scholarly journals TRPM7 kinase activity regulates murine mast cell degranulation

2016 ◽  
Vol 594 (11) ◽  
pp. 2957-2970 ◽  
Author(s):  
Susanna Zierler ◽  
Adriana Sumoza-Toledo ◽  
Sayuri Suzuki ◽  
Fionán Ó Dúill ◽  
Lillia V. Ryazanova ◽  
...  
Keyword(s):  
Mast Cell ◽  
Kinase Activity ◽  
Mast Cell Degranulation ◽  
Murine Mast Cell

scholarly journals Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation

2020 ◽  
Vol 204 (12) ◽  
pp. 3077-3085 ◽  
Author(s):  
Kazuki Yoshida ◽  
Masa-aki Ito ◽  
Naoko Sato ◽  
Kosuke Obayashi ◽  
Kimiko Yamamoto ◽  
...  
Keyword(s):  
Mast Cell ◽  
Receptor Activation ◽  
Extracellular Atp ◽  
Mast Cell Degranulation ◽  
P2x4 Receptor ◽  
Murine Mast Cell

Mode of Mast Cell Degranulation

1971 ◽  
Vol 33 (3) ◽  
pp. 223-228
Author(s):  
Shojiro MORIYASU
Keyword(s):  
Mast Cell ◽  
Mast Cell Degranulation

Dexamethasone and CD300a activation display additive inhibitory effect on human and murine mast cell functions

2021 ◽  
Author(s):  
Pratibha Gaur ◽  
Fidan Rahimli Alekberli ◽  
Laila Karra ◽  
David Mankuta ◽  
Micha Ben Zimra ◽  
...  
Keyword(s):  
Mast Cell ◽  
Inhibitory Effect ◽  
Cell Functions ◽  
Murine Mast Cell

scholarly journals Platelet and Erythrocyte Extravasation across Inflamed Corneal Venules Depend on CD18, Neutrophils and Mast Cell Degranulation

2021 ◽  
Vol 22 (14) ◽  
pp. 7360
Author(s):  
Angie De La Cruz ◽  
Aubrey Hargrave ◽  
Sri Magadi ◽  
Justin A. Courson ◽  
Paul T. Landry ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Types ◽  
Mast Cell Degranulation ◽  
Wild Type ◽  
Delayed Wound Healing ◽  
Corneal Epithelial ◽  
Corneal Abrasion ◽  
Low Levels ◽  
Endothelial Pores

Platelet extravasation during inflammation is under-appreciated. In wild-type (WT) mice, a central corneal epithelial abrasion initiates neutrophil (PMN) and platelet extravasation from peripheral limbal venules. The same injury in mice expressing low levels of the β2-integrin, CD18 (CD18hypo mice) shows reduced platelet extravasation with PMN extravasation apparently unaffected. To better define the role of CD18 on platelet extravasation, we focused on two relevant cell types expressing CD18: PMNs and mast cells. Following corneal abrasion in WT mice, we observed not only extravasated PMNs and platelets but also extravasated erythrocytes (RBCs). Ultrastructural observations of engorged limbal venules showed platelets and RBCs passing through endothelial pores. In contrast, injured CD18hypo mice showed significantly less venule engorgement and markedly reduced platelet and RBC extravasation; mast cell degranulation was also reduced compared to WT mice. Corneal abrasion in mast cell-deficient (KitW-sh/W-sh) mice showed less venule engorgement, delayed PMN extravasation, reduced platelet and RBC extravasation and delayed wound healing compared to WT mice. Finally, antibody-induced depletion of circulating PMNs prior to corneal abrasion reduced mast cell degranulation, venule engorgement, and extravasation of PMNs, platelets, and RBCs. In summary, in the injured cornea, platelet and RBC extravasation depends on CD18, PMNs, and mast cell degranulation.

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