scholarly journals Direct effect of chronic hypoxia in suppressing large conductance Ca2+-activated K+channel activity in ovine uterine arteries via increasing oxidative stress

2015 ◽  
Vol 594 (2) ◽  
pp. 343-356 ◽  
Author(s):  
Xiang-Qun Hu ◽  
Xiaohui Huang ◽  
Daliao Xiao ◽  
Lubo Zhang
Keyword(s):  
Oxidative Stress ◽  
Direct Effect ◽  
Chronic Hypoxia ◽  
K Channel ◽  
Channel Activity ◽  
Uterine Arteries

scholarly journals Chronic Hypoxia Suppresses Pregnancy-Induced Upregulation of Large-Conductance Ca 2+ -Activated K + Channel Activity in Uterine Arteries

Hypertension ◽  
2012 ◽  
Vol 60 (1) ◽  
pp. 214-222 ◽  
Author(s):  
Xiang-Qun Hu ◽  
Daliao Xiao ◽  
Ronghui Zhu ◽  
Xiaohui Huang ◽  
Shumei Yang ◽  
...  
Keyword(s):  
Chronic Hypoxia ◽  
K Channel ◽  
Channel Activity ◽  
Uterine Arteries

scholarly journals Hypoxia Represses ER-α Expression and Inhibits Estrogen-Induced Regulation of Ca 2+ -Activated K + Channel Activity and Myogenic Tone in Ovine Uterine Arteries

Hypertension ◽  
2015 ◽  
Vol 66 (1) ◽  
pp. 44-51 ◽  
Author(s):  
Man Chen ◽  
Daliao Xiao ◽  
Xiang-Qun Hu ◽  
Chiranjib Dasgupta ◽  
Shumei Yang ◽  
...  
Keyword(s):  
K Channel ◽  
Myogenic Tone ◽  
Channel Activity ◽  
Uterine Arteries

scholarly journals Chronic hypoxia upregulates DNA methyltransferase and represses large conductance Ca2+-activated K+ channel function in ovine uterine arteries†

2017 ◽  
Vol 96 (2) ◽  
pp. 424-434 ◽  
Author(s):  
Xiang-Qun Hu ◽  
Man Chen ◽  
Chiranjib Dasgupta ◽  
Daliao Xiao ◽  
Xiaohui Huang ◽  
...  
Keyword(s):  
Dna Methyltransferase ◽  
Chronic Hypoxia ◽  
K Channel ◽  
Uterine Arteries ◽  
Channel Function

scholarly journals Pregnancy Upregulates Large-Conductance Ca 2+ -Activated K + Channel Activity and Attenuates Myogenic Tone in Uterine Arteries

Hypertension ◽  
2011 ◽  
Vol 58 (6) ◽  
pp. 1132-1139 ◽  
Author(s):  
Xiang-Qun Hu ◽  
Daliao Xiao ◽  
Ronghui Zhu ◽  
Xiaohui Huang ◽  
Shumei Yang ◽  
...  
Keyword(s):  
K Channel ◽  
Myogenic Tone ◽  
Channel Activity ◽  
Uterine Arteries

scholarly journals The trafficking protein SYP121 of Arabidopsis connects programmed stomatal closure and K + channel activity with vegetative growth

2011 ◽  
Vol 69 (2) ◽  
pp. 241-251 ◽  
Author(s):  
Cornelia Eisenach ◽  
Zhong‐Hua Chen ◽  
Christopher Grefen ◽  
Michael R. Blatt
Keyword(s):  
Vegetative Growth ◽  
Stomatal Closure ◽  
K Channel ◽  
Channel Activity

scholarly journals Opposing effects of oxidants and antioxidants on K+ channel activity and tone in rat vascular tissue

1995 ◽  
Vol 80 (5) ◽  
pp. 825-834 ◽  
Author(s):  
HL Reeve ◽  
EK Weir ◽  
DP Nelson ◽  
DA Peterson ◽  
SL Archer
Keyword(s):  
Vascular Tissue ◽  
K Channel ◽  
Channel Activity ◽  
Opposing Effects

scholarly journals Large-conductance voltage- and Ca2+-activated K+ channel regulation by protein kinase C in guinea pig urinary bladder smooth muscle

2014 ◽  
Vol 306 (5) ◽  
pp. C460-C470 ◽  
Author(s):  
Kiril L. Hristov ◽  
Amy C. Smith ◽  
Shankar P. Parajuli ◽  
John Malysz ◽  
Georgi V. Petkov
Keyword(s):  
Smooth Muscle ◽  
Membrane Potential ◽  
Guinea Pig ◽  
Bk Channels ◽  
Bk Channel ◽  
K Channel ◽  
Channel Activity ◽  
Open Probability ◽  
Channel Regulation ◽  
Pkc Activation

Large-conductance voltage- and Ca2+-activated K+ (BK) channels are critical regulators of detrusor smooth muscle (DSM) excitability and contractility. PKC modulates the contraction of DSM and BK channel activity in non-DSM cells; however, the cellular mechanism regulating the PKC-BK channel interaction in DSM remains unknown. We provide a novel mechanistic insight into BK channel regulation by PKC in DSM. We used patch-clamp electrophysiology, live-cell Ca2+ imaging, and functional studies of DSM contractility to elucidate BK channel regulation by PKC at cellular and tissue levels. Voltage-clamp experiments showed that pharmacological activation of PKC with PMA inhibited the spontaneous transient BK currents in native freshly isolated guinea pig DSM cells. Current-clamp recordings revealed that PMA significantly depolarized DSM membrane potential and inhibited the spontaneous transient hyperpolarizations in DSM cells. The PMA inhibitory effects on DSM membrane potential were completely abolished by the selective BK channel inhibitor paxilline. Activation of PKC with PMA did not affect the amplitude of the voltage-step-induced whole cell steady-state BK current or the single BK channel open probability (recorded in cell-attached mode) upon inhibition of all major Ca2+ sources for BK channel activation with thapsigargin, ryanodine, and nifedipine. PKC activation with PMA elevated intracellular Ca2+ levels in DSM cells and increased spontaneous phasic and nerve-evoked contractions of DSM isolated strips. Our results support the concept that PKC activation leads to a reduction of BK channel activity in DSM via a Ca2+-dependent mechanism, thus increasing DSM contractility.

Inhibitory Effects of Methylglyoxal on Light-Induced Stomatal Opening and Inward K+Channel Activity inArabidopsis

2012 ◽  
Vol 76 (3) ◽  
pp. 617-619 ◽  
Author(s):  
Tahsina Sharmin HOQUE ◽  
Eiji OKUMA ◽  
Misugi URAJI ◽  
Takuya FURUICHI ◽  
Takayuki SASAKI ◽  
...  
Keyword(s):  
Stomatal Opening ◽  
K Channel ◽  
Channel Activity ◽  
Inhibitory Effects
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