scholarly journals Rapid recovery and altered neurochemical dependence of locomotor central pattern generation following lumbar neonatal spinal cord injury

2017 ◽  
Vol 596 (2) ◽  
pp. 281-303 ◽  
Author(s):  
Mark Züchner ◽  
Elena Kondratskaya ◽  
Camilla B. Sylte ◽  
Joel C. Glover ◽  
Jean-Luc Boulland
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Pattern Generation ◽  
Rapid Recovery ◽  
Central Pattern Generation ◽  
Cord Injury

An intracortical neuroprosthesis immediately alleviates walking deficits and improves recovery of leg control after spinal cord injury

2021 ◽  
Vol 13 (586) ◽  
pp. eabb4422
Author(s):  
Marco Bonizzato ◽  
Marina Martinez
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Pattern Generation ◽  
Rhythmic Pattern ◽  
Cortical Control ◽  
Motor Mapping ◽  
Cortical Motor ◽  
Locomotor Control ◽  
Cord Injury

Most rehabilitation interventions after spinal cord injury (SCI) only target the sublesional spinal networks, peripheral nerves, and muscles. However, mammalian locomotion is not a mere act of rhythmic pattern generation. Recovery of cortical control is essential for voluntary movement and modulation of gait. We developed an intracortical neuroprosthetic intervention to SCI, with the goal to condition cortical locomotor control. Neurostimulation delivered in phase coherence with ongoing locomotion immediately alleviated primary SCI deficits, such as leg dragging, in rats with incomplete SCI. Cortical neurostimulation achieved high fidelity and markedly proportional online control of leg trajectories in both healthy and SCI rats. Long-term neuroprosthetic training lastingly improved cortical control of locomotion, whereas short training held transient improvements. We performed longitudinal awake cortical motor mapping, unveiling that recovery of cortico-spinal transmission tightly parallels return of locomotor function in rats. These results advocate directly targeting the motor cortex in clinical neuroprosthetic approaches.

1132: Creation of a Somatic-Autonomic Reflex Pathway for Treatment of Neurogenic Bladder in Patients with Spinal Cord Injury: Preliminary Results of First 2 USA Patients

2005 ◽  
Vol 173 (4S) ◽  
pp. 307-308 ◽  
Author(s):  
Christopher E. Kelly ◽  
Chuan-Guo Xiao ◽  
Howard Weiner ◽  
Aleksandar Beric ◽  
Victor W. Nitti ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurogenic Bladder ◽  
Reflex Pathway ◽  
Preliminary Results ◽  
Cord Injury ◽  
Autonomic Reflex
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