Determinants of Oxygen Uptake Kinetics in Older Humans Following Single-Limb Endurance Exercise Training

2001 ◽  
Vol 86 (5) ◽  
pp. 659-665 ◽  
Author(s):  
Christopher Bell ◽  
Donald H. Paterson ◽  
John M. Kowalchuk ◽  
Andrew P. Moy ◽  
David B. Thorp ◽  
...  
Keyword(s):  
Exercise Training ◽  
Oxygen Uptake ◽  
Endurance Exercise ◽  
Oxygen Uptake Kinetics ◽  
Uptake Kinetics ◽  
Endurance Exercise Training

Exercise training enhances leg vasodilatory capacity of 65-yr-old men and women

1990 ◽  
Vol 69 (5) ◽  
pp. 1804-1809 ◽  
Author(s):  
W. H. Martin ◽  
W. M. Kohrt ◽  
M. T. Malley ◽  
E. Korte ◽  
S. Stoltz
Keyword(s):  
Blood Flow ◽  
Body Weight ◽  
Exercise Training ◽  
Oxygen Uptake ◽  
Endurance Exercise ◽  
Maximal Oxygen Uptake ◽  
Statistical Significance ◽  
Tissue Loss ◽  
Leg Blood Flow ◽  
Endurance Exercise Training

To determine whether extremity vasodilatory capacity may be augmented in older persons by endurance exercise training, lower leg blood flow and conductance were characterized plethysmographically at rest and during maximal hyperemia in 9 men and 10 women aged 64 +/- 3 (SD) yr before and after 31 +/- 6 wk of walking and jogging at 70-90% of maximal oxygen uptake for 45 min 3-5 days/wk. Maximal oxygen uptake expressed as milliliters per kilogram per minute improved 25% in men and 21% in women (P less than 0.01). Maximal leg blood flow and conductance increased in all nine men by an average of 39 +/- 33 (P less than 0.001) and 42 +/- 44% (P less than 0.004), respectively. Results were more variable in women and achieved unequivocal statistical significance only for maximal blood flow (+33 +/- 54% for blood flow and +29 +/- 55% for conductance; P less than 0.02 and P = 0.05, respectively). Body weight and skinfold adiposity declined in both sexes (P less than 0.05). Enhancement of vasodilatory capacity was related to weight loss in men and adipose tissue loss in women (r = 0.61 and 0.51, respectively; P less than 0.05). There were no significant changes in exercise capacity, body weight, or maximal blood flow in four male and three female controls aged 66 +/- 4 yr. Thus adaptability of the lower limb circulation to endurance exercise training is retained to at least age 65 yr.

The Effects of Exercise Training on Oxygen Uptake Kinetics in Post-menopausal Women

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S221
Author(s):  
Liza Stathokostas ◽  
John M. Kowalchuk ◽  
Robert J. Petrella ◽  
Donald H. Paterson
Keyword(s):  
Exercise Training ◽  
Oxygen Uptake ◽  
Oxygen Uptake Kinetics ◽  
Uptake Kinetics ◽  
Menopausal Women ◽  
Post Menopausal

scholarly journals PBMCs express a transcriptome signature predictor of oxygen uptake responsiveness to endurance exercise training in men

2015 ◽  
Vol 47 (2) ◽  
pp. 13-23 ◽  
Author(s):  
Rodrigo Gonçalves Dias ◽  
Michelle Sabrina Moreira Silva ◽  
Nubia Esteban Duarte ◽  
Wladimir Bolani ◽  
Cleber Renê Alves ◽  
...  
Keyword(s):  
Gene Expression ◽  
Exercise Training ◽  
Oxygen Uptake ◽  
Endurance Training ◽  
Endurance Exercise ◽  
Peripheral Blood ◽  
Functional Enrichment ◽  
Total Rna ◽  
Transcriptional Signature ◽  
Endurance Exercise Training

Peripheral blood cells are an accessible environment in which to visualize exercise-induced alterations in global gene expression patterns. We aimed to identify a peripheral blood mononuclear cell (PBMC) signature represented by alterations in gene expression, in response to a standardized endurance exercise training protocol. In addition, we searched for molecular classifiers of the variability in oxygen uptake (V̇o2). Healthy untrained policemen recruits ( n = 13, 25 ± 3 yr) were selected. Peak V̇o2 (measured by cardiopulmonary exercise testing) and total RNA from PBMCs were obtained before and after 18 wk of running endurance training (3 times/wk, 60 min). Total RNA was used for whole genome expression analysis using Affymetrix GeneChip Human Gene 1.0 ST. Data were normalized by the robust multiarray average algorithm. Principal component analysis was used to perform correlations between baseline gene expression and V̇o2peak. A set of 211 transcripts was differentially expressed (ANOVA, P < 0.05 and fold change > 1.3). Functional enrichment analysis revealed that transcripts were mainly related to immune function, cell cycle processes, development, and growth. Baseline expression of 98 and 53 transcripts was associated with the absolute and relative V̇o2peak response, respectively, with a strong correlation ( r > 0.75, P < 0.01), and this panel was able to classify the 13 individuals according to their potential to improve oxygen uptake. A subset of 10 transcripts represented these signatures to a similar extent. PBMCs reveal a transcriptional signature responsive to endurance training. Additionally, a baseline transcriptional signature was associated with changes in V̇o2peak. Results might illustrate the possibility of obtaining molecular classifiers of endurance capacity changes through a minimally invasive blood sampling procedure.

Effect of Exercise Training on Postexercise Oxygen Uptake Kinetics in Patients With Reduced Ventricular Function

CHEST Journal ◽  
2001 ◽  
Vol 120 (4) ◽  
pp. 1206-1211 ◽  
Author(s):  
Jonathan Myers ◽  
Renato Gianrossi ◽  
Juerg Schwitter ◽  
Doris Wagner ◽  
Paul Dubach
Keyword(s):  
Exercise Training ◽  
Oxygen Uptake ◽  
Ventricular Function ◽  
Oxygen Uptake Kinetics ◽  
Uptake Kinetics
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