Alterations in resting cerebrovascular regulation do not affect reactivity to hypoxia, hyperoxia or neurovascular coupling following a SCUBA dive

2020 ◽  
Vol 105 (9) ◽  
pp. 1540-1549
Author(s):  
Hannah G. Caldwell ◽  
Ryan L. Hoiland ◽  
Otto F. Barak ◽  
Tanja Mijacika ◽  
Joel S. Burma ◽  
...  
Keyword(s):  
Neurovascular Coupling ◽  
Affect Reactivity ◽  
Cerebrovascular Regulation

Negative neurovascular coupling during anoxic depolarization and peri-infarct spreading depressions in acute focal cerebral ischemia in mice

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S425-S425
Author(s):  
Cenk Ayata ◽  
Hwa Kyoung Shin ◽  
Phillip Jones ◽  
Andrew K Dunn ◽  
David A Boas ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Neurovascular Coupling ◽  
Anoxic Depolarization

scholarly journals Cerebral autoregulation and neurovascular coupling are progressively impaired during septic shock: an experimental study

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Lorenzo Ferlini ◽  
Fuhong Su ◽  
Jacques Creteur ◽  
Fabio Silvio Taccone ◽  
Nicolas Gaspard
Keyword(s):  
Experimental Study ◽  
Septic Shock ◽  
Cerebral Autoregulation ◽  
Neurovascular Coupling

scholarly journals Diversity of neurovascular coupling dynamics along vascular arbors in layer II/III somatosensory cortex

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Ravi L. Rungta ◽  
Marc Zuend ◽  
Ali-Kemal Aydin ◽  
Éric Martineau ◽  
Davide Boido ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Somatosensory Cortex ◽  
Cerebral Blood Volume ◽  
Transfer Functions ◽  
Neurovascular Coupling ◽  
Sensory Stimulation ◽  
Brain Regions ◽  
Blood Velocity ◽  
Functional Brain Imaging ◽  
Vascular Events

AbstractThe spatial-temporal sequence of cerebral blood flow (CBF), cerebral blood volume (CBV) and blood velocity changes triggered by neuronal activation is critical for understanding functional brain imaging. This sequence follows a stereotypic pattern of changes across different zones of the vasculature in the olfactory bulb, the first relay of olfaction. However, in the cerebral cortex, where most human brain mapping studies are performed, the timing of activity evoked vascular events remains controversial. Here we utilized a single whisker stimulation model to map out functional hyperemia along vascular arbours from layer II/III to the surface of primary somatosensory cortex, in anesthetized and awake Thy1-GCaMP6 mice. We demonstrate that sensory stimulation triggers an increase in blood velocity within the mid-capillary bed and a dilation of upstream large capillaries, and the penetrating and pial arterioles. We report that under physiological stimulation, response onset times are highly variable across compartments of different vascular arbours. Furthermore, generating transfer functions (TFs) between neuronal Ca2+ and vascular dynamics across different brain states demonstrates that anesthesia decelerates neurovascular coupling (NVC). This spatial-temporal pattern of vascular events demonstrates functional diversity not only between different brain regions but also at the level of different vascular arbours within supragranular layers of the cerebral cortex.

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