scholarly journals Hyperglycaemia in pregnant rats causes sex-related vascular dysfunction in adult offspring: role of cyclooxygenase-2

2017 ◽  
Vol 102 (8) ◽  
pp. 1019-1036 ◽  
Author(s):  
Francine Gomes de Sá ◽  
Diego Barbosa de Queiroz ◽  
Fernanda Elizabethe Ramos-Alves ◽  
Juliana Santos-Rocha ◽  
Odair Alves da Silva ◽  
...  
Keyword(s):  
Vascular Dysfunction ◽  
Cyclooxygenase 2 ◽  
Adult Offspring ◽  
Pregnant Rats

scholarly journals α-Tocopherol Potentiates the Cervical Resistance Decreasing Effects of COX Inhibitors in Pregnant Rats: The Putative Role of Cyclooxygenase-2 Inhibition

2018 ◽  
Vol 368 (2) ◽  
pp. 292-298 ◽  
Author(s):  
Anna Kothencz ◽  
Judit Hajagos-Tóth ◽  
Kálmán F. Szűcs ◽  
Annamária Schaffer ◽  
Róbert Gáspár
Keyword(s):  
Cyclooxygenase 2 ◽  
Pregnant Rats ◽  
Cox Inhibitors ◽  
Putative Role ◽  
Cervical Resistance

scholarly journals Role of impaired endothelial cell Ca2+ signaling in uteroplacental vascular dysfunction during diabetic rat pregnancy

2013 ◽  
Vol 304 (7) ◽  
pp. H935-H945 ◽  
Author(s):  
Natalia I. Gokina ◽  
Adrian D. Bonev ◽  
Alexander P. Gokin ◽  
Gabriela Goloman
Keyword(s):  
Endothelial Cell ◽  
Vascular Dysfunction ◽  
Maternal Blood ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Cellular Mechanisms ◽  
Citrate Buffer ◽  
Pregnant Rats ◽  
Intracellular Ca

Diabetes mellitus in pregnancy is associated with impaired endothelium-mediated dilatation of maternal arteries, although the underlying cellular mechanisms remain unknown. In this study, we hypothesized that diabetes during rat gestation attenuates agonist-induced uterine vasodilation through reduced endothelial cell (EC) Ca2+ elevations and impaired smooth muscle cell (SMC) hyperpolarization and SMC intracellular Ca2+ concentration ([Ca2+]i) responses. Diabetes was induced by an injection of streptozotocin to second-day pregnant rats and confirmed by the development of maternal hyperglycemia. Control rats were injected with a citrate buffer. Fura-2-based measurements of SMC [Ca2+]i or microelectrode recordings of SMC membrane potential were performed concurrently with dilator responses to ACh in uteroplacental arteries from control and diabetic pregnant rats. Basal levels of EC [Ca2+]i and ACh-induced EC [Ca2+]i elevations in pressurized vessels and small EC sheets were studied as well. Diabetes reduced ACh-induced vasodilation due to a markedly impaired EDHF-mediated response. Diminished vasodilation to ACh was associated with attenuated SMC hyperpolarization and [Ca2+]i responses. Basal levels of EC [Ca2+]i and ACh-induced EC [Ca2+]i elevations were significantly reduced by diabetes. In conclusion, these data demonstrate that reduced endothelium-mediated hyperpolarization contributes to attenuated uteroplacental vasodilation and SMC [Ca2+]i responses to ACh in diabetic pregnancy. Impaired endothelial Ca2+ signaling is in part responsible for endothelial dysfunction in the uterine resistance vasculature of diabetic rats. Pharmacological improvement of EC Ca2+ handling may provide an important strategy for the restoration of endothelial function and enhancement of maternal blood flow in human pregnancies complicated by diabetes.

Role of cyclooxygenase-2 in the development and treatment of oesophageal adenocarcinoma

2003 ◽  
Vol 38 (0) ◽  
pp. 87-93 ◽  
Author(s):  
C. J. Buskens ◽  
Ristimäki A. ◽  
G. J. A. Offerhaus ◽  
D. J. Richel ◽  
J. J. B. van Lanschot
Keyword(s):  
Cyclooxygenase 2 ◽  
Oesophageal Adenocarcinoma

Pancreatic morphology in pregnant rats exposed to DuP-697 - the irreversible, highly selective cyclooxygenase-2 inhibitor

2008 ◽  
Vol 63 (1) ◽  
pp. 96-101
Author(s):  
Franciszek Burdan ◽  
Justyna Szumiło ◽  
Jarosław Dudka ◽  
Agnieszka Korobowicz ◽  
Agnieszka Fronczek ◽  
...  
Keyword(s):  
Cyclooxygenase 2 ◽  
Pregnant Rats ◽  
Pancreatic Morphology

Role of Methylglyoxal in Diabetic Cardiovascular and Kidney Diseases: Insights from Basic Science for Application into Clinical Practice

2018 ◽  
Vol 24 (26) ◽  
pp. 3072-3083 ◽  
Author(s):  
Sowndramalingam Sankaralingam ◽  
Angham Ibrahim ◽  
MD Mizanur Rahman ◽  
Ali H. Eid ◽  
Shankar Munusamy
Keyword(s):  
Therapeutic Strategy ◽  
Kidney Diseases ◽  
Vascular Dysfunction ◽  
Dicarbonyl Compound ◽  
Renal Complications ◽  
Lysine Residues ◽  
Patients With Diabetes ◽  
Prevalence Of Diabetes Mellitus

