scholarly journals The angiotensin II receptor type 1b is the primary sensor of intraluminal pressure in cerebral artery smooth muscle cells

2017 ◽  
Vol 595 (14) ◽  
pp. 4735-4753 ◽  
Author(s):  
Paulo W. Pires ◽  
Eun-A. Ko ◽  
Harry A.T. Pritchard ◽  
Michael Rudokas ◽  
Evan Yamasaki ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Smooth Muscle Cells ◽  
Cerebral Artery ◽  
Muscle Cells ◽  
Receptor Type ◽  
Intraluminal Pressure ◽  
Angiotensin Ii Receptor ◽  
Primary Sensor

scholarly journals Effect of endotoxin on the angiotensin II receptor in cultured vascular smooth muscle cells

1995 ◽  
Vol 116 (5) ◽  
pp. 2524-2530 ◽  
Author(s):  
Michel Burnier ◽  
Gabriel Centeno ◽  
Gérard Waeber ◽  
Catherine Centeno ◽  
Ernst Bürki
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Angiotensin Ii Receptor

Biochemical Effects of Intraliposomal Angiotensins on Isolated Vascular Smooth Muscle Cells

2018 ◽  
Vol 69 (5) ◽  
pp. 1187-1190
Author(s):  
Diana Tatarciuc ◽  
Decebal Vasincu ◽  
Gabriela Stoleriu ◽  
Roxana Irina Iancu ◽  
Marcel Costuleanu
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Angiotensin Ii Receptor ◽  
Angiotensin Peptides ◽  
Angiotensin Iii ◽  
Apoptotic Effects

The intracellular renin-angiotensin effectors (peptides, enzymes, receptors) and their effects are intriguing for a lot of systems. That�s why we aimed the effects of intracellularly-administered angiotensins (angiotensin II, angiotensin III, angiotensin IV, angiotensin fragment 1-7), angiotensinogen, CGP-42112A, apelin, and angiotensin receptors blockers (losartan, PD123319), by the means of liposomes, on apoptosis of cultured isolated rat aortic vascular smooth muscle cells. We evidenced that CGP-42112A (a potent AT2 angiotensin II receptor agonist), administered intracellularly, induced the apoptosis of the cultured isolated vascular smooth muscle cells in a much higher proportion than other agonists and antagonists of angiotensin system: CGP-42112A ] angiotensin II] angiotensin III@ angiotensinogen. Moreover, losartan (an AT1 angiotensin II receptor antagonist), administered intracellularly, induced an important degree of apoptosis of cultured isolated vascular smooth muscle cells. Losartan, administered as concomitant treatment for other angiotensin peptides and CGP-42112A, did not significantly modified the apoptotic effects of these peptides. On the other hand, PD123319 (an AT2 angiotensin II receptor antagonist) was able to significantly reduce the losartan effects when administered as co-treatment for 24 h. The same effects were obtained when LY294002, a PI3K/Akt signaling inhibitor, was administered as a co-treatment. We can conclude an involvement of an AT2 angiotensin II receptor and PI3K/Akt signaling in these apoptotic effects induced by some angiotensin peptides and losartan on cultured isolated rat aortic vascular smooth muscle cells.

scholarly journals N-Acetylcysteine Decreases Angiotensin II Receptor Binding in Vascular Smooth Muscle Cells

2005 ◽  
Vol 16 (8) ◽  
pp. 2346-2353 ◽  
Author(s):  
Michael E. Ullian ◽  
Andrew K. Gelasco ◽  
Wayne R. Fitzgibbon ◽  
C. Nicole Beck ◽  
Thomas A. Morinelli
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Receptor Binding ◽  
Muscle Cells ◽  
Angiotensin Ii Receptor
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