scholarly journals Involvement of TRPC5 channels, inwardly rectifying K + channels, PLCβ and PIP 2 in vasopressin‐mediated excitation of medial central amygdala neurons

2021 ◽  
Author(s):  
Cody A. Boyle ◽  
Binqi Hu ◽  
Kati L. Quaintance ◽  
Saobo Lei
Keyword(s):  
Central Amygdala ◽  
K Channels ◽  
Inwardly Rectifying ◽  
Trpc5 Channels

K+ Channels of Müller Glial Cells in Retinal Disorders

2018 ◽  
Vol 17 (4) ◽  
pp. 255-260 ◽  
Author(s):  
Feng Gao ◽  
Lin-Jie Xu ◽  
Yuan Zhao ◽  
Xing-Huai Sun ◽  
Zhongfeng Wang
Keyword(s):  
Müller Cells ◽  
Major Type ◽  
Delayed Rectifier ◽  
Muller Cells ◽  
Bkca Channels ◽  
K Channels ◽  
Functional Changes ◽  
Physiological Properties ◽  
Retinal Disorders ◽  
Inwardly Rectifying

Background & Objective: Müller cell is the major type of glial cell in the vertebrate retina. Müller cells express various types of K+ channels, such as inwardly rectifying K+ (Kir) channels, big conductance Ca2+-activated K+ (BKCa) channels, delayed rectifier K+ channels (KDR), and transient A-type K+ channels. These K+ channels play important roles in maintaining physiological functions of Müller cells. Under some retinal pathological conditions, the changed expression and functions of K+ channels may contribute to retinal pathogenesis. Conclusion: In this article, we reviewed the physiological properties of K+ channels in retinal Müller cells and the functional changes of these channels in retinal disorders.

scholarly journals Distinct inwardly rectifying K+ channels mediate agonist-inhibition of hormone secretion between α and β cells of pancreatic islet

1999 ◽  
Vol 79 ◽  
pp. 92
Author(s):  
Yukiko Yoshimoto ◽  
Yoshiyuki Horio ◽  
Yuji Fukuyama ◽  
Atsushi Inanobe ◽  
Uchida Wataru ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Hormone Secretion ◽  
Β Cells ◽  
K Channels ◽  
Inwardly Rectifying

Detergents, dimeric G beta gamma, and eicosanoid pathways to muscarinic atrial K+ channels

1990 ◽  
Vol 258 (5) ◽  
pp. H1507-H1514 ◽  
Author(s):  
A. Yatani ◽  
K. Okabe ◽  
L. Birnbaumer ◽  
A. M. Brown
Keyword(s):  
Cold Spring Harbor ◽  
K Channel ◽  
Direct Effects ◽  
K Channels ◽  
Nonspecific Effects ◽  
Gamma Subunits ◽  
Cold Spring ◽  
Inwardly Rectifying ◽  
Channel Currents ◽  
Zwitterionic Detergent

Control experiments for the direct effects of G protein beta gamma-subunits (G beta gamma) on muscarinic atrial K+ channel [K+ (ACh)] currents have produced different results (Nature Lond. 327: 21-22, 1987; Nature Lond. 325: 296-297, 1987; Cold Spring Harbor Symp. Quant. Biol. 53: 365-373, 1989). A recent view is that stimulation is indirect via phospholipase by (PLA2) and arachidonic acid (AA) metabolites (Nature Lond. 337: 504-505, 1989). On reexamination we found that 1) the zwitterionic detergent 3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate (CHAPS) used to suspend beta gamma stimulates atrial K+ (ACh) currents by itself, and the effects are concentration and Mg2+ dependent; 2) CHAPS stimulates atrial ATP-sensitive K+ channel and inwardly rectifying K+ channel currents; 3) blockers of eicosanoid pathways have nonspecific effects on atrial K+, Ca2+, and Na+ channels. We have confirmed that detergent-free, hydrophilic G beta gamma-subunits inhibit K+ (ACh) currents. Stimulatory effects of dimeric G beta gamma could not be separated from stimulatory effects of detergent, and blockers of PLA2 or lipoxygenase pathways do not clearly establish the significance of these pathways to atrial K+ (ACh) currents.

The expression of G-protein-gated inwardly rectifying K+ channels GIRK1 and GIRK2 mRNAs in the supraoptic nucleus of the rat and possible role involved

Neuroreport ◽  
2001 ◽  
Vol 12 (5) ◽  
pp. 1007-1010 ◽  
Author(s):  
Jian-hong Li ◽  
Zhen-dong You ◽  
Chao-you Song ◽  
Chang-lin Lu ◽  
Cheng He
Keyword(s):  
G Protein ◽  
Supraoptic Nucleus ◽  
K Channels ◽  
Inwardly Rectifying

scholarly journals Inhibition of G protein-activated inwardly rectifying K+ channels by fluoxetine (Prozac)

2003 ◽  
Vol 138 (6) ◽  
pp. 1119-1128 ◽  
Author(s):  
Toru Kobayashi ◽  
Kazuo Washiyama ◽  
Kazutaka Ikeda
Keyword(s):  
G Protein ◽  
K Channels ◽  
Inwardly Rectifying
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