scholarly journals Lower body negative pressure: a novel remedy for preserving the cerebrovasculature from gravitational stress

2020 ◽  
Vol 598 (19) ◽  
pp. 4149-4150
Author(s):  
Faria Sanjana ◽  
Theodore M. DeConne
Keyword(s):  
Negative Pressure ◽  
Lower Body Negative Pressure ◽  
Lower Body ◽  
Gravitational Stress

Construction of a lower body negative pressure chamber

2007 ◽  
Vol 31 (1) ◽  
pp. 76-81 ◽  
Author(s):  
Ben T. A. Esch ◽  
Jessica M. Scott ◽  
Darren E. R. Warburton
Keyword(s):  
Negative Pressure ◽  
Atmospheric Pressure ◽  
Lower Body Negative Pressure ◽  
Physiological Responses ◽  
Pressure Chamber ◽  
Orthostatic Tolerance ◽  
Lower Body ◽  
Important Research ◽  
Gravitational Stress ◽  
Design Plan

Lower body negative pressure (LBNP) is an established and important technique used to physiologically stress the human body, particularly the cardiovascular system. LBNP is most often used to simulate gravitational stress, but it has also been used to simulate hemorrhage, alter preload, and manipulate baroreceptors. During experimentation, the consequences of LBNP and the reflex increases in heart rate and blood pressure can be manipulated and observed in a well-controlled manner, thus making LBNP an important research tool. Numerous laboratories have developed LBNP devices for use in research settings, and a few devices are commercially available. However, it is often difficult for new users to find adequately described design plans. Furthermore, many available plans require sophisticated and expensive materials and/or technical support. Therefore, we have created an affordable design plan for a LBNP chamber. The purpose of this article was to share our design template with others. In particular, we hope that this information will be of use in academic and research settings. Our pressure chamber has been stress tested to 100 mmHg below atmospheric pressure and has been used successfully to test orthostatic tolerance and physiological responses to −50 mmHg.

scholarly journals Reviving lower body negative pressure as a countermeasure to prevent pathological vascular and ocular changes in microgravity

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Katie M. Harris ◽  
Lonnie G. Petersen ◽  
Tobias Weber
Keyword(s):  
Venous Thrombosis ◽  
Negative Pressure ◽  
Gap Analysis ◽  
Lower Body Negative Pressure ◽  
Future Research ◽  
Lower Body ◽  
Time Duration ◽  
Deep Space Exploration ◽  
Gravitational Stress ◽  
Long Time

AbstractMitigation of spaceflight-related pathologies such as spaceflight-associated neuro-ocular syndrome (SANS) and the recently discovered risk of venous thrombosis must happen before deep space exploration can occur. Lower body negative pressure (LBNP) can simulate gravitational stress during spaceflight that is likely to counteract SANS and venous thrombosis, but the ideal dose and method of delivery have yet to be determined. We undertook a review of current LBNP literature and conducted a gap analysis to determine the steps needed to adapt LBNP for in-flight use. We found that to use LBNP in flight, it must be adapted to long time duration/low pressure use that should be compatible with crew activities. A lack of understanding of the etiology of the pathologies that LBNP can counteract hinders the application of LBNP as a countermeasure during spaceflight. Future research should aim at filling the knowledge gaps outlined in this review.

scholarly journals Lower body negative pressure protects brain perfusion in aviation gravitational stress induced by push–pull manoeuvre

2020 ◽  
Vol 598 (15) ◽  
pp. 3173-3186 ◽  
Author(s):  
Changyang Xing ◽  
Xinpei Wang ◽  
Yuan Gao ◽  
Jiaxin Zhang ◽  
Yunnan Liu ◽  
...  
Keyword(s):  
Negative Pressure ◽  
Lower Body Negative Pressure ◽  
Brain Perfusion ◽  
Lower Body ◽  
Gravitational Stress

Neurohormonal responses to oscillatory lower body negative pressure in healthy subjects

2021 ◽  
Author(s):  
Akanksha Singh ◽  
Shival Srivastav ◽  
Kavita Yadav ◽  
Dinu S. Chandran ◽  
Ashok Kumar Jaryal ◽  
...  
Keyword(s):  
Negative Pressure ◽  
Healthy Subjects ◽  
Lower Body Negative Pressure ◽  
Lower Body

Bradykinin has no acute effect on the response of forearm blood flow to sympathetic stimulation in man

1990 ◽  
Vol 78 (4) ◽  
pp. 399-401 ◽  
Author(s):  
M. J. Cullen ◽  
J. R. Cockcroft ◽  
D. J. Webb
Keyword(s):  
Blood Flow ◽  
Angiotensin Ii ◽  
Negative Pressure ◽  
Enzyme Inhibitor ◽  
Lower Body Negative Pressure ◽  
Acute Effect ◽  
Acute Administration ◽  
Lower Body ◽  
Resistance Vessels ◽  
Sympathetic Responses

1. Six healthy male subjects received 0.9% (w/v) NaCl (saline) followed by incremental doses of bradykinin (1, 3 and 10 pmol/min), via the left brachial artery. Blood flow and the response of blood flow to lower-body negative pressure were measured in both forearms during infusion of saline and each dose of bradykinin. 2. Bradykinin produced a moderate and dose-dependent increase in blood flow in the infused, but not the non-infused, forearm. Lower-body negative pressure produced an approximately 15–20% reduction in blood flow in both forearms, and this response was unaffected by local infusion of bradykinin. 3. Bradykinin, in contrast to angiotensin II, had no acute effect on peripheral sympathetic responses to lower-body negative pressure. We conclude that, in forearm resistance vessels in man, withdrawal of angiotensin II, rather than accumulation of bradykinin, is likely to account for the attenuation of peripheral sympathetic responses after acute administration of a converting-enzyme inhibitor.

The impact of menopausal status on cardiac responses to exercise training and lower body negative pressure

Maturitas ◽  
2017 ◽  
Vol 103 ◽  
pp. 91
Author(s):  
Amanda Q.X. Nio ◽  
Eric J. Stöhr ◽  
Samantha Rogers ◽  
Rachel Mynors-Wallis ◽  
Jane M. Black ◽  
...  
Keyword(s):  
Exercise Training ◽  
Negative Pressure ◽  
Lower Body Negative Pressure ◽  
Menopausal Status ◽  
Lower Body ◽  
Cardiac Responses ◽  
The Impact
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