scholarly journals Pushing and pulling with no end in sight! The role of cross‐talk between different forms of respiratory plasticity in modifying sleep apnoea

2019 ◽  
Vol 597 (15) ◽  
pp. 3789-3790 ◽  
Author(s):  
Jason H. Mateika ◽  
Gino S. Panza ◽  
Raichel Alex ◽  
Kenia Castillo
Keyword(s):  
Cross Talk ◽  
Sleep Apnoea ◽  
Respiratory Plasticity ◽  
Pushing And Pulling

scholarly journals Human intermittent hypoxia-induced respiratory plasticity is not caused by inflammation

2015 ◽  
Vol 46 (4) ◽  
pp. 1072-1083 ◽  
Author(s):  
Andrew E. Beaudin ◽  
Xavier Waltz ◽  
Matiram Pun ◽  
Katherine E. Wynne-Edwards ◽  
Sofia B. Ahmed ◽  
...  
Keyword(s):  
Intermittent Hypoxia ◽  
Sleep Apnoea ◽  
Double Blind ◽  
Healthy Humans ◽  
Cox Inhibitor ◽  
Obstructive Sleep ◽  
Tnf Α ◽  
Respiratory Plasticity ◽  
Cox 2

Ventilatory instability, reflected by enhanced acute hypoxic (AHVR) and hypercapnic (AHCVR) ventilatory responses is a fundamental component of obstructive sleep apnoea (OSA) pathogenesis. Intermittent hypoxia-induced inflammation is postulated to promote AHVR enhancement in OSA, although the role of inflammation in intermittent hypoxia-induced respiratory changes in humans has not been examined. Thus, this study assessed the role of inflammation in intermittent hypoxia-induced respiratory plasticity in healthy humans.In a double-blind, placebo-controlled, randomised crossover study design, 12 males were exposed to 6 h of intermittent hypoxia on three occasions. Prior to intermittent hypoxia exposures, participants ingested (for 4  days) either placebo or the nonsteroidal anti-inflammatory drugs indomethacin (nonselective cyclooxygenase (COX) inhibitor) and celecoxib (selective COX-2 inhibitor). Pre- and post-intermittent hypoxia resting ventilation, AHVR, AHCVR and serum concentration of the pro-inflammatory cytokine tumour necrosis factor (TNF)-α were assessed.Pre-intermittent hypoxia resting ventilation, AHVR, AHCVR and TNF-α concentrations were similar across all three conditions (p≥0.093). Intermittent hypoxia increased resting ventilation and the AHVR similarly across all conditions (p=0.827), while the AHCVR was increased (p=0.003) and TNF-α was decreased (p=0.006) with only selective COX-2 inhibition.These findings indicate that inflammation does not contribute to human intermittent hypoxia-induced respiratory plasticity. Moreover, selective COX-2 inhibition augmented the AHCVR following intermittent hypoxia exposure, suggesting that selective COX-2 inhibition could exacerbate OSA severity by increasing ventilatory instability.

The Role of Sensing Peptides in the Cross-talk between Microbiota and Human Cancer Cells

2018 ◽  
Vol 18 (18) ◽  
pp. 1567-1571
Author(s):  
Anna Lucia Tornesello ◽  
Luigi Buonaguro ◽  
Maria Lina Tornesello ◽  
Franco M. Buonaguro
Keyword(s):  
Cancer Cells ◽  
Cross Talk ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
The Cross

Role of the metabotropic P2Y4 receptor during hypoglycemia: cross talk with the ionotropic NMDAR1 receptor

2004 ◽  
Vol 300 (1) ◽  
pp. 149-158 ◽  
Author(s):  
Fabio Cavaliere ◽  
Susanna Amadio ◽  
Daniela F. Angelini ◽  
Giuseppe Sancesario ◽  
Giorgio Bernardi ◽  
...  
Keyword(s):  
Cross Talk ◽  
P2y4 Receptor

scholarly journals The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Kevin Boyé ◽  
Nadège Pujol ◽  
Isabel D Alves ◽  
Ya-Ping Chen ◽  
Thomas Daubon ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Cross Talk ◽  
Primary Brain Tumors

Obstructive sleep apnoea and the role of the dental team

BDJ ◽  
2020 ◽  
Vol 228 (9) ◽  
pp. 681-685
Author(s):  
Minnie Lyons-Coleman ◽  
Claire Bates ◽  
Sophy Barber
Keyword(s):  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Obstructive Sleep
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