scholarly journals Mitochondria: powerhouses of presynaptic plasticity

2021 ◽  
Author(s):  
Shobana Subramanian ◽  
Elizabeth A. Jonas
Keyword(s):  
Presynaptic Plasticity

scholarly journals Lights On for the Molecular Players of Presynaptic Plasticity

Neuron ◽  
2015 ◽  
Vol 86 (3) ◽  
pp. 603-604 ◽  
Author(s):  
Mathias A. Böhme ◽  
Stephan J. Sigrist
Keyword(s):  
Presynaptic Plasticity

scholarly journals MeCP2 Deficiency Disrupts Kainate-Induced Presynaptic Plasticity in the Mossy Fiber Projections in the Hippocampus

2019 ◽  
Vol 13 ◽  
Author(s):  
Maria Laura Bertoldi ◽  
Maria Ines Zalosnik ◽  
Maria Carolina Fabio ◽  
Susan Aja ◽  
German A. Roth ◽  
...  
Keyword(s):  
Mossy Fiber ◽  
Presynaptic Plasticity

scholarly journals Presynaptic MAST kinase controls opposing postsynaptic responses to convey stimulus valence in Caenorhabditis elegans

2020 ◽  
Vol 117 (3) ◽  
pp. 1638-1647 ◽  
Author(s):  
Shunji Nakano ◽  
Muneki Ikeda ◽  
Yuki Tsukada ◽  
Xianfeng Fei ◽  
Takamasa Suzuki ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Diacylglycerol Kinase ◽  
Inhibitory Response ◽  
Thermal Gradients ◽  
Postsynaptic Neuron ◽  
Presynaptic Neuron ◽  
Presynaptic Plasticity ◽  
Freely Behaving ◽  
Stimulus Valence ◽  
Thermal Stimuli

Presynaptic plasticity is known to modulate the strength of synaptic transmission. However, it remains unknown whether regulation in presynaptic neurons can evoke excitatory and inhibitory postsynaptic responses. We report here that the Caenorhabditis elegans homologs of MAST kinase, Stomatin, and Diacylglycerol kinase act in a thermosensory neuron to elicit in its postsynaptic neuron an excitatory or inhibitory response that correlates with the valence of thermal stimuli. By monitoring neural activity of the valence-coding interneuron in freely behaving animals, we show that the alteration between excitatory and inhibitory responses of the interneuron is mediated by controlling the balance of two opposing signals released from the presynaptic neuron. These alternative transmissions further generate opposing behavioral outputs necessary for the navigation on thermal gradients. Our findings suggest that valence-encoding interneuronal activity is determined by a presynaptic mechanism whereby MAST kinase, Stomatin, and Diacylglycerol kinase influence presynaptic outputs.

scholarly journals Author response: Frequency-dependent mobilization of heterogeneous pools of synaptic vesicles shapes presynaptic plasticity

2017 ◽  
Author(s):  
Frédéric Doussau ◽  
Hartmut Schmidt ◽  
Kevin Dorgans ◽  
Antoine M Valera ◽  
Bernard Poulain ◽  
...  
Keyword(s):  
Synaptic Vesicles ◽  
Author Response ◽  
Response Frequency ◽  
Frequency Dependent ◽  
Presynaptic Plasticity
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