scholarly journals Hypercapnia augments resistive exercise‐induced elevations in intraocular pressure in older individuals

2020 ◽  
Vol 105 (4) ◽  
pp. 641-651 ◽  
Author(s):  
Igor B. Mekjavic ◽  
Winfried Amoaku ◽  
Tinkara Mlinar ◽  
Polona Jaki Mekjavic
Keyword(s):  
Intraocular Pressure ◽  
Older Individuals ◽  
Resistive Exercise ◽  
Exercise Induced

scholarly journals Lower Leg Chronic Exertional Compartment Syndrome in Patients 50 Years of Age and Older

2018 ◽  
Vol 6 (3) ◽  
pp. 232596711875717 ◽  
Author(s):  
Johan A. de Bruijn ◽  
Aniek P.M. van Zantvoort ◽  
Michiel B. Winkes ◽  
Marike van der Cruijsen-Raaijmakers ◽  
Adwin R. Hoogeveen ◽  
...  
Keyword(s):  
Compartment Syndrome ◽  
Older Patients ◽  
Lower Leg ◽  
Leg Pain ◽  
Older Individuals ◽  
Younger Patients ◽  
Chronic Exertional Compartment Syndrome ◽  
Exertional Compartment Syndrome ◽  
Exercise Induced ◽  
Lower Leg Pain

Background: Lower leg chronic exertional compartment syndrome (CECS) is usually diagnosed in young and athletic individuals. The presence of CECS in older patients has received little attention in the literature, and patient characteristics are unknown. Purpose: To determine the prevalence of CECS in older patients (≥50 years) and to assess whether older patients with CECS differ clinically from younger patients with CECS. Study Design: Cohort study; Level of evidence, 3. Methods: All individuals with exercise-induced lower leg pain who visited a referral center for CECS between January 2001 and December 2013 were eligible for analysis. Patients were included if history, physical examination, and dynamic intracompartmental pressure measurement indicated CECS. Characteristics of patients 50 years of age or older were compared with characteristics of patients younger than 50. Results: A total of 698 patients with CECS were included: 98 patients were aged 50 years or older and 600 patients were younger than 50 years. Older individuals more often reported a history of lower leg events or comorbidities (≥50 years, 45% vs <50 years, 25%; P < .01) and unilateral symptoms (≥50 years, 45% vs <50 years, 22%; P < .01). Most older patients (62%) did not participate in sport or only walked or hiked, whereas the same was true of only 7% of the younger population. Pain (≥50 years, 94%; <50 years, 96%) and tightness (≥50 years, 57%; <50 years, 62%) were the predominant symptoms of CECS in both groups. Type of CECS differed significantly ( P < .01); the anterior muscle compartment was involved more frequently in older patients (≥50 years, 82% vs <50 years, 59%) and deep flexor muscle CECS was more often diagnosed in younger patients (≥50 years, 26% vs <50 years, 53%). Conclusion: In the present population, 1 in 7 patients diagnosed with lower leg CECS was 50 years of age or older. These individuals were less active and had more comorbidities than patients younger than 50 years. Older individuals predominantly have anterior CECS. Clinicians should consider CECS in older individuals with exercise-induced lower leg pain, particularly if it is unilateral.

Exercise-Induced Increase of Intraocular Pressure in the Pigmentary Dispersion Syndrome

1980 ◽  
Vol 89 (4) ◽  
pp. 598-600 ◽  
Author(s):  
Howard I. Schenker ◽  
Maurice H. Luntz ◽  
Barry Kels ◽  
Steven M. Podos
Keyword(s):  
Intraocular Pressure ◽  
Exercise Induced

scholarly journals The Effects of Age and Latent Cytomegalovirus Infection on NK-Cell Phenotype and Exercise Responsiveness in Man

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Austin B. Bigley ◽  
Guillaume Spielmann ◽  
Nadia Agha ◽  
Richard J. Simpson
Keyword(s):  
Nk Cells ◽  
Nk Cell ◽  
The Body ◽  
Cell Phenotype ◽  
Older Individuals ◽  
Acute Bout ◽  
Age Dependent ◽  
Fight Or Flight Response ◽  
Differentiation Marker ◽  
Exercise Induced

The redeployment of NK-cells in response to an acute bout of exercise is thought to be an integral component of the “fight-or-flight” response, preparing the body for potential injury or infection. We showed previously that CMV seropositivity impairs the redeployment of NK-cells with exercise in the young. In the current study, we examined the effect of aging on the redeployment of NK-cells with exercise in the context of CMV. We show here that CMV blunts the exercise-induced redeployment of NK-cells in both younger (23–39 yrs) and older (50–64 yrs) subjects with olderCMVnegsubjects showing the largest postexercise mobilization and 1 h postexercise egress of NK-cells. The blunted exercise response inCMVposindividuals was associated with a decreased relative redeployment of the CD158a+ and CD57+ NK-cell subsets in younger and older individuals. In addition, we show that aging is associated with a CMV-independent increase in the proportion of NK-cells expressing the terminal differentiation marker CD57, while CMV is associated with an age-dependent decrease in the proportion of NK-cells expressing the inhibitory receptors KLRG1 (in the younger group) and CD158a (in the older group). Collectively, these data suggest that CMV may decrease NK-cell mediated immunosurveillance after exercise in both younger and older individuals.

