scholarly journals Feto- and utero-placental vascular adaptations to chronic maternal hypoxia in the mouse

2017 ◽  
Vol 596 (15) ◽  
pp. 3285-3297 ◽  
Author(s):  
Lindsay S. Cahill ◽  
Monique Y. Rennie ◽  
Johnathan Hoggarth ◽  
Lisa X. Yu ◽  
Anum Rahman ◽  
...  
Keyword(s):  
Maternal Hypoxia

Vertebral malformation in the mouse foetus caused by X-radiation of the mother during pregnancy

Development ◽  
1964 ◽  
Vol 12 (4) ◽  
pp. 841-850
Author(s):  
Ujihiro Murakami ◽  
Yoshiro Kameyama
Keyword(s):  
Early Pregnancy ◽  
Vertebral Column ◽  
Strain Differences ◽  
In Utero ◽  
Oxygen Deprivation ◽  
Experimental Animals ◽  
Vertebral Malformation ◽  
Pregnant Mice ◽  
Maternal Hypoxia ◽  
In Pregnancy

Maternal hypoxia in early pregnancy can result in malformations of the vertebrae of mouse foetuses, and there is a tendency for more posterior vertebrae to be affected the later in pregnancy the oxygen deprivation occurs (Murakami & Kameyama, 1963). Ingalls et al. (1957) and Degenhardt (1954, 1959) had earlier obtained similar results. We have also exposed pregnant mice to X-radiation and studied the consequent malformations. The effects on the extremities have already been described (Murakami, Kameyama & Nogami, 1963), and in the present paper we shall describe the effects on the vertebral column. Vertebral malformations in animals irradiated in utero have been described by Job, Leibold & Fitzmaurice (1935), Warkany and Schraffenberger (1947), Russell. (1950, 1954), and Russell & Russell (1954). In order to obtain results comparable with those of our experiments with hypoxia, no less than to detect inter-strain differences, we used mice of the ddN and CF1 strains originally supplied by the Central Laboratories for Experimental Animals, Tokyo (Zikkendobutsu Chuo Kenkyujo).

scholarly journals Maternal hypoxia and caffeine exposure depress fetal cardiovascular function during primary organogenesis

2012 ◽  
Vol 38 (12) ◽  
pp. 1343-1351 ◽  
Author(s):  
Nobuo Momoi ◽  
Joseph P. Tinney ◽  
Bradley B. Keller ◽  
Kimimasa Tobita
Keyword(s):  
Cardiovascular Function ◽  
Maternal Hypoxia ◽  
Caffeine Exposure

scholarly journals The effects of experimental acute decrease of uterine perfusion and maternal hypoxia on the fetus

1973 ◽  
Vol 1 (1) ◽  
pp. 36-52 ◽  
Author(s):  
D. Berg ◽  
J. Schulz ◽  
K. Wernicke ◽  
R. Muschaweck
Keyword(s):  
Uterine Perfusion ◽  
Maternal Hypoxia

Hypoxia during pregnancy in rats leads to early morphological changes of atherosclerosis in adult offspring

2009 ◽  
Vol 296 (5) ◽  
pp. H1321-H1328 ◽  
Author(s):  
Zhenhua Wang ◽  
Ziyang Huang ◽  
Guorong Lu ◽  
Ling Lin ◽  
Markus Ferrari
Keyword(s):  
Morphometric Analysis ◽  
Time Course ◽  
Morphological Changes ◽  
Adult Life ◽  
Inflammatory Cells ◽  
Prenatal Hypoxia ◽  
Control Group ◽  
Adult Offspring ◽  
Sprague Dawley ◽  
Maternal Hypoxia

Exposure to an adverse intrauterine environment increases the risk of cardiovascular disease later in adult life. However, the time course relationship between prenatal hypoxia and the onset of atherosclerosis in offspring remains unknown. The purpose of this study is to evaluate the role of reduced fetal oxygen supply on early development of atherogenesis in the adult offspring and further assess its susceptibility to sex-, hyperlipidemia-, and postnatal hypoxemia-related differences. Based on a 4 × 2 full factorial design consisting of four factors of maternal hypoxia, sex, hyperlipidemia, and postnatal hypoxemia, characteristics of growth were determined, and histopathological observation and morphometric analysis of the thoracic aortas were performed in Sprague-Dawley rat offspring. Intrauterine growth restriction, altered body shape at birth, and accelerated postnatal weight gain occurred in the maternal hypoxia group but did not occur in the control group. In 16-mo-old maternal hypoxia offspring, the thoracic aortas exhibited lesions similar to early events in atherosclerosis that involved impaired endothelial cells, thickening and fibration of intimas, infiltration of inflammatory cells to the subendothelial space, and migration and proliferation of vascular smooth muscle cells to the intima. In contrast, no detectable pathological changes were observed in the offspring without maternal hypoxia exposure. Morphometric analysis further demonstrated that prenatal hypoxia caused a significant thickening of intima ( P < 0.001) with a main effect of 5.5 μm, an approximately twofold increase compared with controls. In addition, there was a positive additive relationship between prenatal hypoxia and hyperlipidemia on the intimal thickness ( P < 0.05). There were no other main effects or interaction among these four factors. In summary, our results indicate that maternal hypoxia during pregnancy leads to early pathological appearances of atherogenesis in adult offspring. This effect was enhanced with hyperlipemia but was unaffected by postnatal hypoxia or sex.

Chronic Maternal Hypoxia

1988 ◽  
Vol 10 (3) ◽  
pp. 180-189 ◽  
Author(s):  
J.L. Gingras ◽  
W.A. Long
Keyword(s):  
Maternal Hypoxia

Effects of Maternal Hypoxia on Fetal Pulmonary Circulation

1970 ◽  
Vol 5 (4) ◽  
pp. 282-283
Author(s):  
Michael T. Gyepes ◽  
Forrest H. Adams
Keyword(s):  
Pulmonary Circulation ◽  
Maternal Hypoxia

scholarly journals Real-Time Monitoring of Placental Oxygenation during Maternal Hypoxia and Hyperoxygenation Using Photoacoustic Imaging

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0169850 ◽  
Author(s):  
Chloé J. Arthuis ◽  
Anthony Novell ◽  
Florian Raes ◽  
Jean-Michel Escoffre ◽  
Stéphanie Lerondel ◽  
...  
Keyword(s):  
Real Time ◽  
Photoacoustic Imaging ◽  
Real Time Monitoring ◽  
Maternal Hypoxia
Sign in / Sign up

Export Citation Format

Share Document