scholarly journals The acquisition of mechano‐electrical transducer current adaptation in auditory hair cells requires myosin VI

2016 ◽  
Vol 594 (13) ◽  
pp. 3667-3681 ◽  
Author(s):  
Walter Marcotti ◽  
Laura F. Corns ◽  
Richard J. Goodyear ◽  
Agnieszka K. Rzadzinska ◽  
Karen B. Avraham ◽  
...  
Keyword(s):  
Hair Cells ◽  
Myosin Vi ◽  
Auditory Hair Cells ◽  
Electrical Transducer

scholarly journals TMC1 is an essential component of a leak channel that modulates tonotopy and excitability of auditory hair cells in mice

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Shuang Liu ◽  
Shufeng Wang ◽  
Linzhi Zou ◽  
Jie Li ◽  
Chenmeng Song ◽  
...  
Keyword(s):  
Hair Cells ◽  
Dependent Manner ◽  
Biological Processes ◽  
Action Potential Firing ◽  
Cochlear Hair Cells ◽  
Auditory Hair Cells ◽  
Leak Channel ◽  
Transmembrane Channel ◽  
Electrical Transducer ◽  
Potential Firing

Hearing sensation relies on the mechano-electrical transducer (MET) channel of cochlear hair cells, in which transmembrane channel-like 1 (TMC1) and transmembrane channel-like 2 (TMC2) have been proposed to be the pore-forming subunits in mammals. TMCs were also found to regulate biological processes other than MET in invertebrates, ranging from sensations to motor function. However, whether TMCs have a non-MET role remains elusive in mammals. Here, we report that in mouse hair cells, TMC1, but not TMC2, provides a background leak conductance, with properties distinct from those of the MET channels. By cysteine substitutions in TMC1, we characterized four amino acids that are required for the leak conductance. The leak conductance is graded in a frequency-dependent manner along the length of the cochlea and is indispensable for action potential firing. Taken together, our results show that TMC1 confers a background leak conductance in cochlear hair cells, which may be critical for the acquisition of sound-frequency and -intensity.

scholarly journals TMC1 Confers a Leak Conductance to Modulate Excitability of Auditory Hair Cells in Mammals

2019 ◽  
Author(s):  
Shuang Liu ◽  
Shufeng Wang ◽  
Linzhi Zou ◽  
Jie Li ◽  
Chenmeng Song ◽  
...  
Keyword(s):  
Hair Cells ◽  
Biological Processes ◽  
Membrane Excitability ◽  
Action Potential Firing ◽  
Cochlear Hair Cells ◽  
Auditory Hair Cells ◽  
Transmembrane Channel ◽  
Electrical Transducer ◽  
Potential Firing ◽  
Open Question

ABSTRACTHearing sensation relies on the mechano-electrical transducer (MET) channel of cochlear hair cells, in which Transmembrane channel-like 1 (TMC1) and TMC2 have been proposed to be the pore-forming subunits. Meanwhile it has been reported that TMCs regulate other biological processes in a variety of lower organisms ranging from sensations to motor functions. However, it is still an open question whether TMCs play roles other than their function in MET in mammals. In this study, we report that in mouse hair cells TMC1, but not TMC2, provides a background leak conductance, with properties distinct from those of the MET channels. By cysteine substitution, 4 amino acids of TMC1 are characterized critical for the leak conductance. The leak conductance is essential for action potential firing and tonotopic along the cochlear coil. Taken together, our results suggest that TMC1 confers a background leak conductance that modulates membrane excitability in cochlear hair cells.

Hydrogen protects auditory hair cells from free radicals

Neuroreport ◽  
2009 ◽  
Vol 20 (7) ◽  
pp. 689-694 ◽  
Author(s):  
Yayoi S. Kikkawa ◽  
Takayuki Nakagawa ◽  
Rie T. Horie ◽  
Juichi Ito
Keyword(s):  
Free Radicals ◽  
Hair Cells ◽  
Auditory Hair Cells

Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells

2021 ◽  
Author(s):  
Jing Liu ◽  
Shengxiong Wang ◽  
Yan Lu ◽  
Haoyu Wang ◽  
Fangfang Wang ◽  
...  
Keyword(s):  
Hair Cells ◽  
Auditory Hair Cells
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