scholarly journals Arterial carbon dioxide and bicarbonate rather than pH regulate cerebral blood flow in the setting of acute experimental metabolic alkalosis

2021 ◽  
Author(s):  
Hannah G. Caldwell ◽  
Connor A. Howe ◽  
Carter J. Chalifoux ◽  
Ryan L. Hoiland ◽  
Jay M.J.R. Carr ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Metabolic Alkalosis ◽  
Arterial Carbon Dioxide

Effect of arterial carbon dioxide tension on cerebral blood flow during deep hypothermia

Cryobiology ◽  
1978 ◽  
Vol 15 (6) ◽  
pp. 715 ◽  
Author(s):  
Y. Kawashima ◽  
H. Yoshikawa ◽  
I. Kosugi ◽  
K. Okada ◽  
T. Kitagaki ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Carbon Dioxide Tension ◽  
Deep Hypothermia ◽  
Arterial Carbon Dioxide Tension ◽  
Arterial Carbon Dioxide

scholarly journals Interaction between the respiratory system and cerebral blood flow regulation

2019 ◽  
Vol 127 (5) ◽  
pp. 1197-1205 ◽  
Author(s):  
Shigehiko Ogoh
Keyword(s):  
Carbon Dioxide ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Carbon Dioxide Concentration ◽  
Regulatory System ◽  
Chronic Obstructive ◽  
Cerebral Vasculature ◽  
Respiratory Dysfunction ◽  
Obstructive Pulmonary Disease ◽  
Arterial Carbon Dioxide

This review summarizes the interaction between the regulatory system of respiration and cerebral vasculature. Some clinical reports provide evidence for the association between these two physiological regulatory systems. Physiologically, arterial carbon dioxide concentration is mainly regulated by two feedback control systems: respiration and cerebral blood flow. In other words, both of these systems are sensitive to the same mediator, i.e., carbon dioxide, at a set point. In addition, respiratory dysfunction alters various physiological factors that affect the cerebral vasculature. Therefore, it is physiologically plausible that these systems are closely linked. The regulation of arterial carbon dioxide concentration affected by respiration and cerebral blood flow may be a key factor for a rise in the risk of brain disease in the patients with respiratory dysfunction. For example, the management of respiratory disease (e.g., patients with chronic obstructive pulmonary disease) and the use of prophylactic therapy are essential to reduce the risk of stroke.

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