scholarly journals Is plasticity within the retrotrapezoid nucleus responsible for the recovery of the PCO2 set-point after carotid body denervation in rats?

2016 ◽  
Vol 594 (12) ◽  
pp. 3371-3390 ◽  
Author(s):  
Tyler M. Basting ◽  
Chikara Abe ◽  
Kenneth E. Viar ◽  
Ruth L. Stornetta ◽  
Patrice G. Guyenet
Keyword(s):  
Carotid Body ◽  
Set Point ◽  
Retrotrapezoid Nucleus ◽  
Carotid Body Denervation

Plasticity of cardiovascular chemoreflexes after prolonged unilateral carotid body denervation: implications for its therapeutic use

2020 ◽  
Vol 318 (5) ◽  
pp. H1325-H1336
Author(s):  
Jaime Eugenín ◽  
Carolina Larraín ◽  
Patricio Zapata
Keyword(s):  
Carotid Body ◽  
Therapeutic Use ◽  
Therapeutic Effectiveness ◽  
Sympathetic Outflow ◽  
Sympathetic Hyperactivity ◽  
Functional Changes ◽  
Human Disorders ◽  
Carotid Body Denervation

Unilateral carotid body denervation has been proposed as treatment for sympathetic hyperactivity-related human disorders. Its therapeutic effectiveness for maintaining a persistent decrease in the sympathetic outflow activity will depend on the absence of compensatory chemoreflex plasticity in the remnant carotid and aortic afferents. Here, we suggest that the integrity of central afferents after carotid body denervation is essential to prevent the emergence of plastic functional changes on the contralateral “intact” carotid nerve.

scholarly journals Carotid Body Denervation Markedly Improves Survival in Rats With Hypertensive Heart Failure

2017 ◽  
Vol 30 (8) ◽  
pp. 791-798 ◽  
Author(s):  
Kana Fujii ◽  
Keita Saku ◽  
Takuya Kishi ◽  
Yasuhiro Oga ◽  
Takeshi Tohyama ◽  
...  
Keyword(s):  
Heart Failure ◽  
Carotid Body ◽  
Carotid Body Denervation

Effect of carotid body denervation on arousal response to hypoxia in sleeping dogs

1981 ◽  
Vol 51 (1) ◽  
pp. 40-45 ◽  
Author(s):  
G. Bowes ◽  
E. R. Townsend ◽  
L. F. Kozar ◽  
S. M. Bromley ◽  
E. A. Phillipson
Keyword(s):  
Carotid Body ◽  
Rem Sleep ◽  
Slow Wave Sleep ◽  
Sleep Stage ◽  
Critical Role ◽  
Ventilatory Responses ◽  
Progressive Hypoxia ◽  
Arousal Response ◽  
Arterial O2 Saturation ◽  
Carotid Body Denervation

We studied the arousal and ventilatory responses to hypoxia during sleep in three trained dogs, before and 1–4 wk after carotid body denervation (CBD). During the studies the dogs breathed through a cuffed endotracheal tube inserted via a chronic tracheostomy. Eucapnic progressive hypoxia was induced by a rebreathing technique, and arterial O2 saturation (Sao2) was measured with an ear oximeter. Sleep stage was determined by electroencephalographic and behavioral criteria. Following CBD, all dogs exhibited hypoventilation under resting conditions; hypoxic ventilatory responses during wakefulness, slow-wave sleep (SWS), and rapid-eye-movement (REM) sleep were less than 10% of control. Prior to CBD, hypoxic arousal occurred at Sao2 of 83.2 +/- 4.6% (mean +/- Se) during SWS and 70.6 +/-2.2% in REM sleep. Following CBD, arousal failed to occur during progressive desaturation to 60% in SWS and 50% in REM sleep, at which levels hypoxia was arbitrarily terminated. In a few studies following CBD where rebreathing was allowed to continue, the dogs occasionally failed to arouse at all and require active resuscitation. The results indicate a critical role for the carotid chemoreceptors in mediating the arousal response to hypoxia.

scholarly journals Carotid body denervation does not affect CO2 sensitivity in multiple rat strains

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Gary Charles Mouradian ◽  
Justin Miller ◽  
Clarissa Muere ◽  
Hubert V. Forster ◽  
Matthew R. Hodges
Keyword(s):  
Carotid Body ◽  
Rat Strains ◽  
Co2 Sensitivity ◽  
Carotid Body Denervation

scholarly journals Activation of Retrotrapezoid Nucleus (RTN) Maintains Normal Breathing in Hyperoxia Despite the Loss of Carotid Body (CB) Input

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Tyler Basting ◽  
Peter Burke ◽  
Daniel Stornetta ◽  
Ruth Stornetta ◽  
Patrice Guyenet
Keyword(s):  
Carotid Body ◽  
Retrotrapezoid Nucleus ◽  
Normal Breathing
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