scholarly journals Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study

2016 ◽  
Vol 595 (2) ◽  
pp. 541-555 ◽  
Author(s):  
Eef Boets ◽  
Sara V. Gomand ◽  
Lise Deroover ◽  
Tom Preston ◽  
Karen Vermeulen ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Stable Isotope ◽  
Healthy Subjects ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Systemic Availability ◽  
Isotope Study ◽  
Stable Isotope Study ◽  
Chain Fatty Acids

Su2123 Incorporation of Colonic Derived Short Chain Fatty Acids in Cholesterol: An In Vivo Stable Isotope Study in Humans

2013 ◽  
Vol 144 (5) ◽  
pp. S-564
Author(s):  
Eef Boets ◽  
Els Houben ◽  
Karen Windey ◽  
Vicky De Preter ◽  
Sara V. Gomand ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Stable Isotope ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Isotope Study ◽  
Stable Isotope Study ◽  
Chain Fatty Acids

scholarly journals Wheat Bran Does Not Affect Postprandial Plasma Short-Chain Fatty Acids from 13C-inulin Fermentation in Healthy Subjects

Nutrients ◽  
2017 ◽  
Vol 9 (1) ◽  
pp. 83 ◽  
Author(s):  
Lise Deroover ◽  
Joran Verspreet ◽  
Anja Luypaerts ◽  
Greet Vandermeulen ◽  
Christophe Courtin ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Wheat Bran ◽  
Healthy Subjects ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids

Influence of Ampicillin, Clindamycin, and Metronidazole on Faecal Excretion of Short-Chain Fatty Acids in Healthy Subjects

1986 ◽  
Vol 21 (5) ◽  
pp. 621-626 ◽  
Author(s):  
T. Høverstad ◽  
B. Carlstedt-Duke ◽  
E. Lingaas ◽  
T. Midtvedt ◽  
K. E. Norin ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Healthy Subjects ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Faecal Excretion ◽  
Chain Fatty Acids

scholarly journals Stable Isotope Model for Assessing Production of Short Chain Fatty Acids from Colon-Derived Sugar: Application in Pigs

1996 ◽  
Vol 126 (12) ◽  
pp. 3069-3076 ◽  
Author(s):  
C. Lawrence Kien ◽  
Robert D. Murray ◽  
Anton Ailabouni ◽  
Priscilla Powers ◽  
Jon Kepner ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Stable Isotope ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids

scholarly journals Effect of Wheat Bran on Fecal Butyrate-Producing Bacteria and Wheat Bran Combined with Barley on Bacteroides Abundance in Japanese Healthy Adults

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1980 ◽  
Author(s):  
Seiichiro Aoe ◽  
Fumiko Nakamura ◽  
Suguru Fujiwara
Keyword(s):  
Fatty Acids ◽  
Wheat Bran ◽  
Resistant Starch ◽  
Healthy Subjects ◽  
Interactive Effect ◽  
Short Chain Fatty Acids ◽  
Fecal Microbiota ◽  
Short Chain ◽  
Cereal Bars ◽  
Chain Fatty Acids

Wheat bran (WB) is rich in insoluble arabinoxylan, while BARLEYmax (BM) is a barley line that is rich in fructan, resistant starch, and β-glucan. In the present study, we investigated which of these two fiber sources would produce more favorable changes in the fecal variables of healthy subjects. Sixty healthy subjects were randomly divided into four groups (n = 15 per group) and fed twice daily for 4 weeks with baked cereal bars containing neither WB nor BM (WB−BM−), WB without BM (WB+BM−), BM without WB (WB−BM+), or WB and BM (WB+BM+). At baseline and after 4 weeks, the fecal microbiota composition and the concentrations of short-chain fatty acids were measured. A significant interactive effect of WB and BM on the abundance of genus Bacteroides was observed at week 4. The abundance of butyrate-producing bacteria and the fecal concentration of n-butyrate were significantly higher in the WB+ groups than in the WB− groups. In conclusion, WB was associated with elevated fecal concentrations of short-chain fatty acids including butyrate owing to an increase in the abundance of butyrate-producing bacteria. Additionally, the combination of WB and BM was associated with an increase in the abundance of genus Bacteroides. Therefore, both WB alone and WB combined with BM favorably influenced the fecal variables of healthy subjects.

The fermentable fibre inulin increases postprandial serum short-chain fatty acids and reduces free-fatty acids and ghrelin in healthy subjects

2010 ◽  
Vol 35 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Joshua Tarini ◽  
Thomas M.S. Wolever
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Dietary Fibre ◽  
Healthy Subjects ◽  
Gut Hormones ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids

It is thought that diets high in dietary fibre are associated with reduced risk for type 2 diabetes, at least in part because the short-chain fatty acids (SCFAs) produced during the colonic fermentation of fibre beneficially influence circulating concentrations of free-fatty acids (FFAs) and gut hormones involved in the regulation of blood glucose and body mass. However, there is a paucity of data showing this sequence of events in humans. Thus, our objective was to determine the effect of the fermentable fibre inulin on postprandial glucose, insulin, SCFA, FFA, and gut hormone responses in healthy subjects. Overnight fasted healthy subjects (n = 12) were studied for 6 h after consuming 400 mL drinks, containing 80 g high-fructose corn syrup (80HFCS), 56 g HFCS (56HFCS), or 56 g HFCS plus 24 g inulin (Inulin), using a randomized, single-blind, crossover design. A standard lunch was served 4 h after the test drink. Glucose and insulin responses after Inulin did not differ significantly from those after 80HFCS or 56HFCS. Serum acetate, propionate, and butyrate were significantly higher after Inulin than after HFCS drinks from 4–6 h. FFAs fell at a similar rate after all 3 test drinks, but were lower after Inulin than after 56HFCS at 4 h (0.40 ± 0.06 vs. 0.51 ± 0.06 mmol·L–1; p < 0.05). Compared with 56HFCS, Inulin significantly increased plasma glucagon-like peptide-1 concentrations at 30 min, and reduced ghrelin at 4.5 h and 6 h. The results are consistent with the hypothesis that dietary fibre increases the production of colonic SCFAs, which may reduce type 2 diabetes risk by reducing postprandial FFAs and favorably affecting gut hormones, which regulate food intake.

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