scholarly journals The effect of lung deformation on the spatial distribution of pulmonary blood flow

2016 ◽  
Vol 594 (21) ◽  
pp. 6333-6347 ◽  
Author(s):  
Tatsuya J. Arai ◽  
Rebecca J. Theilmann ◽  
Rui Carlos Sá ◽  
Michael T. Villongco ◽  
Susan R. Hopkins
Keyword(s):  
Blood Flow ◽  
Spatial Distribution ◽  
Pulmonary Blood Flow ◽  
Lung Deformation

Spatial distribution of venous gas emboli in the lungs

1999 ◽  
Vol 87 (5) ◽  
pp. 1937-1947 ◽  
Author(s):  
Jennifer E. Souders ◽  
Jeffrey B. Doshier ◽  
Nayak L. Polissar ◽  
Michael P. Hlastala
Keyword(s):  
Blood Flow ◽  
Spatial Distribution ◽  
Pulmonary Blood Flow ◽  
Flow Dynamics ◽  
Pulmonary Vasculature ◽  
Pulmonary Emboli ◽  
Fluorescent Microspheres ◽  
Spatial Coordinates ◽  
Anesthetized Dogs ◽  
Baseline Flow

The distribution of gaseous pulmonary emboli is presumed to be determined by their buoyancy. We hypothesized that regional pulmonary blood flow may also influence their distribution. Therefore, pulmonary blood flow was measured in supine, anesthetized dogs with use of 15-μm fluorescent microspheres at baseline and during N2 embolism. The animals were killed, and the lungs were excised, air-dried, and diced into ∼2-cm3 pieces with weights and spatial coordinates recorded. Embolism was defined as a >10% flow decrease relative to baseline. Vertically, the incidence of embolism increased substantially by 6 ± 1% per additional centimeter in height compared with baseline ( P = 0.0003). Embolism also increased radially by 3 ± 1%/cm from the hilum ( P = 0.002). There was a weaker but statistically significant increase in embolism to pieces with greater baseline flow, 9 ± 2% for every 1.0 increase in relative baseline flow ( P = 0.008). We conclude that the distribution of gaseous emboli is influenced by buoyancy and flow dynamics within the pulmonary vasculature.

Spatial distribution of pulmonary blood flow in dogs in increased force environments

1978 ◽  
Vol 44 (3) ◽  
pp. 384-396 ◽  
Author(s):  
J. F. Greenleaf ◽  
E. L. Ritman ◽  
P. A. Chevalier ◽  
D. J. Sass ◽  
E. H. Wood
Keyword(s):  
Blood Flow ◽  
Spatial Distribution ◽  
Cross Sections ◽  
Pulmonary Blood Flow ◽  
Dependent Lung ◽  
Alveolar Volume ◽  
Extravascular Fluid ◽  
Flow Through ◽  
Left And Right ◽  
Isotope Distributions

Spatial distribution of pulmonary blood flow (SDPBF) during 2- to 3-min exposures to 6–8 Gy acceleration was studied, using radioactive microspheres in dogs, and compared to previously reported 1 Gy control distributions. Isotope distributions were measured by scintiscanning individual 1-cm-thick cross sections of excised, fixed lungs. Results indicate: 1) the fraction of cardiac output traversing left and right lungs did not change systematically with the duration and magnitude of acceleration; but 2) the fraction is strongly affected by the occurrence or absence of fast deep breaths, which cause an increase or decrease, respectively, in blood flow through the dependent lung; and 3) Gy acceleration caused a significant increase in relative pulmonary vascular resistance (PVR) in nondependent and dependent regions of the lung concurrent with a decrease in PVR in the midsagittal region of the thorax. Result 3 may be mediated primarily by changes in regional alveolar volume and geometry in the nondependent hemithorax conbined with hydrostatic effects of extravascular fluid and active hypoxic response in the dependent region and is superimposed on, and may override, hydrostatic effects of perfusion pressures on SDPBF during acceleration.

scholarly journals Spatial pattern of pulmonary blood flow distribution is stable over days

1997 ◽  
Vol 82 (3) ◽  
pp. 902-907 ◽  
Author(s):  
Robb W. Glenny ◽  
Steven McKinney ◽  
H. Thomas Robertson
Keyword(s):  
Blood Flow ◽  
Spatial Distribution ◽  
Coefficient Of Variation ◽  
Pulmonary Blood Flow ◽  
Flow Distribution ◽  
Regional Perfusion ◽  
Spatial And Temporal Variation ◽  
Pulmonary Perfusion ◽  
Blood Flow Distribution ◽  
Time Periods

Glenny, Robb W., Steven McKinney, and H. Thomas Robertson.Spatial pattern of pulmonary blood flow distribution is stable over days. J. Appl. Physiol. 82(3): 902–907, 1997.—Despite the heterogeneous distribution of regional pulmonary perfusion over space, local perfusion remains stable over short time periods (20–100 min). The purpose of this study was to determine whether the spatial distribution of pulmonary perfusion remains stable over longer time periods (1–5 days). Regional blood flow was measured each day for 5 days in five awake standing dogs. Fluorescent microspheres of different colors were injected into a limb vein over 30 s on each day. After the last microsphere injection, the dogs were killed, and lungs were flushed free of blood, excised, dried at total lung capacity, and diced into ∼2-cm3 pieces ( n = 1,296–1,487 per dog). Relative blood flow to each piece on each day was determined by extracting the fluorescent dyes and determining the concentrations of each color. We established that blood flow is spatially heterogeneous with a coefficient of variation of 29.5 ± 2%. Blood flow to each piece is highly correlated with flow to the same piece on all days ( r = 0.930 ± 0.006). The temporal heterogeneity of regional perfusion as measured by the coefficient of variation is 6.9 ± 0.7% over the 5 days and is nonrandom. The magnitude of spatial and temporal variation is significantly less than previously reported in a study in which anesthetized and mechanically ventilated dogs were used. We conclude that spatial distribution of pulmonary blood flow remains stable over days and we speculate that in the normal awake dog regional perfusion is determined primarily by a fixed structure such as the geometry of the pulmonary vascular tree rather than by local vasoactive regulators. Anesthesia and/or mechanical ventilation may increase the temporal variability in regional perfusion.

Noninvasive Investigation of Pulmonary Blood Flow in Children with Pulmonary Hypertension Using the TRV/RVOT VTI Ratio

2017 ◽  
Vol 65 (S 02) ◽  
pp. S111-S142
Author(s):  
M. Koestenberger ◽  
D. Baumgartner ◽  
G. Hansmann ◽  
S. Schweintzger ◽  
G. Grangl ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pulmonary Hypertension ◽  
Pulmonary Blood Flow

Additional pulmonary blood flow in Glenn anastomosis has no adverse effect on outcome of later TCPC

2004 ◽  
Vol 52 (S 1) ◽  
Author(s):  
PA Berdat ◽  
A Serraf ◽  
E Belli ◽  
F Lacour-Gayet ◽  
C Planch� ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Blood Flow ◽  
Pulmonary Blood Flow
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