scholarly journals Pro‐contractile role of chloride in arterial smooth muscle: Postnatal decline potentially governed by sympathetic nerves

2019 ◽  
Vol 104 (7) ◽  
pp. 1018-1022 ◽  
Author(s):  
Daria S. Kostyunina ◽  
Dina K. Gaynullina ◽  
Vladimir V. Matchkov ◽  
Olga S. Tarasova
Keyword(s):  
Smooth Muscle ◽  
Sympathetic Nerves ◽  
Arterial Smooth Muscle

Atherogenic Activity caused by Excess Membrane Cholesterol in Arterial Smooth Muscle: Role of Calcium Channels

1993 ◽  
pp. 107-115 ◽  
Author(s):  
Thomas N. Tulenko ◽  
R. Preston Mason ◽  
Meng Chen ◽  
Hiromi Tasaki ◽  
Daniel Rock ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Calcium Channels ◽  
Membrane Cholesterol ◽  
Arterial Smooth Muscle

scholarly journals The non-obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

2008 ◽  
Author(s):  
Igor Buchwalow ◽  
Sona Cacanyiova ◽  
Joachim Neumann ◽  
Vera Samoilova ◽  
Werner Boecker ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Smooth Muscle ◽  
Arterial Smooth Muscle

scholarly journals An Investigation Into the Role of Osteocalcin in Human Arterial Smooth Muscle Cell Calcification

2020 ◽  
Vol 11 ◽  
Author(s):  
Sophie A. Millar ◽  
Stephen G. John ◽  
Christopher W. McIntyre ◽  
Vera Ralevic ◽  
Susan I. Anderson ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Arterial Smooth Muscle Cell ◽  
Arterial Smooth Muscle

scholarly journals Sympathetic nerves and the endothelium influence the vasoconstrictor effect of low concentrations of ouabain in pressurized small arteries

2010 ◽  
Vol 298 (6) ◽  
pp. H2093-H2101 ◽  
Author(s):  
Hema Raina ◽  
Qingli Zhang ◽  
Albert Y. Rhee ◽  
Thomas L. Pallone ◽  
W. Gil Wier
Keyword(s):  
Smooth Muscle ◽  
Sympathetic Nerve ◽  
Arterial Wall ◽  
Sympathetic Nerves ◽  
Nerve Terminals ◽  
Arterial Smooth Muscle ◽  
Low Concentrations ◽  
Endogenous Ouabain ◽  
Adrenoceptor Blocker ◽  
Arterial Endothelium

We hypothesized that in salt-dependent forms of hypertension, endogenous ouabain acts on arterial smooth muscle to cause enhanced vasoconstriction. Here, we tested for the involvement of the arterial endothelium and perivascular sympathetic nerve terminals in ouabain-induced vasoconstriction. Segments of rat mesenteric or renal interlobar arteries were pressurized to 70 mmHg at 37°C and exposed to ouabain (10−11–10−7 M). Removal of the endothelium enhanced ouabain-induced vasoconstriction by as much as twofold (at an ouabain concentration of 10−9 M). A component of the ouabain-induced vasoconstriction is due to the enhanced spontaneous release of norepinephrine (NE) from nerve terminals in the arterial wall. The α1-adrenoceptor blocker prazosin (10−6 M) decreased ouabain-induced vasoconstrictions by as much as 50%. However, neither the contraction induced by sympathetic nerve activity (SNA) nor the NE release evoked by SNA (measured directly by carbon fiber amperometry) was increased by ouabain (<10−7 M). Nevertheless, the converse case was true: after brief bursts of SNA, vasoconstrictor responses to ouabain were transiently increased (1.75-fold). This effect may be mediated by neuropeptide Y and Y1 receptors on smooth muscle. In arteries lacking the endothelium and exposed to prazosin, ouabain (10−11 M and greater) caused vasoconstriction, indicating a direct effect of very “low” concentrations of ouabain on arterial smooth muscle. In conclusion, in intact arteries, the endothelium opposes ouabain (10−11–10−7M)-induced vasoconstriction, which is caused by both enhanced spontaneous NE release and direct effects on smooth muscle. Ouabain (<10−7M) does not enhance SNA-mediated contractions, but SNA enhances ouabain-induced contractions. The effects of endogenous ouabain may be accentuated in forms of hypertension that involve sympathetic nerve hyperactivity and/or endothelial dysfunction.

Functional role of endothelin ETA and ETB receptors in venous and arterial smooth muscle

1995 ◽  
Vol 287 (3) ◽  
pp. 279-285 ◽  
Author(s):  
Nicholas J. Lodge ◽  
Rongan Zhang ◽  
Nelly N. Halaka ◽  
Suzanne Moreland
Keyword(s):  
Smooth Muscle ◽  
Functional Role ◽  
Arterial Smooth Muscle

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

Nature ◽  
1980 ◽  
Vol 288 (5789) ◽  
pp. 373-376 ◽  
Author(s):  
Robert F. Furchgott ◽  
John V. Zawadzki
Keyword(s):  
Endothelial Cells ◽  
Smooth Muscle ◽  
Arterial Smooth Muscle
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