scholarly journals Elevation of extracellular osmolarity improves signs of myotonia congenita in vitro : a preclinical animal study

2018 ◽  
Vol 597 (1) ◽  
pp. 225-235 ◽  
Author(s):  
Kerstin Hoppe ◽  
Sunisa Chaiklieng ◽  
Frank Lehmann‐Horn ◽  
Karin Jurkat‐Rott ◽  
Scott Wearing ◽  
...  
Keyword(s):  
Animal Study ◽  
Myotonia Congenita ◽  
Preclinical Animal Study

Novel self-expandable, stent-based transcatheter pulmonic valve: A preclinical animal study

2014 ◽  
Vol 173 (1) ◽  
pp. 74-79 ◽  
Author(s):  
Gi Beom Kim ◽  
Hong-Gook Lim ◽  
Yong Jin Kim ◽  
Eun Young Choi ◽  
Bo Sang Kwon ◽  
...  
Keyword(s):  
Animal Study ◽  
Pulmonic Valve ◽  
Preclinical Animal Study

Inhibitory activities of Cystoseira crinita sulfated polysaccharide on key enzymes related to diabetes and hypertension: in vitro and animal study

2016 ◽  
Vol 123 (1) ◽  
pp. 31-42 ◽  
Author(s):  
Amel Ben Gara ◽  
Rihab Ben Abdallah Kolsi ◽  
Neila Jardak ◽  
Rim Chaaben ◽  
Abdelfattah El-Feki ◽  
...  
Keyword(s):  
Animal Study ◽  
Sulfated Polysaccharide ◽  
Key Enzymes ◽  
Inhibitory Activities

New Thrombolytic Brush Catheter in Thrombosed Polytetrafluoroethylene Dialysis Grafts: Preclinical Animal Study

1998 ◽  
Vol 9 (5) ◽  
pp. 793-798 ◽  
Author(s):  
Flavio Castañeda ◽  
Patrick L. Wyffels ◽  
Jitendra C. Patel ◽  
James L. Swischuk ◽  
Ruizong Li ◽  
...  
Keyword(s):  
Animal Study ◽  
Preclinical Animal Study

In vitro animal study of the spinal cord evoked potentials

1994 ◽  
pp. 407-411
Author(s):  
T. Iwahara ◽  
Y. Atsuta ◽  
M. Imai ◽  
Q. Zhao ◽  
Y. Harada ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Evoked Potentials ◽  
Animal Study ◽  
Spinal Cord Evoked Potentials

scholarly journals Influence of Mineral Oil Lubricant of surgical handpiece on dental Implant osseointegration: In vitro and animal study

2020 ◽  
Vol 31 (S20) ◽  
pp. 78-78
Author(s):  
Heon‐Young Kim ◽  
Min‐Kyoung Kim ◽  
Judong Song ◽  
Sun‐Jong Kim ◽  
Jin‐Woo Kim
Keyword(s):  
Dental Implant ◽  
Animal Study ◽  
Mineral Oil

scholarly journals Effect of the CCL5-Releasing Fibrin Gel for Intervertebral Disc Regeneration

Cartilage ◽  
2018 ◽  
Vol 11 (2) ◽  
pp. 169-180 ◽  
Author(s):  
Zhiyu Zhou ◽  
Stephan Zeiter ◽  
Tanja Schmid ◽  
Daisuke Sakai ◽  
James C. Iatridis ◽  
...  
Keyword(s):  
Animal Study ◽  
Culture Media ◽  
Histopathological Examination ◽  
In Vitro Release ◽  
Dependent Manner ◽  
Fibrin Gel ◽  
Defect Sites ◽  
Intervertebral Disc Regeneration ◽  
Chemotactic Effect

Objective To explore if chemokine (C-C motif) ligand 5 (CCL5) delivery could recruit annulus fibrosus (AF) cells to the injury sites and facilitate the repair of ruptured AF. Design The effects of CCL5 on bovine AF cells in vitro were tested by transwell assay and quantitative real-time polymerase chain reaction. Fibrin gel containing CCL5 was used to treat annulotomized bovine caudal discs cultured under dynamic loading conditions. After 14 days of loading, the samples were collected for histological examination. A pilot animal study was performed using sheep cervical discs to investigate the effect of fibrin gel encapsulated with CCL5 for the treatment of ruptured AF. After 14 weeks, the animals were sacrificed, and the discs were scanned with magnetic resonance imaging before histopathological examination. Results CCL5 showed a chemotactic effect on AF cells in a dose-dependent manner. AF cells cultured with CCL5 in vitro did not show any change of the gene expression of CCL5 receptors, catabolic and proinflammatory markers. In vitro release study showed that CCL5 exhibited sustained release from the fibrin gel into the culture media; however, in the organ culture study CCL5 did not stimulate homing of AF cells toward the defect sites. The pilot animal study did not show any repair effect of CCL5. Conclusions CCL5 has a chemotactic effect on AF cells in vitro, but no ex vivo or in vivo regenerative effect when delivered within fibrin gel. Further study with a stronger chemotactic agent and/or an alternate biomaterial that is more conductive of cell migration is warranted.

A preclinical animal study of a novel, simple, and secure duct and vessel occluder for laparoscopic surgery

2018 ◽  
Vol 32 (7) ◽  
pp. 3311-3320
Author(s):  
Amir Szold ◽  
Arnold Miller ◽  
Nir Lilach ◽  
Ana-Maria Botero-Anug ◽  
Raanan Miller ◽  
...  
Keyword(s):  
Laparoscopic Surgery ◽  
Animal Study ◽  
Preclinical Animal Study

In vitro muscle contracture investigations on the malignant hyperthermia like episodes in myotonia congenita

2013 ◽  
Vol 57 (8) ◽  
pp. 1017-1023 ◽  
Author(s):  
K. HOPPE ◽  
F. LEHMANN-HORN ◽  
S. CHAIKLIENG ◽  
K. JURKAT-ROTT ◽  
O. ADOLPH ◽  
...  
Keyword(s):  
Malignant Hyperthermia ◽  
Myotonia Congenita ◽  
Muscle Contracture

In Vitro and Animal Study of Novel Nano-Hydroxyapatite/Poly(ɛ-Caprolactone) Composite Scaffolds Fabricated by Layer Manufacturing Process

2009 ◽  
Vol 15 (5) ◽  
pp. 977-989 ◽  
Author(s):  
Su-Jin Heo ◽  
Seung-Eon Kim ◽  
Jie Wei ◽  
Dong Hwa Kim ◽  
Young-Taek Hyun ◽  
...  
Keyword(s):  
Animal Study ◽  
Manufacturing Process ◽  
Composite Scaffolds ◽  
Layer Manufacturing

Local Delivery System of Immune Modulating Drug for Unresectable Adenocarcinoma: In Vitro Experimental Study and In Vivo Animal Study

2006 ◽  
Vol 29 (5) ◽  
pp. 832-837 ◽  
Author(s):  
Don Haeng Lee ◽  
Sung-Gwon Kang ◽  
Seok Jeong ◽  
Chang Jin Yoon ◽  
Jung-Ah Choi ◽  
...  
Keyword(s):  
Experimental Study ◽  
Animal Study ◽  
Delivery System ◽  
Local Delivery
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