scholarly journals Regional contributions of nitric oxide synthase to cholinergic cutaneous vasodilatation and sweating in young men

2020 ◽  
Vol 105 (2) ◽  
pp. 236-243
Author(s):  
Gregory W. McGarr ◽  
Reem Ghassa ◽  
Naoto Fujii ◽  
Tatsuro Amano ◽  
Glen P. Kenny
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Young Men ◽  
Cutaneous Vasodilatation ◽  
Oxide Synthase

scholarly journals Activation of protease-activated receptor 2 mediates cutaneous vasodilatation but not sweating: roles of nitric oxide synthase and cyclo-oxygenase

2017 ◽  
Vol 102 (2) ◽  
pp. 265-272 ◽  
Author(s):  
Naoto Fujii ◽  
Brendan D. McNeely ◽  
Sarah Y. Zhang ◽  
Yasmine C. Abdellaoui ◽  
Mercy O. Danquah ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Cutaneous Vasodilatation ◽  
Protease Activated Receptor 2 ◽  
Oxide Synthase

scholarly journals β-Adrenergic-mediated vasodilation in young men and women: cyclooxygenase restrains nitric oxide synthase

2016 ◽  
Vol 310 (6) ◽  
pp. H756-H764 ◽  
Author(s):  
Jacqueline K. Limberg ◽  
Rebecca E. Johansson ◽  
Garrett L. Peltonen ◽  
John W. Harrell ◽  
J. Mikhail Kellawan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Nitric Oxide Synthase ◽  
Young Men ◽  
Vascular Conductance ◽  
Men And Women ◽  
Local Inhibition ◽  
Before And After ◽  
Health And Disease ◽  
Oxide Synthase

We tested the hypothesis that women exhibit greater vasodilator responses to β-adrenoceptor stimulation compared with men. We further hypothesized women exhibit a greater contribution of nitric oxide synthase and cyclooxygenase to β-adrenergic-mediated vasodilation compared with men. Forearm blood flow (Doppler ultrasound) was measured in young men ( n = 29, 26 ± 1 yr) and women ( n = 33, 25 ± 1 yr) during intra-arterial infusion of isoproterenol (β-adrenergic agonist). In subset of subjects, isoproterenol responses were examined before and after local inhibition of nitric oxide synthase [ NG-monomethyl-l-arginine (l-NMMA); 6 male/10 female] and/or cyclooxygenase (ketorolac; 5 male/5 female). Vascular conductance (blood flow ÷ mean arterial pressure) was calculated to assess vasodilation. Vascular conductance increased with isoproterenol infusion ( P < 0.01), and this effect was not different between men and women ( P = 0.41). l-NMMA infusion had no effect on isoproterenol-mediated dilation in men ( P > 0.99) or women ( P = 0.21). In contrast, ketorolac infusion markedly increased isoproterenol-mediated responses in both men ( P < 0.01) and women ( P = 0.04) and this rise was lost with subsequent l-NMMA infusion (men, P < 0.01; women, P < 0.05). β-Adrenergic vasodilation is not different between men and women and sex differences in the independent contribution of nitric oxide synthase and cyclooxygenase to β-mediated vasodilation are not present. However, these data are the first to demonstrate β-adrenoceptor activation of cyclooxygenase suppresses nitric oxide synthase signaling in human forearm microcirculation and may have important implications for neurovascular control in both health and disease.

scholarly journals Contribution of nitric oxide synthase to cutaneous vasodilatation and sweating in men of black‐African and Caucasian descent during exercise in the heat

2019 ◽  
Vol 104 (12) ◽  
pp. 1762-1768 ◽  
Author(s):  
Caroline M. Muia ◽  
Gregory W. McGarr ◽  
Madison D. Schmidt ◽  
Naoto Fujii ◽  
Tatsuro Amano ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Black African ◽  
Cutaneous Vasodilatation ◽  
Oxide Synthase

Localization of endothelial nitric oxide synthase in the normal and failing human atrial myocardium

1996 ◽  
Vol 54 ◽  
pp. 786-787
Author(s):  
Chi-Ming Wei ◽  
Margarita Bracamonte ◽  
Shi-Wen Jiang ◽  
Richard C. Daly ◽  
Christopher G.A. McGregor ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Cardiac Tissues ◽  
Mammalian Tissues ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).

Nitric oxide synthase and cellac disease

2001 ◽  
Vol 120 (5) ◽  
pp. A684-A684
Author(s):  
I DANIELS ◽  
I MURRAY ◽  
W GODDARD ◽  
R LONG
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Oxide Synthase
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