scholarly journals CrossTalk opposing view: mucosal acidification does not drive early progressive lung disease in cystic fibrosis

2018 ◽  
Vol 596 (16) ◽  
pp. 3439-3441 ◽  
Author(s):  
Stephen M. Stick ◽  
André Schultz
Keyword(s):  
Cystic Fibrosis ◽  
Lung Disease ◽  
Opposing View ◽  
Mucosal Acidification

scholarly journals CrossTalk proposal: mucosal acidification drives early progressive lung disease in cystic fibrosis

2018 ◽  
Vol 596 (16) ◽  
pp. 3433-3437 ◽  
Author(s):  
Miriam F. Figueira ◽  
Megan J. Webster ◽  
Robert Tarran
Keyword(s):  
Cystic Fibrosis ◽  
Lung Disease ◽  
Mucosal Acidification

Regional differences in infection and structural lung disease in infants and young children with cystic fibrosis

2020 ◽  
Vol 19 (6) ◽  
pp. 917-922 ◽  
Author(s):  
Rosemary Carzino ◽  
Katherine B. Frayman ◽  
Louise King ◽  
Suzanna Vidmar ◽  
Sarath Ranganathan
Keyword(s):  
Cystic Fibrosis ◽  
Young Children ◽  
Lung Disease ◽  
Regional Differences ◽  
Infants And Young Children

scholarly journals DNA Methylation at ATP11A cg11702988 Is a Biomarker of Lung Disease Severity in Cystic Fibrosis: A Longitudinal Study

Genes ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 441
Author(s):  
Fanny Pineau ◽  
Davide Caimmi ◽  
Sylvie Taviaux ◽  
Maurane Reveil ◽  
Laura Brosseau ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Dna Methylation ◽  
Clinical Trials ◽  
Lung Disease ◽  
Disease Severity ◽  
Genome Wide ◽  
A Genome ◽  
Lung Disease Severity ◽  
Epigenetic Biomarker

Cystic fibrosis (CF) is a chronic genetic disease that mainly affects the respiratory and gastrointestinal systems. No curative treatments are available, but the follow-up in specialized centers has greatly improved the patient life expectancy. Robust biomarkers are required to monitor the disease, guide treatments, stratify patients, and provide outcome measures in clinical trials. In the present study, we outline a strategy to select putative DNA methylation biomarkers of lung disease severity in cystic fibrosis patients. In the discovery step, we selected seven potential biomarkers using a genome-wide DNA methylation dataset that we generated in nasal epithelial samples from the MethylCF cohort. In the replication step, we assessed the same biomarkers using sputum cell samples from the MethylBiomark cohort. Of interest, DNA methylation at the cg11702988 site (ATP11A gene) positively correlated with lung function and BMI, and negatively correlated with lung disease severity, P. aeruginosa chronic infection, and the number of exacerbations. These results were replicated in prospective sputum samples collected at four time points within an 18-month period and longitudinally. To conclude, (i) we identified a DNA methylation biomarker that correlates with CF severity, (ii) we provided a method to easily assess this biomarker, and (iii) we carried out the first longitudinal analysis of DNA methylation in CF patients. This new epigenetic biomarker could be used to stratify CF patients in clinical trials.

scholarly journals Risk Factors for the Progression of Cystic Fibrosis Lung Disease throughout Childhood

2014 ◽  
Vol 11 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Don B. Sanders ◽  
Zhanhai Li ◽  
Anita Laxova ◽  
Michael J. Rock ◽  
Hara Levy ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cystic Fibrosis ◽  
Lung Disease ◽  
Cystic Fibrosis Lung ◽  
Cystic Fibrosis Lung Disease
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