Effect of Glycosylated Steroid from Panax Notoginseng on Resistive Exercise-Induced Muscle Damage

2014 ◽  
Vol 46 ◽  
pp. 732
Author(s):  
Te-Chih Liu ◽  
Chia-Hua Kuo ◽  
John L. Ivy ◽  
Fang-Yi Cheng ◽  
Shih-Hsien Cheng
Keyword(s):  
Muscle Damage ◽  
Panax Notoginseng ◽  
Resistive Exercise ◽  
Exercise Induced

scholarly journals Protective effects of acute exercise preconditioning on disuse-induced muscular atrophy in aged muscle: a narrative literature review

2020 ◽  
Vol 70 (1) ◽  
Author(s):  
Toshinori Yoshihara ◽  
Hisashi Naito
Keyword(s):  
Skeletal Muscle ◽  
Acute Exercise ◽  
Muscular Atrophy ◽  
Protective Effects ◽  
Older Individuals ◽  
Age Related ◽  
Exercise Preconditioning ◽  
Narrative Literature Review ◽  
Exercise Induced ◽  
Effects Of Aging

AbstractAging is associated with a progressive loss of skeletal muscle mass and strength, resulting in frailty and lower quality of life in older individuals. At present, a standard of clinical or pharmacological care to prevent the adverse effects of aging does not exist. Determining the mechanism(s) responsible for muscular atrophy in disused aged muscle is a required key step for the development of effective countermeasures. Studies suggest an age-related differential response of genes and signalings to muscle disuse in both rodents and humans, implying the possibility that effective countermeasures to prevent disuse muscle atrophy may be age-specific. Notably, exercise preconditioning can attenuate disuse-induced muscular atrophy in rodent and human skeletal muscles; however, information on age-specific mechanisms of this exercise-induced protection remains limited. This mini-review aimed to summarize the protective effects of acute exercise preconditioning on muscular atrophy in aged muscle and provide potential mechanisms for its preventive effect on skeletal muscle wasting.

AB080. Exercise induced changes in intraocular pressure is related to systemic dehydration

2018 ◽  
Vol 3 ◽  
pp. AB080-AB080
Author(s):  
Jean-Marie Hanssens ◽  
Gabrielle Roddy ◽  
Dave Ellenberg
Keyword(s):  
Intraocular Pressure ◽  
Exercise Induced ◽  
Induced Changes

Exercise- and hypoxia-induced blood flow through intrapulmonary arteriovenous anastomoses is reduced in older adults

2014 ◽  
Vol 116 (10) ◽  
pp. 1324-1333 ◽  
Author(s):  
H. Cameron Norris ◽  
Tyler S. Mangum ◽  
Joseph W. Duke ◽  
Taylor B. Straley ◽  
Jerold A. Hawn ◽  
...  
Keyword(s):  
Blood Flow ◽  
Contrast Echocardiography ◽  
Age Groups ◽  
Systolic Pressure ◽  
Arteriovenous Anastomoses ◽  
Older Individuals ◽  
Age Related ◽  
Flow Through ◽  
Pulmonary Arterial ◽  
Exercise Induced

Mean pulmonary arterial pressure (Ppa) during exercise is significantly higher in individuals aged ≥50 yr compared with their younger counterparts, but the reasons for this are unknown. Blood flow through intrapulmonary arteriovenous anastomoses (IPAVA) can be detected during exercise or while breathing hypoxic gas mixtures using saline contrast echocardiography in almost all healthy young individuals. It has been previously hypothesized that a lower degree of exercise-induced blood flow through IPAVA is associated with high Ppa during exercise. This association may suggest that individuals who are known to have high Ppa during exercise, such as those ≥50 yr of age, may have lower blood flow through IPAVA, but the presence and degree of exercise-induced blood flow through IPAVA has not been specifically studied in older populations. Using transthoracic saline contrast echocardiography, we investigated the potential effects of age on exercise-induced blood flow through IPAVA in a cross-section of subjects aged 19–72 yr. To verify our findings, we assessed the effects of age on hypoxia-induced blood flow through IPAVA. Age groups were ≤41 yr (younger, n = 16) and ≥50 yr (older, n = 14). Qualitatively measured exercise- and hypoxia-induced blood flow through IPAVA was significantly lower in older individuals compared with younger controls. Older individuals also had significantly higher pulmonary arterial systolic pressure and total pulmonary resistance (TPR) during exercise. Low blood flow through IPAVA was independently associated with high TPR. The reasons for the age-related decrease in blood flow through IPAVA are unknown.

The exercise-induced stress response in skeletal muscle: failure during aging

2008 ◽  
Vol 33 (5) ◽  
pp. 1033-1041 ◽  
Author(s):  
Anna C. Kayani ◽  
James P. Morton ◽  
Anne McArdle
Keyword(s):  
Skeletal Muscle ◽  
Stress Response ◽  
Contractile Activity ◽  
Older Individuals ◽  
Adult Skeletal Muscle ◽  
Induced Stress ◽  
Exercise Induced ◽  
Shock Proteins ◽  
Exercise And Training ◽  
And Training

Mammalian adult skeletal muscle adapts to the stress of contractile activity with increased gene expression by yielding a family of highly conserved cytoprotective proteins known as heat shock proteins (HSPs). Although the exercise-induced stress response of both animal and human skeletal muscle is now well documented, the precise mechanisms underlying this adaptation remain unclear. The induction of HSPs after exercise is severely blunted in the muscle of older individuals. This review focuses on the effects of different forms of exercise and training on the induction of HSPs in the muscles of adult individuals, and examines the proposed mechanisms underlying this adaptation. Furthermore, the functional effect of the inability of the muscles of older individuals to adapt in this way is discussed, together with the proposed mechanisms underlying this maladaptation.

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