scholarly journals Bugs, breathing and blood pressure: microbiota–gut–brain axis signalling in cardiorespiratory control in health and disease

2020 ◽  
Vol 598 (19) ◽  
pp. 4159-4179
Author(s):  
Karen M. O'Connor ◽  
Eric F. Lucking ◽  
John F. Cryan ◽  
Ken D. O'Halloran
Keyword(s):  
Blood Pressure ◽  
Cardiorespiratory Control ◽  
Health And Disease

scholarly journals Circadian Blood Pressure Rhythm in Cardiovascular and Renal Health and Disease

Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 868
Author(s):  
Jiayang Zhang ◽  
Ruoyu Sun ◽  
Tingting Jiang ◽  
Guangrui Yang ◽  
Lihong Chen
Keyword(s):  
Blood Pressure ◽  
Circadian Rhythm ◽  
Molecular Mechanisms ◽  
Current Understanding ◽  
Renal Outcomes ◽  
Circadian Blood Pressure ◽  
Health And Disease ◽  
The Relationship

Blood pressure (BP) follows a circadian rhythm, it increases on waking in the morning and decreases during sleeping at night. Disruption of the circadian BP rhythm has been reported to be associated with worsened cardiovascular and renal outcomes, however the underlying molecular mechanisms are still not clear. In this review, we briefly summarized the current understanding of the circadian BP regulation and provided therapeutic overview of the relationship between circadian BP rhythm and cardiovascular and renal health and disease.

scholarly journals Hydrogen sulfide: stench from the past as a mediator of the future

2016 ◽  
Vol 38 (5) ◽  
pp. 12-17 ◽  
Author(s):  
Jasmina Zivanovic ◽  
Milos R. Filipovic
Keyword(s):  
Blood Pressure ◽  
Hydrogen Sulfide ◽  
Human Body ◽  
The Past ◽  
Ability To Act ◽  
Signalling Molecule ◽  
Actual Mechanism ◽  
Growing Body ◽  
Health And Disease ◽  
Pharmacological Potential

The past decade has witnessed the discovery of hydrogen sulfide (H2S) as a new signalling molecule. Its ability to act as a neurotransmitter, regulator of blood pressure, immunomodulator or anti-apoptotic agent, together with its great pharmacological potential, is now well established. Notwithstanding the growing body of evidence showing the biological roles of H2S, the gap between these roles and the actual mechanism(s) behind these processes is getting larger. We propose a way that protein cysteine residues can be modified to form protein persulfides (P-SSH) and explain how this process is controlled in a physiologically relevant fashion. This article provides an overview of H2S signalling in the human body with particular emphasis on the latest discoveries regarding the mechanisms of protein persulfidation and depersulfidation, as well as about the biological reactivity of persulfides and their role in health and disease.

Parameters to Be Measured during Exercise

2018 ◽  
pp. 82-105
Author(s):  
Gregory S. Thomas ◽  
Myrvin H. Ellestad
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Myocardial Ischemia ◽  
Oxygen Uptake ◽  
Exercise Duration ◽  
Metabolic Equivalents ◽  
Include Blood Pressure ◽  
Electrocardiographic Changes ◽  
Health And Disease ◽  
Exercise Induced

The chapter Parameters to be Measured During Exercise reviews the physiologic changes with exercise which indicate health and disease. Key parameters include blood pressure, heart rate, electrocardiographic changes, exercise duration, maximum oxygen uptake (VO2max), and anaerobic threshold. An in-depth review and consensus estimate is provided to estimate metabolic equivalents (METs) achieved based on exercise duration on the Bruce and Ellestad protocols. Use of bipolar leads for detection of exercise induced myocardial ischemia is discussed, typified by CM5 which captures up to 90% of patients with an electrocardiographic manifestation of ischemia. Changes in murmurs that occur with exercise are reviewed; walk-through angina and chronotropic incompetence.