Background: The incidence and prevalence of diabetes mellitus are increasing globally at alarming rates. Cardiovascular and renal complications are the major cause of morbidity and mortality in patients with diabetes. Methylglyoxal (MG) - a highly reactive dicarbonyl compound – is increased in patients with diabetes and has been implicated to play a detrimental role in the etiology of cardiovascular and renal complications. Derived from glucose, MG binds to arginine and lysine residues in proteins, and the resultant end products serve as surrogate markers of MG generation in vivo. Under normal conditions, MG is detoxified by the enzyme glyoxalase 1 (Glo1), using reduced glutathione as a co-factor. Elevated levels of MG is known to cause endothelial and vascular dysfunction, oxidative stress and atherosclerosis; all of which are risk factors for cardiovascular diseases. Moreover, MG has also been shown to cause pathologic structural alterations and impair kidney function. Conversely, MG scavengers (such as N-acetylcysteine, aminoguanidine or metformin) or Nrf2/Glo1 activators (such as trans-resveratrol / hesperetin) are shown to be useful in preventing MG-induced cardiovascular and renal complications in diabetes. However, clinical evidence supporting the MG lowering properties of these agents are limited and hence, need further investigation. Conclusion: Reducing MG levels directly using scavengers or indirectly via activation of Nrf2/Glo1 may serve as a novel and potent therapeutic strategy to counter the deleterious effects of MG in diabetic complications.

Recent Progress in the Therapeutic Role of Serelaxin in Vascular Dysfunction

2018 ◽  
Vol 19 (11) ◽  
pp. 1079-1087 ◽  
Author(s):  
Ghulam Murtaza ◽  
Adeel Siddiqui ◽  
Izhar Hussain
Keyword(s):  
Recent Progress ◽  
Vascular Dysfunction ◽  
Therapeutic Role

The Role of Cyclooxygenase-2 in Lumbar Disc Herniation

Spine ◽  
2002 ◽  
Vol 27 (22) ◽  
pp. 2477-2483 ◽  
Author(s):  
Hiroshi Miyamoto ◽  
Ryuichi Saura ◽  
Minoru Doita ◽  
Masahiro Kurosaka ◽  
Kosaku Mizuno
Keyword(s):  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Lumbar Disc ◽  
Cyclooxygenase 2

scholarly journals A systems biology model of junctional localization and downstream signaling of the Ang–Tie signaling pathway

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yu Zhang ◽  
Christopher D. Kontos ◽  
Brian H. Annex ◽  
Aleksander S. Popel
Keyword(s):  
Signaling Pathway ◽  
Molecular Mechanisms ◽  
Vascular Dysfunction ◽  
Reaction Network ◽  
Vascular Growth ◽  
Downstream Signaling ◽  
Signaling Axis ◽  
Agonistic Activity ◽  
Molecular Regulatory Mechanisms

AbstractThe Ang–Tie signaling pathway is an important vascular signaling pathway regulating vascular growth and stability. Dysregulation in the pathway is associated with vascular dysfunction and numerous diseases that involve abnormal vascular permeability and endothelial cell inflammation. The understanding of the molecular mechanisms of the Ang–Tie pathway has been limited due to the complex reaction network formed by the ligands, receptors, and molecular regulatory mechanisms. In this study, we developed a mechanistic computational model of the Ang–Tie signaling pathway validated against experimental data. The model captures and reproduces the experimentally observed junctional localization and downstream signaling of the Ang–Tie signaling axis, as well as the time-dependent role of receptor Tie1. The model predicts that Tie1 modulates Tie2’s response to the context-dependent agonist Ang2 by junctional interactions. Furthermore, modulation of Tie1’s junctional localization, inhibition of Tie2 extracellular domain cleavage, and inhibition of VE-PTP are identified as potential molecular strategies for potentiating Ang2’s agonistic activity and rescuing Tie2 signaling in inflammatory endothelial cells.

scholarly journals Age-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels

2021 ◽  
Vol 22 (3) ◽  
pp. 1296
Author(s):  
Yue Ruan ◽  
Subao Jiang ◽  
Adrian Gericke
Keyword(s):  
Oxidative Stress ◽  
Macular Degeneration ◽  
Vascular Function ◽  
Vascular Dysfunction ◽  
Therapeutic Strategies ◽  
Vision Impairment ◽  
Age Related Macular Degeneration ◽  
Oxygen Species ◽  
Age Related

Age-related macular degeneration (AMD) is a common irreversible ocular disease characterized by vision impairment among older people. Many risk factors are related to AMD and interact with each other in its pathogenesis. Notably, oxidative stress and choroidal vascular dysfunction were suggested to be critically involved in AMD pathogenesis. In this review, we give an overview on the factors contributing to the pathophysiology of this multifactorial disease and discuss the role of reactive oxygen species and vascular function in more detail. Moreover, we give an overview on therapeutic strategies for patients suffering from AMD.

Sign in / Sign up

Export Citation Format

Share Document