scholarly journals 3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes

2018 ◽  
Vol 597 (2) ◽  
pp. 399-418 ◽  
Author(s):  
Xin Shen ◽  
Jonas den Brink ◽  
Yufeng Hou ◽  
Dylan Colli ◽  
Christopher Le ◽  
...  
Keyword(s):  
Cardiac Myocytes ◽  
Ryanodine Receptor ◽  
Receptor Localization ◽  
Rat Cardiac Myocytes

scholarly journals Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes

2009 ◽  
Vol 106 (52) ◽  
pp. 22275-22280 ◽  
Author(s):  
David Baddeley ◽  
Isuru D. Jayasinghe ◽  
Leo Lam ◽  
Sabrina Rossberger ◽  
Mark B. Cannell ◽  
...  
Keyword(s):  
Cardiac Myocytes ◽  
Ryanodine Receptor ◽  
Single Channel ◽  
Resolution Imaging ◽  
Rat Cardiac Myocytes ◽  
Receptor Distribution

Nanoscale analysis of ryanodine receptor clusters in dyadic couplings of rat cardiac myocytes

2015 ◽  
Vol 80 ◽  
pp. 45-55 ◽  
Author(s):  
Yufeng Hou ◽  
Isuru Jayasinghe ◽  
David J. Crossman ◽  
David Baddeley ◽  
Christian Soeller
Keyword(s):  
Cardiac Myocytes ◽  
Ryanodine Receptor ◽  
Receptor Clusters ◽  
Rat Cardiac Myocytes

scholarly journals cADP ribose and [Ca2+]iregulation in rat cardiac myocytes

2000 ◽  
Vol 279 (4) ◽  
pp. H1482-H1489 ◽  
Author(s):  
Y. S. Prakash ◽  
Mathur S. Kannan ◽  
Timothy F. Walseth ◽  
Gary C. Sieck
Keyword(s):  
Electrical Stimulation ◽  
Sarcoplasmic Reticulum ◽  
Confocal Microscopy ◽  
Real Time ◽  
Cardiac Myocytes ◽  
Ryanodine Receptor ◽  
Ventricular Myocytes ◽  
Adult Rat ◽  
Intracellular Ca ◽  
Rat Cardiac Myocytes

cADP ribose (cADPR)-induced intracellular Ca2+ concentration ([Ca2+]i) responses were assessed in acutely dissociated adult rat ventricular myocytes using real-time confocal microscopy. In quiescent single myocytes, injection of cADPR (0.1–10 μM) induced sustained, concentration-dependent [Ca2+]i responses ranging from 50 to 500 nM, which were completely inhibited by 20 μM 8-amino-cADPR, a specific blocker of the cADPR receptor. In myocytes displaying spontaneous [Ca2+]i waves, increasing concentrations of cADPR increased wave frequency up to ∼250% of control. In electrically paced myocytes (0.5 Hz, 5-ms duration), cADPR increased the amplitude of [Ca2+]i transients in a concentration-dependent fashion, up to 150% of control. Administration of 8-amino-cADPR inhibited both spontaneous waves as well as [Ca2+]i responses to electrical stimulation, even in the absence of exogenous cADPR. However, subsequent [Ca2+]i responses to 5 mM caffeine were only partially inhibited by 8-amino-cADPR. In contrast, even under conditions where ryanodine receptor (RyR) channels were blocked with ryanodine, high cADPR concentrations still induced an [Ca2+]i response. These results indicate that in cardiac myocytes, cADPR induces Ca2+ release from the sarcoplasmic reticulum through both RyR channels and via mechanisms independent of RyR channels.

scholarly journals Imaging of the Ryanodine Receptor Distribution in Rat Cardiac Myocytes with Optical Single Channel Resolution

2010 ◽  
Vol 98 (3) ◽  
pp. 296a ◽  
Author(s):  
David Baddeley ◽  
Isuru D. Jayasinghe ◽  
Leo Lam ◽  
Sabrina Rossberger ◽  
Mark B. Cannell ◽  
...  
Keyword(s):  
Cardiac Myocytes ◽  
Ryanodine Receptor ◽  
Single Channel ◽  
Rat Cardiac Myocytes ◽  
Receptor Distribution

Arginine Vasopressin Increases Nitric Oxide Synthesis in Cytokine-Stimulated Rat Cardiac Myocytes

Hypertension ◽  
1997 ◽  
Vol 30 (5) ◽  
pp. 1112-1120 ◽  
Author(s):  
Keiji Yamamoto ◽  
Uichi Ikeda ◽  
Koji Okada ◽  
Toshikazu Saito ◽  
Yasuhiro Kawahara ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cardiac Myocytes ◽  
Arginine Vasopressin ◽  
Nitric Oxide Synthesis ◽  
Rat Cardiac Myocytes

scholarly journals ICAM-1 expression induced by endothelins on rat cardiac myocytes and aortic endothelial cells

1997 ◽  
Vol 73 ◽  
pp. 46
Author(s):  
Yoko Hayasaki ◽  
Masatoshi Nakajima ◽  
Yoshinori Kitano ◽  
Takanori Iwasaki ◽  
Toshitake Shimamura ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cardiac Myocytes ◽  
Aortic Endothelial Cells ◽  
Rat Cardiac Myocytes ◽  
Aortic Endothelial

scholarly journals The cAMP binding protein Epac modulates Ca2+sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes

2007 ◽  
Vol 583 (2) ◽  
pp. 685-694 ◽  
Author(s):  
Laetitia Pereira ◽  
Mélanie Métrich ◽  
María Fernández-Velasco ◽  
Alexandre Lucas ◽  
Jérôme Leroy ◽  
...  
Keyword(s):  
Cardiac Myocytes ◽  
Binding Protein ◽  
Signalling Pathway ◽  
Calmodulin Kinase ◽  
Rat Cardiac Myocytes
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