Mode of passive heating differentially modifies cerebral hemodynamics: Potential implications on heat therapy

2021 ◽  
Author(s):  
Morgan L. Worley ◽  
Emma L. Reed ◽  
Jessica A. Freemas ◽  
Christopher L. Chapman
2021 ◽  
Vol 130 (1) ◽  
pp. 1-9
Author(s):  
James J. McCormick ◽  
Karol Dokladny ◽  
Pope L. Moseley ◽  
Glen P. Kenny

Autophagy is a crucial cell survival mechanism that involves the degradation and recycling of old or damaged organelles and proteins to maintain cellular homeostasis. Impairments in autophagy are central to the pathogenesis of many conditions including metabolic and neurodegenerative disorders, cardiovascular and pulmonary diseases, diabetes, and aging. Although various pharmacological agents may be able to stimulate autophagic function, to our knowledge, few interventions exist that have been deemed safe and effective in humans. An emerging body of evidence suggests that targeting the autophagic pathway via passive heating (heat therapy) may stimulate autophagic function. Therefore, the primary focus of the present review is to analyze the mechanisms in which passive heating induces autophagy as defined by in vitro and in vivo (animal and human) models. Our secondary focus is to examine the implications of utilizing passive heating to restore dysfunctional autophagy in chronic disease and aging. Finally, we discuss potential therapeutic strategies to implement passive heating to stimulate autophagic function in humans.


2006 ◽  
Vol 210 (S 5) ◽  
Author(s):  
H Zotter ◽  
B Urlesberger ◽  
R Kerbl ◽  
G Pichler ◽  
W Müller

1991 ◽  
Vol 17 (3-4) ◽  
pp. 128-132 ◽  
Author(s):  
Heike Rabe ◽  
Gerhard Jorch

Hypertension ◽  
2017 ◽  
Vol 69 (4) ◽  
pp. 712-720 ◽  
Author(s):  
Chang-Yang Xing ◽  
Takashi Tarumi ◽  
Rutger L. Meijers ◽  
Marcel Turner ◽  
Justin Repshas ◽  
...  

Energies ◽  
2021 ◽  
Vol 14 (7) ◽  
pp. 2023
Author(s):  
Ruixin Li ◽  
Yiwan Zhao ◽  
Gaochong Lv ◽  
Weilin Li ◽  
Jiayin Zhu ◽  
...  

Near-wall microenvironment of a building refers to parameters such as wind speed, temperature, relative humidity, solar radiation near the building’s façade, etc. The distribution of these parameters on the building façade shows a certain variation based on changes in height. As a technology of passive heating and ventilation, the effectiveness of this application on heat collection wall is significantly affected by the near-wall microclimate, which is manifested by the differences, and rules of the thermal process of the components present at different elevations. To explore the feasibility and specificity of this application of heat collection wall in high-rise buildings, this study uses three typical high-rise buildings from Zhengzhou, China, as research buildings. Periodic measurements of the near-wall microclimate during winter and summer were carried out, and the changing rules of vertical and horizontal microclimate were discussed in detail. Later, by combining these measured data with numerical method, thermal process and performance of heat collection wall based on increasing altitude were quantitatively analyzed through numerical calculations, and the optimum scheme for heat collection wall components was summarized to provide a theoretical basis for the structural design of heat-collecting wall in high-rise buildings.


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