scholarly journals CaMKII activity contributes to homeometric autoregulation of the heart: A novel mechanism for the Anrep effect

2020 ◽  
Vol 598 (15) ◽  
pp. 3129-3153 ◽  
Author(s):  
Jan‐Christian Reil ◽  
Gert‐Hinrich Reil ◽  
Árpád Kovács ◽  
Vasco Sequeira ◽  
Mark T. Waddingham ◽  
...  
Keyword(s):  
Homeometric Autoregulation

scholarly journals Homeometric Autoregulation in the Heart

1960 ◽  
Vol 8 (5) ◽  
pp. 1077-1091 ◽  
Author(s):  
S. J. SARNOFF ◽  
J. H. MITCHELL ◽  
J. P. GILMORE ◽  
J. P. REMENSNYDER
Keyword(s):  
Homeometric Autoregulation

scholarly journals Interaction between afterload and contractility in the newborn heart: Evidence of homeometric autoregulation in the intact circulation

1995 ◽  
Vol 25 (6) ◽  
pp. 1428-1435 ◽  
Author(s):  
Robert Johannes Menno Klautz ◽  
David Frank Teitel ◽  
Paul Steendijk ◽  
Frank van Bel ◽  
Jan Baan
Keyword(s):  
Homeometric Autoregulation

Influence of aortic pressure-induced homeometric autoregulation on myocardial performance

1968 ◽  
Vol 214 (5) ◽  
pp. 1186-1192 ◽  
Author(s):  
RL Clancy ◽  
Graham TP ◽  
J Ross ◽  
EH Sonnenblick ◽  
E Braunwald
Keyword(s):  
Aortic Pressure ◽  
Myocardial Performance ◽  
Homeometric Autoregulation

Potassium changes in the heart during homeometric autoregulation and acetyl strophanthidin

1963 ◽  
Vol 34 (4) ◽  
pp. 440-451 ◽  
Author(s):  
Stanley J. Sarnoff ◽  
Joseph P. Gilmore ◽  
Jere H. Mitchell ◽  
John P. Remensnyder
Keyword(s):  
Homeometric Autoregulation

Impact of homeometric autoregulation using a stepwise change in heart rate on dP/dtmax and time to peak dP/dt with resynchronization therapy

EP Europace ◽  
2021 ◽  
Vol 23 (Supplement_3) ◽  
Author(s):  
H Odland ◽  
S Ross ◽  
LO Gammelsrud ◽  
R Cornelussen ◽  
E Kongsgard
Keyword(s):  
Heart Rate ◽  
Linear Models ◽  
Biventricular Pacing ◽  
Lateral Position ◽  
Resynchronization Therapy ◽  
Apical Position ◽  
Stepwise Change ◽  
Time To Peak ◽  
Marginal Means ◽  
Homeometric Autoregulation

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Norwegian South East heath Authorities Background We investigated the homeometric autoregulation utilizing a stepwise change in heart rate on dP/dtmax and time to peak dP/dt (Td) with biventricular pacing (BIVP) and the LV lead positioned in the apical, anterior and lateral positions. Pacing at low HR (LHR) and high heart rates (HHR) changes contractility through homeometric autoregulation (Bowditch effect) without changing the resynchronization itself. Purpose To determine the effect of a change in contractility through homeometric autoregulation on two different effect measures of resynchronization therapy. Methods Twenty-nine patients in heart failure with LBBB underwent CRT implantation with continuous LV pressure registration. The LV lead was first placed in either apical or anterior position followed by a permanent placement in a lateral position. Sequential BIVP pacing was performed for one minute, at a rate 10% above intrinsic heart rate (LHR = 75 ± 9bpm), before dP/dtmax measurements were recorded, and the sequence was repeated with pacing rate increased by 30% (HHR = 98 ± 11bpm). Td was defined as the time from pacemaker stimuli to peak dP/dt. Mixed linear models were used for statistics, numbers are estimated marginal means ± SEM. Significance was set at p < 0.05. Results DP/dtmax was higher with HHR in lateral position (1036 ± 41mmHg/s) than with LHR (933mmHg/s). The same was observed for all other lead positions. However, there was no difference between lateral position with LHR and apical position with HHR (930 ± 44mmHg/s). There were no differences in Td between LHR and HHR, but Td was shorter with BIVP in lateral position at pacing LHR (158 ± 4ms) and HHR (155 ± 4ms) than in all other positions. Overall dP/dtmax increased by 10% from LHR to HHR (888 ± 41mmHg/s vs. 980 ± 41 mmHg/s), while overall Td decreased by 2.4% from 168 ± 4ms to 164 ± 4ms. We found a linear relationship between Td and dP/dtmax (R = 0.7) with β=-0.07 that would indicate a 6ms reduction in Td going from LHR to HHR. The overall change in Td from LHR to HHR could therefore be attributed to the change in dP/dtmax. Conclusion Homeometric regulation does not influence Td, but Td is sensitive to changes in resynchronization and pacing lead position. Td is shorter with BIVP in lateral position at both high and low HR as would be expected from a biomarker of resynchronization. HR influences dP/dtmax so distinction between optimal and non-optimal positions using dP/dtmax may be difficult without knowledge of homeometric state.

