scholarly journals Dynamic magnetic resonance imaging provides insight into upper airway mechanics in obstructive sleep apnoea

2020 ◽  
Vol 598 (3) ◽  
pp. 431-432
Author(s):  
Michael J. Brennick
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Obstructive Sleep Apnoea ◽  
Upper Airway ◽  
Sleep Apnoea ◽  
Dynamic Magnetic Resonance Imaging ◽  
Resonance Imaging ◽  
Obstructive Sleep ◽  
Airway Mechanics ◽  
Insight Into

scholarly journals Effects of octreotide on sleep apnoea and tongue volume (magnetic resonance imaging) in patients with acromegaly

2004 ◽  
pp. 309-315 ◽  
Author(s):  
BL Herrmann ◽  
TE Wessendorf ◽  
W Ajaj ◽  
S Kahlke ◽  
H Teschler ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Obstructive Sleep Apnoea ◽  
Signal Intensity ◽  
Sleep Apnoea ◽  
Resonance Imaging ◽  
Obstructive Sleep ◽  
Igf I ◽  
Active Acromegaly ◽  
Tongue Volume

OBJECTIVES: Sleep apnoea has been consistently reported to occur in acromegaly. Both obstructive apnoeas, in which apnoeas are due to intermittent obstruction of the upper airways, as well as central apnoeas are known to occur. Because the relationship between disease activity and severity of sleep apnoea is currently unclear, we have performed a prospective study to address this issue. DESIGN AND METHODS: In 14 newly diagnosed patients with active acromegaly (eight females and six males; mean age 57+/-4 years; IGF-I 583+/-48 microg/l; GH 13.5+/-7.0 microg/l (means+/-s.e.m.)), tongue volume and signal intensity of the tongue were examined by magnetic resonance imaging and sleep apnoea was characterised by polysomnography before and after 6 months of treatment with octreotide acetate (Sandostatin LAR 10-30 mg every 4 weeks i.m.). RESULTS: The initial tongue volume was significantly higher in patients with acromegaly (151+/-9 ml; females 133+/-10 ml; males 172+/-10 ml) in comparison with the body mass index (BMI)- and age-matched healthy control group (97+/-5 ml, P<0.001; females 75+/-1 ml, P<0.001; males 120+/-3 ml, P<0.003). After treatment with octreotide, IGF-I was normalised within the age-adjusted normal range in 50% of the patients. In these patients, tongue volume significantly decreased (120+/-14 ml, P<0.05) in comparison with the persistent uncontrolled group of acromegalics (137+/-10 ml, P=not significant). Overall, tongue volume (128+/-8 ml, P<0.05) and the signal intensity ratio of the tongue decreased significantly after treatment with octreotide acetate (120+/-3 vs 105+/-3, P=0.003). The BMI-adjusted tongue volume correlated with IGF-I levels (r=0.60, P<0.002) and the disease duration (r=0.71, P=0.006). At baseline, 50% had obstructive sleep apnoea with a mean respiratory disturbance index (RDI) of >20/h (range 5.1-91.5) and no patient had central sleep apnoea. After 6 months of octreotide treatment, there was a 28+/-10% decrease in RDI. However, RDI did not correlate with IGF-I or GH levels, but correlated positively with BMI (r=0.58, P=0.001) and age (r=0.46, P=0.02). CONCLUSIONS: Obstructive sleep apnoea but not central sleep apnoea frequently occurs in patients with active acromegaly. Successful treatment with octreotide can decrease tongue volume, which may have benefits for coexisting sleep-disordered breathing.

scholarly journals Obstructive sleep apnoea severity and liver steatosis measured by magnetic resonance imaging

2019 ◽  
Vol 55 (1) ◽  
pp. 1901514
Author(s):  
Wojciech Trzepizur ◽  
Jérôme Boursier ◽  
Anna Berréhare ◽  
Marc Le Vaillant ◽  
Ramaroson Andriantsitohaina ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Obstructive Sleep Apnoea ◽  
Liver Steatosis ◽  
Sleep Apnoea ◽  
Resonance Imaging ◽  
Obstructive Sleep

scholarly journals Obesity, The Single Most Important Risk Factor for OSA: A Case Report

Pulse ◽  
2018 ◽  
Vol 10 (1) ◽  
pp. 38-41
Author(s):  
SMAA Mamun
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Clinical Symptoms ◽  
Upper Airway ◽  
Resonance Imaging ◽  
Cross Sectional ◽  
Airway Narrowing ◽  
Fat Deposits ◽  
Obstructive Sleep ◽  
Normal Controls

Obstructive sleep apnea (OSA) is characterized by repetitive airflow reduction caused by collapse of the upper airway during sleep in addition to daytime sleepiness, clinical symptoms include fatigue, insomnia, and snoring. The condition is associated with adverse clinical outcomes, including cardiovascular disease, hypertension, cognitive impairment, and metabolic abnormalities.1 Among the risk factors for OSA, obesity is probably the most important. Several studies have consistently found an association between increased body weight and risk of OSA. Tomographic scanned images have shown that obesity causes increased fatty deposits in the pharyngeal area.2 The deposits encroach on the airway and contribute to airway narrowing. Also, among obese patients as compared to normal controls, fat deposits appear to alter the shape of the upper airway without necessarily reducing the cross-sectional area. M. A. Ciscar et al used magnetic resonance imaging to investigate differences between obese and normal controls.2 Ultrafast magnetic resonance imaging was used to study the upper airway and surrounding soft tissue in 17 patients with OSA during wakefulness and sleep, and in eight healthy subjects whilst awake. Coronal sections of awake OSA patients showed elliptical-shaped airways with long axes that were oriented anteroposterior; normal controls had airways that were oriented transversely. Studies using computed tomography have produced similar results.14Pulse Vol.10 January-December 2017 p.38-41

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