scholarly journals Human psychophysics and rodent spinal neurones exhibit peripheral and central mechanisms of inflammatory pain in the UVB and UVB heat rekindling models

2015 ◽  
Vol 593 (17) ◽  
pp. 4029-4042 ◽  
Author(s):  
Jessica O'Neill ◽  
Shafaq Sikandar ◽  
Stephen B. McMahon ◽  
Anthony H. Dickenson
Keyword(s):  
Inflammatory Pain ◽  
Human Psychophysics ◽  
Spinal Neurones

Electrical Acupuncture Efficacy on Inflammatory Pain

2018 ◽  
Vol 28 (3) ◽  
pp. 32
Author(s):  
Minghong SUI ◽  
Jingjing LI ◽  
Yun XIANG ◽  
Guojian SHU ◽  
Dongmei JIN ◽  
...  
Keyword(s):  
Inflammatory Pain ◽  
Electrical Acupuncture

Traditional Chinese Medicine for Managing Inflammatory Pain of Arthritis with Herbal Medicines

2016 ◽  
Vol 2 (2) ◽  
pp. 80-93
Author(s):  
Jieyu Zuo ◽  
Qin Zheng ◽  
Hui Jian ◽  
Tasha Porttin ◽  
Chanelle Willson ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Inflammatory Pain ◽  
Herbal Medicines

Chronic morphine reduces pain-related disability in a rodent model of chronic, inflammatory pain.

1999 ◽  
Vol 7 (3) ◽  
pp. 187-197 ◽  
Author(s):  
Mark D. Lindner ◽  
Melissa A. Plone ◽  
Jonathan M. Francis ◽  
Chris K. Cain
Keyword(s):  
Inflammatory Pain ◽  
Rodent Model ◽  
Chronic Morphine ◽  
Chronic Inflammatory Pain

scholarly journals Purinergic ATP triggers moxibustion-induced local anti-nociceptive effect on inflammatory pain model

2021 ◽  
Author(s):  
Hai-Yan Yin ◽  
Ya-Peng Fan ◽  
Juan Liu ◽  
Dao-Tong Li ◽  
Jing Guo ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Inflammatory Pain ◽  
Analgesic Effect ◽  
Intramuscular Injection ◽  
High Performance ◽  
Atp Hydrolysis ◽  
Purinergic Signalling ◽  
Pain Model ◽  
Speed Up

AbstractPurinergic signalling adenosine and its A1 receptors have been demonstrated to get involved in the mechanism of acupuncture (needling therapy) analgesia. However, whether purinergic signalling would be responsible for the local analgesic effect of moxibustion therapy, the predominant member in acupuncture family procedures also could trigger analgesic effect on pain diseases, it still remains unclear. In this study, we applied moxibustion to generate analgesic effect on complete Freund’s adjuvant (CFA)-induced inflammatory pain rats and detected the purine released from moxibustioned-acupoint by high-performance liquid chromatography (HPLC) approach. Intramuscular injection of ARL67156 into the acupoint Zusanli (ST36) to inhibit the breakdown of ATP showed the analgesic effect of moxibustion was increased while intramuscular injection of ATPase to speed up ATP hydrolysis caused a reduced moxibustion-induced analgesia. These data implied that purinergic ATP at the location of ST36 acupoint is a potentially beneficial factor for moxibustion-induced analgesia.

scholarly journals Mechanisms and Mediators of Pain in Chronic Inflammatory Arthritis

2021 ◽  
Author(s):  
Marco Di Carlo ◽  
Gianluca Smerilli ◽  
Fausto Salaffi
Keyword(s):  
Inflammatory Pain ◽  
Inflammatory Arthritis ◽  
Operational Definition ◽  
Immunosuppressive Drugs ◽  
Therapeutic Strategies ◽  
Future Research ◽  
Common Symptom ◽  
Joint Diseases ◽  
Chronic Inflammatory Arthritis ◽  
Inflammatory Joint Diseases

Abstract Purpose of the review Pain in chronic inflammatory joint diseases is a common symptom reported by patients. Pain becomes of absolute clinical relevance especially when it becomes chronic, i.e., when it persists beyond normal healing times. As an operational definition, pain is defined chronic when it lasts for more than 3 months. This article aims to provide a review of the main mechanisms underlying pain in patients with chronic inflammatory joint diseases, discussing in particular their overlap. Recent findings While it may be intuitive how synovial inflammation or enthesitis are responsible for nociceptive pain, in clinical practice, it is common to find patients who continue to complain of symptoms despite optimal control of inflammation. In this kind of patients at the genesis of pain, there may be neuropathic or nociplastic mechanisms. Summary In the context of chronic inflammatory joint diseases, multiple mechanisms generally coexist behind chronic pain. It is the rheumatologist’s task to identify the mechanisms of pain that go beyond the nociceptive mechanisms, to adopt appropriate therapeutic strategies, including avoiding overtreatment of patients with immunosuppressive drugs. In this sense, future research will have to be oriented to search for biomarkers of non-inflammatory pain in patients with chronic inflammatory joint diseases.

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