-Il Park ◽  
◽  
Ki-Myung Chung ◽  
Young-Kyung Cho ◽  
Kyung-Nyun Kim
Keyword(s):  
Neurotrophic Factors ◽  
Taste Bud ◽  
Taste Bud Cells

scholarly journals Spilanthol Enhances Sensitivity to Sodium in Mouse Taste Bud Cells

2018 ◽  
Vol 44 (2) ◽  
pp. 91-103 ◽  
Author(s):  
Jiang Xu ◽  
Brian C Lewandowski ◽  
Toshio Miyazawa ◽  
Yasutaka Shoji ◽  
Karen Yee ◽  
...  
Keyword(s):  
Taste Bud ◽  
Mouse Taste ◽  
Taste Bud Cells
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