scholarly journals Muscle spindle function in muscular dystrophy: A potential target for therapeutic intervention

2020 ◽  
Vol 598 (8) ◽  
pp. 1433-1434
Author(s):  
Stylianos Papaioannou ◽  
Michael Dimitriou
Keyword(s):  
Muscular Dystrophy ◽  
Muscle Spindle ◽  
Therapeutic Intervention ◽  
Potential Target ◽  
Spindle Function

scholarly journals Impaired muscle spindle function in murine models of muscular dystrophy

2020 ◽  
Vol 598 (8) ◽  
pp. 1591-1609 ◽  
Author(s):  
Laura Gerwin ◽  
Sarah Rossmanith ◽  
Corinna Haupt ◽  
Jürgen Schultheiß ◽  
Heinrich Brinkmeier ◽  
...  
Keyword(s):  
Muscular Dystrophy ◽  
Muscle Spindle ◽  
Murine Models ◽  
Spindle Function

Abstract 1685: Genomics based studies of gastric tumors identify ICOS as potential target for therapeutic intervention

2018 ◽  
Author(s):  
Heather A. Hirsch ◽  
Jason Reeves ◽  
Tong Zi ◽  
Alexander Needham ◽  
Edward Stack ◽  
...  
Keyword(s):  
Therapeutic Intervention ◽  
Gastric Tumors ◽  
Potential Target

scholarly journals The effects of vibration-induced altered stretch reflex sensitivity on maximal motor unit firing properties

2019 ◽  
Vol 121 (6) ◽  
pp. 2215-2221 ◽  
Author(s):  
Alejandra Barrera-Curiel ◽  
Ryan J. Colquhoun ◽  
Jesus A. Hernandez-Sarabia ◽  
Jason M. DeFreitas
Keyword(s):  
Motor Unit ◽  
Muscle Spindle ◽  
Stretch Reflex ◽  
Muscle Spindles ◽  
Motor Unit Action Potential ◽  
Firing Rates ◽  
Motor Unit Firing ◽  
Firing Properties ◽  
Spindle Function ◽  
Voluntary Strength

It is well known that muscle spindles have a monosynaptic, excitatory connection with α-motoneurons. However, the influence of muscle spindles on human motor unit behavior during maximal efforts remains untested. It has also been shown that muscle spindle function, as assessed by peripheral reflexes, can be systematically manipulated with muscle vibration. Therefore, the purpose of this study was to analyze the effects of brief and prolonged vibration on maximal motor unit firing properties. A crossover design was used, in which each of the 24 participants performed one to three maximal knee extensions under three separate conditions: 1) control, 2) brief vibration that was applied during the contraction, and 3) after prolonged vibration that was applied for ~20 min before the contraction. Multichannel EMG was recorded from the vastus lateralis during each contraction and was decomposed into its constituent motor unit action potential trains. Surprisingly, an approximate 9% reduction in maximal voluntary strength was observed not only after prolonged vibration but also during brief vibration. In addition, both vibration conditions had a large, significant effect on firing rates (a decrease in the rates) and a small to moderate, nonsignificant effect on recruitment thresholds (a small increase in the thresholds). Therefore, vibration had a detrimental influence on both maximal voluntary strength and motor unit firing properties, which we propose is due to altered function of the stretch reflex pathway. NEW & NOTEWORTHY We used vibration to alter muscle spindle function and examined the vibration’s influence on maximal motor unit properties. We discovered that vibration had a detrimental influence on motor unit behavior and motor output by decreasing motor unit firing rates, increasing recruitment thresholds, which led to decreased maximal strength. We believe that understanding the role of muscle spindles during maximal contractions provides a deeper insight into motor control and sensorimotor integration.

scholarly journals GSK-3 as potential target for therapeutic intervention in cancer

Oncotarget ◽  
2014 ◽  
Vol 5 (10) ◽  
pp. 2881-2911 ◽  
Author(s):  
James A. McCubrey ◽  
Linda S. Steelman ◽  
Fred E. Bertrand ◽  
Nicole M. Davis ◽  
Melissa Sokolosky ◽  
...  
Keyword(s):  
Therapeutic Intervention ◽  
Potential Target

Muscle spindle function during movement

1980 ◽  
Vol 3 (11) ◽  
pp. 251-253 ◽  
Author(s):  
David Burke
Keyword(s):  
Muscle Spindle ◽  
Spindle Function
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