scholarly journals Fetal sheep central haemodynamics and cardiac function during occlusion of the ascending aorta

2017 ◽  
Vol 103 (1) ◽  
pp. 58-67
Author(s):  
Heikki Huhta ◽  
Juulia Junno ◽  
Mervi Haapsamo ◽  
Tiina Erkinaro ◽  
Pasi Ohtonen ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Ascending Aorta ◽  
Fetal Sheep

Cardiac function in fetal sheep during two weeks of hypoxemia

1994 ◽  
Vol 266 (6) ◽  
pp. R1778-R1785 ◽  
Author(s):  
M. Kamitomo ◽  
L. D. Longo ◽  
R. D. Gilbert
Keyword(s):  
Arterial Pressure ◽  
Cardiac Function ◽  
Ventricular Function ◽  
Left Ventricular ◽  
Pressure Sensitivity ◽  
Sensitivity Curve ◽  
Fetal Sheep ◽  
Cardiac Responses ◽  
Ovine Fetal

Although several studies have examined fetal cardiac responses to acute hypoxemia, relatively little is known of the response to prolonged hypoxemia. To determine the effects of long-term hypoxemia on ovine fetal cardiac function, we measured right (QRV) and left ventricular outputs (QLV) and determined the effects of increasing preload (ventricular function curve) and afterload (arterial pressure sensitivity curve) on the left ventricle. Six days after fetal surgical instrumentation with catheters and electromagnetic flow probes (approximately 123 days gestation), we administered N2 into the maternal trachea for 14 days to reduce maternal PO2 to approximately 55 Torr (hypoxemic group, Hyp, n = 6). Normoxic animals were used as controls (Cont, n = 6). With the onset of hypoxemia, fetal arterial PO2 was reduced from approximately 27 to approximately 18 Torr. Fetal heart rate in Hyp fetuses decreased approximately 22% on day 14 compared with Cont (P < 0.05). Mean arterial pressure in the Hyp group was higher than that of Cont but not significantly so. Right and left atrial pressures were not affected by hypoxemia. QRV in Hyp fetuses was maintained on day 1 but decreased significantly by day 3 (approximately 19%) and further decreased on days 7 (approximately 28%) and 14 (approximately 34%). QLV was not depressed until day 7 (approximately 20%), with a further decrease on day 14 (approximately 38%). In association with the decreased QLV the plateau of the ventricular function curve in Hyp fetuses was depressed significantly on days 7 and 14. In contrast, the slope of the arterial pressure sensitivity curve in the Hyp group did not differ from Cont.(ABSTRACT TRUNCATED AT 250 WORDS)

213: Acute ascending aorta occlusion leads to decreased cerebral perfusion pressure in a fetal sheep

2013 ◽  
Vol 208 (1) ◽  
pp. S99
Author(s):  
Heikki Huhta ◽  
Juha Räsänen ◽  
Juulia Junno ◽  
Mervi Haapsamo ◽  
Tiina Erkinaro ◽  
...  
Keyword(s):  
Cerebral Perfusion Pressure ◽  
Cerebral Perfusion ◽  
Perfusion Pressure ◽  
Ascending Aorta ◽  
Fetal Sheep

Cardiac function during long-term hypoxemia in fetal sheep

1989 ◽  
Vol 257 (2) ◽  
pp. H581-H589 ◽  
Author(s):  
J. G. Alonso ◽  
T. Okai ◽  
L. D. Longo ◽  
R. D. Gilbert
Keyword(s):  
Arterial Pressure ◽  
Cardiac Function ◽  
Right Ventricular ◽  
Ventricular Function ◽  
Right Ventricular Function ◽  
Hemoglobin Concentration ◽  
Fetal Sheep ◽  
Intravascular Catheters ◽  
Arterial Po2

To examine right ventricular function during long-term hypoxemia, we instrumented 12 fetal sheep with intravascular catheters and an electromagnetic flow probe on the pulmonary artery. In six cases, hypoxemia was induced by infusing N2 gas into the maternal trachea for 2 wk. Maternal arterial PO2 was less than 60 Torr, and fetal arterial PO2 was reduced from approximately 26 to approximately 19 Torr. Six cases served as nonhypoxic controls. We studied fetal cardiac function by increasing either preload with a volume infusion of 5% (wt/vol) dextrose or afterload by administering methoxamine (alpha-adrenergic agonist). In hypoxic animals, right ventricular output (QRV) and stroke volume (SV) were not affected on the first 2 days but fell 30% on day 3. Fetal arterial pressure (Pfa) increased 20%, hemoglobin concentration increased approximately 30%, and fetal heart rate (FHR) showed minimal changes. Within 2 wk, QRV recovered to normal values, whereas ventricular sensitivity to arterial pressure was reduced. We observed no change in plasma concentration of "cardiac enzymes" or differences in fetal growth between groups. In conclusion, during prolonged hypoxemia, right ventricular function showed a triphasic response (primary maintenance, secondary depression, and subsequent recovery), achieving a new steady state 2 wk after the start of hypoxia, characterized by decreased sensitivity to afterload, associated with polycythemia and hypertension.

scholarly journals Foramen ovale blood flow and cardiac function after main pulmonary artery occlusion in fetal sheep

2019 ◽  
Vol 104 (2) ◽  
pp. 189-198 ◽  
Author(s):  
Juulia Lantto ◽  
Tiina Erkinaro ◽  
Mervi Haapsamo ◽  
Heikki Huhta ◽  
Hanna-Marja Voipio ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pulmonary Artery ◽  
Cardiac Function ◽  
Main Pulmonary Artery ◽  
Artery Occlusion ◽  
Foramen Ovale ◽  
Fetal Sheep

scholarly journals Feasibility of ventricular volumetry by cardiovascular MRI to assess cardiac function in the fetal sheep

2020 ◽  
Vol 598 (13) ◽  
pp. 2557-2573 ◽  
Author(s):  
Steven K. S. Cho ◽  
Jack R. T. Darby ◽  
Brahmdeep S. Saini ◽  
Mitchell C. Lock ◽  
Stacey L. Holman ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Cardiovascular Mri ◽  
Fetal Sheep ◽  
Ventricular Volumetry
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