Differential cardiorespiratory control elicited by activation of ventral medullary sites in mice

2000 ◽  
Vol 89 (2) ◽  
pp. 437-444 ◽  
Author(s):  
F. P. Tolentino-Silva ◽  
M. A. Haxhiu ◽  
P. Ernsberger ◽  
S. Waldbaum ◽  
I. A. Dreshaj
Keyword(s):  
Blood Pressure ◽  
Adrenergic Receptors ◽  
Excitatory Amino Acid ◽  
Signal Transduction Pathway ◽  
Ventrolateral Medulla ◽  
Respiratory Drive ◽  
Breathing Frequency ◽  
Cardiorespiratory Control ◽  
Blood Pressure Responses ◽  
Stimulation Of

We studied the respiratory and blood pressure responses to chemical stimulation of two regions of the ventral brainstem in mice: the rostral and caudal ventrolateral medulla (RVLM and CVLM, respectively). Stimulation of the RVLM by microinjections of the excitatory amino acid l-glutamate induced increases in diaphragm activity and breathing frequency, elevation of blood pressure (BP), and a slight increase in heart rate (HR). However, activation of the CVLM induced a decrease in breathing frequency, mainly due to prolongation of expiratory time (Te), and hypotension associated with a slight slowing of HR. Because adrenergic mechanisms are known to participate in the control of respiratory timing, we examined the role of α2-adrenergic receptors in the RVLM region in mediating these inhibitory effects. The findings demonstrated that blockade of the α2-adrenergic receptors within the RVLM by prior microinjection of SKF-86466 (an α2-adrenergic receptor blocker) significantly reduced changes in Te induced by CVLM stimulation but had little effect on BP responses. These results indicate that, in mice, activation of the RVLM increases respiratory drive associated with an elevation of BP, but stimulation of CVLM induces prolongation of Te via an α2-adrenergic signal transduction pathway.

Nondipping Blood Pressure: Predictive or Reactive Failure of Renal Sodium Handling?

Physiology ◽  
2021 ◽  
Vol 36 (1) ◽  
pp. 21-34 ◽  
Author(s):  
Jessica R. Ivy ◽  
Matthew A. Bailey
Keyword(s):  
Blood Pressure ◽  
Pressure Control ◽  
Sodium Reabsorption ◽  
Nocturnal Sleep ◽  
Sodium Homeostasis ◽  
Increased Risk ◽  
Health And Disease ◽  
Renal Sodium Handling ◽  
Sodium Handling

Blood pressure follows a daily rhythm, dipping during nocturnal sleep in humans. Attenuation of this dip (nondipping) is associated with increased risk of cardiovascular disease. Renal control of sodium homeostasis is essential for long-term blood pressure control. Sodium reabsorption and excretion have rhythms that rely on predictive/circadian as well as reactive adaptations. We explore how these rhythms might contribute to blood pressure rhythm in health and disease.

scholarly journals Sex Differences in the Developmental Origins of Cardiovascular Disease

Physiology ◽  
2014 ◽  
Vol 29 (2) ◽  
pp. 122-132 ◽  
Author(s):  
Suttira Intapad ◽  
Norma B. Ojeda ◽  
John Henry Dasinger ◽  
Barbara T. Alexander
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Sex Differences ◽  
Cardiovascular Risk ◽  
Early Life ◽  
Experimental Models ◽  
Developmental Origins ◽  
Proof Of Concept ◽  
Increased Risk ◽  
Health And Disease

The Developmental Origins of Health and Disease (DOHaD) proposes that adverse events during early life program an increased risk for cardiovascular disease. Experimental models provide proof of concept but also indicate that insults during early life program sex differences in adult blood pressure and cardiovascular risk. This review will highlight the potential mechanisms that contribute to the etiology of sex differences in the developmental programming of cardiovascular disease.

American Society of Hypertension position paper: central blood pressure waveforms in health and disease

2016 ◽  
Vol 10 (1) ◽  
pp. 22-33 ◽  
Author(s):  
Raymond R. Townsend ◽  
Clive Rosendorff ◽  
Wilmer W. Nichols ◽  
David G. Edwards ◽  
Julio A. Chirinos ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Position Paper ◽  
Central Blood Pressure ◽  
Health And Disease ◽  
American Society

scholarly journals A reversal of fate : unravelling the role of central 5-HT in cardiorespiratory control in neonatal and adult rodents

2018 ◽  
Author(s):  
◽  
Jennifer Magnusson
Keyword(s):  
Blood Pressure ◽  
Physiological Role ◽  
Sudden Infant Death ◽  
Sudden Infant ◽  
Autonomic Tone ◽  
Neurogenic Hypertension ◽  
Cardiorespiratory Control ◽  
Arterial Blood ◽  
Lower Blood