scholarly journals Altered hetero- and homeometric autoregulation in the terminally failing human heart

2005 ◽  
Vol 7 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Klara Brixius ◽  
Hannes Reuter ◽  
Wilhelm Bloch ◽  
Robert H.G. Schwinger
Keyword(s):  
Human Heart ◽  
Homeometric Autoregulation

Improved contractile performance of right ventricle in response to increased RV afterload in newborn lamb

2000 ◽  
Vol 278 (1) ◽  
pp. H100-H105 ◽  
Author(s):  
Maartje de Vroomen ◽  
Robbert H. Lopes Cardozo ◽  
Paul Steendijk ◽  
Frank van Bel ◽  
Jan Baan
Keyword(s):  
Right Ventricle ◽  
Systolic Function ◽  
Systolic Pressure ◽  
Balloon Occlusion ◽  
Newborn Lamb ◽  
End Diastolic Volume ◽  
Volume Relation ◽  
The Right ◽  
Homeometric Autoregulation ◽  
Contractile Performance

Pulmonary hypertension results in an increased afterload for the right ventricle (RV). To determine the effects of this increased afterload on RV contractile performance, we examined RV performance before and during 4 h of partial balloon occlusion of the pulmonary artery and again after releasing the occlusion in nine newborn lambs. RV contractile performance was quantified by indexes derived from systolic RV pressure-volume relations obtained by a combined pressure-conductance catheter during inflow reduction. An almost twofold increase of end-systolic RV pressure (from 22 to 38 mmHg) was maintained during 4 h. Cardiac output (CO) (0.74 ± 0.08 l/min) and stroke volume (4.3 ± 0.4 ml) were maintained, whereas end-diastolic volume (7.9 ± 1.3 ml) did not change significantly during this period. RV systolic function improved substantially; the end-systolic pressure-volume relation shifted leftward indicated by a significantly decreased volume intercept (up to 70%), together with a slightly increased slope. In this newborn lamb model, maintenance of CO during increased RV afterload is not obtained by an increased end-diastolic volume (Frank-Starling mechanism). Instead, the RV maintains its output by improving contractile performance through homeometric autoregulation.

Ca2+-dependent heterometric and homeometric autoregulation in hypertrophied rat heart

1989 ◽  
Vol 256 (4) ◽  
pp. H1139-H1147
Author(s):  
D. G. Pawlush ◽  
T. I. Musch ◽  
R. L. Moore
Keyword(s):  
Positive Inotropic Effect ◽  
Myocardial Hypertrophy ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
Left Ventricular ◽  
Experimental Conditions ◽  
Rat Hearts ◽  
Surgically Induced ◽  
Homeometric Autoregulation ◽  
Functional Responsiveness

There is evidence to suggest that the alterations in cardiac function that accompany several forms of myocardial hypertrophy are due in part to desensitization of the heart to the positive inotropic effect of extracellular Ca2+ (Cae2+). In this study the heterometric and homeometric functional responsiveness of normal (SH) and hypertrophied (HYP) isolated working rat hearts was examined as a function of extracellular Ca2+ concentration [( Ca2+]e). Surgically induced renovascular hypertension was used to produce a 39% increase in left ventricular (LV) weight in HYP hearts relative to LV weights of SH hearts. The Cae2+ dependence of heterometric autoregulation was examined in SH and HYP hearts. At high left atrial filling pressures, HYP hearts were functionally less sensitive to changes in [Ca2+]e than were SH hearts; this difference appeared to be due to a preload-dependent increase in the functional sensitivity of SH hearts but not HYP hearts to changes in [Ca2+]e. In both SH and HYP hearts, a step increase in afterload resulted in a beat-by-beat increase in peak aortic outflow systolic pressure (AoP) independent of changes in LV diastolic pressure. Under our experimental conditions, the magnitude of this homeometric AoP increase (the Anrep effect) was similar in both SH and HYP hearts. The AoP increase occurred at a monoexponential rate (kHA) and was much faster in SH than in HYP hearts. Furthermore, KHA varied directly as a function of [Ca2+]e only in the SH hearts.

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