scholarly journals Melanotan II, a melanocortin agonist, partially rescues the impaired thermogenic capacity of pituitary adenylate cyclase‐activating polypeptide deficient mice

2020 ◽  
Author(s):  
Thecla Rae McMillan ◽  
Maeghan A. M. Forster ◽  
Landon I. Short ◽  
Alexander P. Rudecki ◽  
Daemon L. Cline ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Pituitary Adenylate Cyclase ◽  
Deficient Mice ◽  
Thermogenic Capacity ◽  
Melanotan Ii

scholarly journals Backup Mechanisms Maintain PACAP/VIP-Induced Arterial Relaxations in Pituitary Adenylate Cyclase-Activating Polypeptide-Deficient Mice

2017 ◽  
Vol 54 (3) ◽  
pp. 180-192 ◽  
Author(s):  
Ivan Ivic ◽  
Balazs D. Fulop ◽  
Tamas Juhasz ◽  
Dora Reglodi ◽  
Gabor Toth ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Pituitary Adenylate Cyclase ◽  
Deficient Mice

Altered Notch Signaling in Developing Molar Teeth of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)-Deficient Mice

2018 ◽  
Vol 68 (3) ◽  
pp. 377-388 ◽  
Author(s):  
B. D. Fulop ◽  
B. Sandor ◽  
E. Szentleleky ◽  
E. Karanyicz ◽  
D. Reglodi ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Notch Signaling ◽  
Pituitary Adenylate Cyclase ◽  
Molar Teeth ◽  
Deficient Mice

scholarly journals Pulmonary Hypertension and Right Heart Failure in Pituitary Adenylate Cyclase–Activating Polypeptide Type I Receptor–Deficient Mice

Circulation ◽  
2004 ◽  
Vol 110 (20) ◽  
pp. 3245-3251 ◽  
Author(s):  
Christiane Otto ◽  
Lutz Hein ◽  
Marc Brede ◽  
Roland Jahns ◽  
Stefan Engelhardt ◽  
...  
Keyword(s):  
Heart Failure ◽  
Pulmonary Hypertension ◽  
Adenylate Cyclase ◽  
Right Heart Failure ◽  
Type I ◽  
Right Heart ◽  
Pituitary Adenylate Cyclase ◽  
Deficient Mice

Role of endogenous pituitary adenylate cyclase activating polypeptide (PACAP) in myelination of the rodent brain: Lessons from PACAP‐deficient mice

2011 ◽  
Vol 29 (8) ◽  
pp. 923-935 ◽  
Author(s):  
András Vincze ◽  
Dóra Reglodi ◽  
Zsuzsanna Helyes ◽  
Hitoshi Hashimoto ◽  
Norihito Shintani ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Rodent Brain ◽  
Pituitary Adenylate Cyclase ◽  
Deficient Mice

Pituitary adenylate cyclase-activating polypeptide maintains neonatal breathing but not metabolism during mild reductions in ambient temperature

2008 ◽  
Vol 294 (3) ◽  
pp. R956-R965 ◽  
Author(s):  
Kevin J. Cummings ◽  
Chris Willie ◽  
Richard J. A. Wilson
Keyword(s):  
Body Temperature ◽  
Adenylate Cyclase ◽  
Metabolic Rate ◽  
Ambient Temperature ◽  
Tidal Volume ◽  
Ambient Temperatures ◽  
Ventilatory Responses ◽  
Pituitary Adenylate Cyclase ◽  
Flow Through ◽  
Deficient Mice

Mild reductions in ambient temperature dramatically increase the mortality of neonatal mice deficient in pituitary adenylate cyclase-activating polypeptide (PACAP), with the majority of animals succumbing in the second postnatal week. During anesthesia-induced hypothermia, PACAP−/− mice at this age are also vulnerable to prolonged apneas and sudden death. From these observations, we hypothesized that before the onset of genotype-specific mortality and in the absence of anesthetic, the breathing of PACAP-deficient mice is more susceptible to mild reductions in ambient temperature than wild-type littermates. To test this hypothesis, we recorded breathing in one group of postnatal day 4 PACAP+/+, +/−, and −/− neonates (using unrestrained, flow-through plethysmography) and metabolic rate in a separate group (using indirect calorimetry), both of which were exposed acutely to ambient temperatures slightly below (29°C), slightly above (36°C), or at thermoneutrality (32°C). At 32°C, the breathing frequency of PACAP−/− neonates was significantly less than PACAP+/+ littermates. Reducing the ambient temperature to 29°C caused a significant suppression of tidal volume and ventilation in both PACAP+/− and −/− animals, while the tidal volume and ventilation of PACAP+/+ animals remained unchanged. Genotype had no effect on the ventilatory responses to ambient warming. At all three ambient temperatures, genotype had no influence on oxygen consumption or body temperature. These results suggest that during mild reductions in ambient temperature, PACAP is vital for the preservation of neonatal tidal volume and ventilation, but not for metabolic rate or body temperature.

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