NMDA receptor membrane dynamics tunes the firing pattern of midbrain dopaminergic neurons

2021 ◽  
Author(s):  
Laetitia Etchepare ◽  
Hélène Gréa ◽  
Pauline Durand ◽  
Delphine Bouchet ◽  
Laurent Groc
Keyword(s):  
Nmda Receptor ◽  
Dopaminergic Neurons ◽  
Firing Pattern ◽  
Membrane Dynamics ◽  
Receptor Membrane ◽  
Midbrain Dopaminergic Neurons

scholarly journals A Dynamic Role for GABA Receptors on the Firing Pattern of Midbrain Dopaminergic Neurons

2010 ◽  
Vol 104 (1) ◽  
pp. 403-413 ◽  
Author(s):  
Collin J. Lobb ◽  
Charles J. Wilson ◽  
Carlos A. Paladini
Keyword(s):  
Nmda Receptor ◽  
Gaba Receptors ◽  
Dopaminergic Neurons ◽  
Firing Pattern ◽  
Activity Patterns ◽  
Burst Firing ◽  
Dynamic Clamp ◽  
Tonic Activity ◽  
Midbrain Dopaminergic Neurons

Dopaminergic neurons are subject to a significant background GABAergic input in vivo. The presence of this GABAergic background might be expected to inhibit dopaminergic neuron firing. However, dopaminergic neurons are not all silent but instead fire in single-spiking and burst firing modes. Here we present evidence that phasic changes in the tonic activity of GABAergic afferents are a potential extrinsic mechanism that triggers bursts and pauses in dopaminergic neurons. We find that spontaneous single-spiking is more sensitive to activation of GABA receptors than phasic N-methyl-d-aspartate (NMDA)-mediated burst firing in rat slices (P15–P31). Because tonic activation of GABAA receptors has previously been shown to suppress burst firing in vivo, our results suggest that the activity patterns seen in vivo are the result of a balance between excitatory and inhibitory conductances that interact with the intrinsic pacemaking currents observed in slices. Using the dynamic clamp technique, we applied balanced, constant NMDA and GABAA receptor conductances into dopaminergic neurons in slices. Bursts could be produced by disinhibition (phasic removal of the GABAA receptor conductance), and these bursts had a higher frequency than bursts produced by the same NMDA receptor conductance alone. Phasic increases in the GABAA receptor conductance evoked pauses in firing. In contrast to NMDA receptor, application of constant AMPA and GABAA receptor conductances caused the cell to go into depolarization block. These results support a bidirectional mechanism by which GABAergic inputs, in balance with NMDA receptor–mediated excitatory inputs, control the firing pattern of dopaminergic neurons.

NMDA receptor modulation of the pedunculopontine tegmental nucleus underlies the motivational drive for feeding induced by midbrain dopaminergic neurons

2019 ◽  
Vol 1715 ◽  
pp. 134-147
Author(s):  
Grażyna Jerzemowska ◽  
Karolina Plucińska ◽  
Aleksandra Piwka ◽  
Kacper Ptaszek ◽  
Magdalena Podlacha ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Dopaminergic Neurons ◽  
Pedunculopontine Tegmental Nucleus ◽  
Tegmental Nucleus ◽  
Receptor Modulation ◽  
Midbrain Dopaminergic Neurons

scholarly journals Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons

2015 ◽  
Vol 35 (31) ◽  
pp. 11144-11152 ◽  
Author(s):  
E. Piccart ◽  
N. A. Courtney ◽  
S. Y. Branch ◽  
C. P. Ford ◽  
M. J. Beckstead
Keyword(s):  
Dopaminergic Neurons ◽  
Dopamine Autoreceptor ◽  
Midbrain Dopaminergic Neurons
Sign in / Sign up

Export Citation Format

Share Document