scholarly journals Mathematical modelling of local calcium and regulated exocytosis during inhibition and stimulation of glucagon secretion from pancreatic alpha-cells

2015 ◽  
Vol 593 (20) ◽  
pp. 4519-4530 ◽  
Author(s):  
Francesco Montefusco ◽  
Morten Gram Pedersen
Keyword(s):  
Mathematical Modelling ◽  
Glucagon Secretion ◽  
Alpha Cells ◽  
Regulated Exocytosis ◽  
Pancreatic Alpha Cells ◽  
Stimulation Of

scholarly journals GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca2+ channels

2018 ◽  
Vol 6 (17) ◽  
pp. e13852 ◽  
Author(s):  
Reshma Ramracheya ◽  
Caroline Chapman ◽  
Margarita Chibalina ◽  
Haiqiang Dou ◽  
Caroline Miranda ◽  
...  
Keyword(s):  
Glucagon Secretion ◽  
Alpha Cells ◽  
Pancreatic Alpha Cells ◽  
Ca2 Channels

scholarly journals Role of 12-lipoxygenase in glucagon secretion from rat pancreatic alpha cells

1998 ◽  
Vol 76 ◽  
pp. 100
Author(s):  
Hiroo Kawajiri ◽  
Na Qiao ◽  
Da-Ming Zhuang ◽  
Tanihiro Yoshimoto ◽  
Miyuki Yamamoto ◽  
...  
Keyword(s):  
Glucagon Secretion ◽  
Alpha Cells ◽  
Pancreatic Alpha Cells ◽  
12 Lipoxygenase

scholarly journals LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia

2015 ◽  
Vol 4 (4) ◽  
pp. 277-286 ◽  
Author(s):  
Gao Sun ◽  
Gabriela da Silva Xavier ◽  
Tracy Gorman ◽  
Claire Priest ◽  
Antonia Solomou ◽  
...  
Keyword(s):  
Glucagon Secretion ◽  
Alpha Cells ◽  
Pancreatic Alpha Cells

scholarly journals Mathematical Modeling of Human Pancreatic Alpha-Cells: Insight into the Role of SGLT2 in Glucagon Secretion

2016 ◽  
Vol 110 (3) ◽  
pp. 452a
Author(s):  
Morten G. Pedersen ◽  
Ingela Ahlstedt ◽  
Eva-Marie Andersson ◽  
Sven Göpel
Keyword(s):  
Mathematical Modeling ◽  
Glucagon Secretion ◽  
Alpha Cells ◽  
Pancreatic Alpha Cells ◽  
Insight Into

1919-P: Dysfunction of BCAA Catabolism in Pancreatic Alpha Cells Is Associated with Higher Glucagon Secretion in Diabetic Mice

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1919-P
Author(s):  
ERI WADA ◽  
MASAKI KOBAYASHI ◽  
OSAMU KIKUCHI ◽  
DAISUKE KOHNO ◽  
TADAHIRO KITAMURA
Keyword(s):  
Glucagon Secretion ◽  
Alpha Cells ◽  
Diabetic Mice ◽  
Pancreatic Alpha Cells

scholarly journals Expression of insulin receptor on clonal pancreatic alpha cells and its possible role for insulin-stimulated negative regulation of glucagon secretion

Diabetologia ◽  
1995 ◽  
Vol 38 (4) ◽  
pp. 422-429 ◽  
Author(s):  
K. Kisanuki ◽  
H. Kishikawa ◽  
E. Araki ◽  
T. Shirotani ◽  
M. Uehara ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Glucagon Secretion ◽  
Negative Regulation ◽  
Alpha Cells ◽  
Pancreatic Alpha Cells

scholarly journals Glucokinase intrinsically regulates glucose sensing and glucagon secretion in pancreatic alpha cells

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Tilo Moede ◽  
Barbara Leibiger ◽  
Pilar Vaca Sanchez ◽  
Elisabetta Daré ◽  
Martin Köhler ◽  
...  
Keyword(s):  
Glucose Sensor ◽  
Glucagon Secretion ◽  
Glucose Sensing ◽  
Glucagon Release ◽  
Alpha Cells ◽  
Intrinsic Factors ◽  
Pancreatic Alpha Cells ◽  
And Function ◽  
Cell Glucose

AbstractThe secretion of glucagon by pancreatic alpha cells is regulated by a number of external and intrinsic factors. While the electrophysiological processes linking a lowering of glucose concentrations to an increased glucagon release are well characterized, the evidence for the identity and function of the glucose sensor is still incomplete. In the present study we aimed to address two unsolved problems: (1) do individual alpha cells have the intrinsic capability to regulate glucagon secretion by glucose, and (2) is glucokinase the alpha cell glucose sensor in this scenario. Single cell RT-PCR was used to confirm that glucokinase is the main glucose-phosphorylating enzyme expressed in rat pancreatic alpha cells. Modulation of glucokinase activity by pharmacological activators and inhibitors led to a lowering or an increase of the glucose threshold of glucagon release from single alpha cells, measured by TIRF microscopy, respectively. Knockdown of glucokinase expression resulted in a loss of glucose control of glucagon secretion. Taken together this study provides evidence for a crucial role of glucokinase in intrinsic glucose regulation of glucagon release in rat alpha cells.

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