We seek to address the extent to which a specific loss of 5-hydroxytryptamine (5-HT) affects the control of respiration, arterial blood pressure (ABP) and heart rate (HR) across vigilance-states based on existing evidence suggesting that 5-HT defects increase the risk for Sudden Infant Death Syndrome (SIDS) and neurogenic hypertension. SIDS is the leading cause of infant mortality between 1 month and 1 year of age, occurs during sleep, and up to 70% of all SIDS cases have at least one 5-HT system abnormality. Neonatal rodents lacking central 5-HT exhibit severe apneas, and a reduced ABP and HR. Central 5-HT has been implicated in the etiology of neurogenic hypertension, presumably due to projections of 5-HT neurons within the midline raphe to vagal and presympathetic regions of the brain. However, data from studies examining the specific role of central 5-HT function is conflicting or inconclusive. Neurogenic hypertension accounts for more than 90% of all hypertensive cases and the normal fall in ABP that occurs during non-rapid eye movement sleep is absent in some patients with hypertension. Understanding the mechanisms associated with the development of hypertension is critical not only to lower blood pressure, but to lower its associated cardiovascular events. The purpose of this dissertation is to examine the role of central 5-HT in the control of ABP during sleep and reveal, mechanistically, the physiological role of 5-HT in the autonomic control of ABP in neonatal and adult rodents. The overarching hypothesis for this dissertation is that central 5-HT is required for the maintenance of ABP and autonomic tone at rest in both neonatal and adult rodents.

scholarly journals Haitian Men’s Health and Health Seeking Behavior

2020 ◽  
Vol 3 (3) ◽  
pp. e1-e8
Author(s):  
Gabriel Paul ◽  
Judy Lewis ◽  
Bette Gebrian
Keyword(s):  
Blood Pressure ◽  
Health Care ◽  
High Blood Pressure ◽  
Care Provider ◽  
Men’S Health ◽  
Men's Health ◽  
Health Seeking ◽  
Health Seeking Behaviors ◽  
Health And Disease

The notion that earlier medical interventions result in better patient outcomes is a widely held assumption in the medical community that is supported by extensive research. However, the decision to seek medical care in a timely manner is complex, especially in low- and middle-income countries (LMICs). A significant number of deaths in LMICs result from conditions for which effective treatments are available, such as high blood pressure. In Haiti, the greater life expectancy for women compared to men (67 vs. 62) may be par-tially explained by investments into maternal and reproductive services; however, several other factors are likely contributing to this difference. Given the limited research on men’s health and care-seeking behaviors in Haiti, this study was conducted to investigate the factors that influence men’s health-seeking behaviors and overall knowledge of health and disease. The long-term goal of this research is to identify, and implement, effective interventions that promote primary disease prevention by positively influencing the health-seeking behaviors of Haitian men in Jérémie and the Grand’Anse. MethodsThis study was a cross-sectional survey. A structured questionnaire was used to conduct 115 in-depth inter-views with Haitian men recruited from five churches of different denominations equidistant from Jérémie, Haiti. Questions investigated factors pertaining to socioeconomic status, church involvement, household composition, awareness of family and own health, health-seeking behaviors, and levels of knowledge of health and disease. Each participant had the opportunity to receive a blood pressure reading, and health education sessions were conducted at the conclusion of the study. ResultsMean age was 48 years, average household size was six, and 48% were married. Sixteen percent of men reported having multiple occupations, with 83% engaging in manual labor. Sixty seven percent reported being the primary decision-makers for health care. Sixty three percent had seen a health care provider in the last year; however, 70% had not sought care when sick due to cost (54%) or perceived severity (35%). Men reported they knew an average of 2.2 illnesses or diseases, with HIV/AIDs (30%) and cancer (30%) being the most common. Fifty eight percent of men thought disease and illness are preventable, and 9% believed early care was required for successful treatment. The preferred method of receiving health care information among men included health care provider (HCP) (33%), hospitals (26%), community health workers (22%), church (18%), and radio (18%). Sixty four percent had their blood pressure taken within the past year, and 32% were told that it was high. Only three of the 25 men, who were told their BP was high, reported HTN as a chronic (long-term) disease. Of the 115 men who received a BP measurement as part of the study, 28% had high blood pressure readings (>130/90). ConclusionMen in the community of rural Jérémie, Haiti, have limited knowledge of illness and disease, which may stem from insufficient resources being allocated to their health care. The cumulative effect of this may have negatively influenced their understanding of chronic, yet life-threatening, conditions such as high blood pressure. Consequently, a greater emphasis on health education and healthy lifestyle choices could have a substantial impact on not only primary prevention, but early detection and management of diseases as well. Therefore, in order to improve the health of both the men and their family members in this community, novel and targeted approaches to disseminate important health information to these men should be further investigated and readily implemented.

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