scholarly journals Ca2+current facilitation determines short-term facilitation at inhibitory synapses between cerebellar Purkinje cells

2015 ◽  
Vol 593 (22) ◽  
pp. 4889-4904 ◽  
Author(s):  
Françoise Díaz-Rojas ◽  
Takeshi Sakaba ◽  
Shin-ya Kawaguchi
Keyword(s):  
Purkinje Cells ◽  
Inhibitory Synapses ◽  
Short Term ◽  
Cerebellar Purkinje Cells ◽  
Current Facilitation

Cbln1 downregulates the formation and function of inhibitory synapses in mouse cerebellar Purkinje cells

2014 ◽  
Vol 39 (8) ◽  
pp. 1268-1280 ◽  
Author(s):  
Aya Ito-Ishida ◽  
Wataru Kakegawa ◽  
Kazuhisa Kohda ◽  
Eriko Miura ◽  
Shigeo Okabe ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Inhibitory Synapses ◽  
Cerebellar Purkinje Cells ◽  
And Function

scholarly journals Calsyntenin-3, an atypical cadherin, suppresses inhibitory basket- and stellate-cell synapses but boosts excitatory parallel-fiber synapses in cerebellum

2021 ◽  
Author(s):  
Zhihui Liu ◽  
Man Jiang ◽  
Kif Liakath-Ali ◽  
Jaewon Ko ◽  
Roger Shen Zhang ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Adhesion Molecule ◽  
Synapse Formation ◽  
Stellate Cell ◽  
Parallel Fiber ◽  
Inhibitory Synapses ◽  
New Paradigm ◽  
Synaptic Regulation ◽  
Cerebellar Purkinje Cells

Cadherins contribute to the organization of nearly all tissues, but the functions of several evolutionarily conserved cadherins, including those of calsyntenins, remain enigmatic. Puzzlingly, two distinct, non-overlapping functions for calsyntenins were proposed: As postsynaptic neurexin ligands in synapse formation, or as presynaptic adaptors for kinesin-mediated vesicular transport. Here, we show that acute CRISPR-mediated deletion of calsyntenin-3 in cerebellar Purkinje cells in vivo causes a large decrease in inhibitory synapses, but a surprisingly robust increase in excitatory parallel-fiber synapses. No changes in the dendritic architecture of Purkinje cells or in climbing-fiber synapses were detected. Thus, by promoting formation of an excitatory type of synapses and decreasing formation of an inhibitory type of synapses in the same neuron, calsyntenin-3 functions as a postsynaptic adhesion molecule that regulates the excitatory/inhibitory balance in Purkinje cells. No similarly opposing function of a synaptic adhesion molecule was previously observed, suggesting a new paradigm of synaptic regulation.

Ultrastorcture of Cerebellar Purkinje Cells in Rats Subjected To Partial Global Cerebral Ischemia

1985 ◽  
Vol 43 ◽  
pp. 674-675
Author(s):  
R.V.W. Dimlich ◽  
M.H. Biros
Keyword(s):  
Cerebral Ischemia ◽  
Purkinje Cells ◽  
Cell Types ◽  
Microscopic Level ◽  
Global Cerebral Ischemia ◽  
Light Microscopic Level ◽  
Cerebellar Damage ◽  
Cerebellar Injury ◽  
Cerebellar Purkinje Cells ◽  
Cell Changes

In severe cerebral ischemia, Purkinje cells of the cerebellum are one of the cell types most vulnerable to anoxic damage. In the partial (forebrain) global ischemic (PGI) model of the rat, Paljärvi noted at the light microscopic level that cerebellar damage is inconsistant and when present, milder than in the telencephalon, diencephalon and rostral brain stem. Cerebellar injury was observed in 3 of 4 PGI rats following 5 minutes of reperfusion but in none of the rats after 90 min of reperfusion. To evaluate a time between these two extremes (5 and 90 min), the present investigation used the PGI model to study the effects of ischemia on the ultrastructure of cerebellar Purkinje cells in rats that were sacrificed after 30 min of reperfusion. This time also was chosen because lactic acid that is thought to contribute to ischemic cell changes in PGI is at a maximum after 30 min of reperfusion.

scholarly journals Characterization of starvation-induced autophagy in cerebellar Purkinje cells of pHluorin-mKate2-human LC3B transgenic mice

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Juan Alejandro Oliva Trejo ◽  
Isei Tanida ◽  
Chigure Suzuki ◽  
Soichiro Kakuta ◽  
Norihiro Tada ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Purkinje Cells ◽  
Cerebellar Purkinje Cells
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