scholarly journals Collateral impact: a dual role for climbing fibre collaterals to the cerebellar nuclei?

2017 ◽  
Vol 595 (21) ◽  
pp. 6589-6590
Author(s):  
Jasmine Pickford ◽  
Richard Apps
Keyword(s):  
Cerebellar Nuclei ◽  
Dual Role ◽  
Climbing Fibre

scholarly journals The Mesodiencephalic Junction as a Central Hub for Cerebro-Cerebellar Communication

2021 ◽  
Author(s):  
Xiaolu Wang ◽  
Manuele Novello ◽  
Zhenyu Gao ◽  
Tom J.H. Ruigrok ◽  
Chris I. De Zeeuw
Keyword(s):  
Cerebral Cortex ◽  
Inferior Olive ◽  
Cerebellar Nuclei ◽  
Mossy Fibre ◽  
Climbing Fibre ◽  
Climbing Fibres ◽  
The Impact ◽  
Accessory Olive

AbstractMost studies investigating the impact of cerebral cortex (CC) onto the cerebellum highlight the role of the pontine mossy fibre system. However, cerebro-cerebellar communication may also be mediated by the olivary climbing fibres via a hub in the mesodiencephalic junction (MDJ). Here, we show that rostromedial and caudal parts of mouse CC predominantly project to the principal olive via the rostroventral MDJ and that more rostrolateral CC regions prominently project to the rostral medial accessory olive via the caudodorsal MDJ. Moreover, transneuronal tracing results show that the cerebellar nuclei innervate the olivary-projecting neurons in the MDJ that receive input from CC, and that they adhere to the same topographical relations. By unravelling these topographic and dense, mono- and disynaptic projections from the CC through the MDJ and inferior olive to the cerebellum, this work establishes that cerebro-cerebellar communication can be mediated by both the mossy fibre and climbing fibre system.

Dual role of B7 costimulation in obesity-related non-alcoholic steatohepatitis (NASH) and metabolic dysregulation

2014 ◽  
Vol 122 (03) ◽  
Author(s):  
A Chatzigeorgiou ◽  
R Garcia-Martin ◽  
KJ Chung ◽  
I Alexaki ◽  
A Klotzsche-von Ameln ◽  
...  
Keyword(s):  
Dual Role ◽  
Alcoholic Steatohepatitis ◽  
Metabolic Dysregulation

A dual role of the N-terminal FQQI motif in GLUT4 trafficking

2008 ◽  
Vol 3 (S 1) ◽  
Author(s):  
U Bernhardt ◽  
HG Joost ◽  
H Al-Hasani
Keyword(s):  
Dual Role
Sign in / Sign up

Export Citation Format

Share Document