scholarly journals Butyrate stimulates adipose lipolysis and mitochondrial oxidative phosphorylation through histone hyperacetylation-associated β3-adrenergic receptor activation in high-fat diet-induced obese mice

2017 ◽  
Vol 102 (2) ◽  
pp. 273-281 ◽  
Author(s):  
Yimin Jia ◽  
Jian Hong ◽  
Huifang Li ◽  
Yun Hu ◽  
Longfei Jia ◽  
...  
Keyword(s):  
Oxidative Phosphorylation ◽  
High Fat Diet ◽  
Adrenergic Receptor ◽  
Receptor Activation ◽  
Obese Mice ◽  
Mitochondrial Oxidative Phosphorylation ◽  
High Fat ◽  
Histone Hyperacetylation

scholarly journals Effect of Adrenergic Agonists on High-Fat Diet-Induced Hepatic Steatosis in Mice

2020 ◽  
Vol 21 (24) ◽  
pp. 9392
Author(s):  
Yukiomi Nakade ◽  
Rena Kitano ◽  
Taeko Yamauchi ◽  
Satoshi Kimoto ◽  
Kazumasa Sakamoto ◽  
...  
Keyword(s):  
Nervous System ◽  
Hepatic Steatosis ◽  
High Fat Diet ◽  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Receptor Activation ◽  
Mrna Levels ◽  
High Fat ◽  
Adrenergic Receptor Agonist ◽  
Stimulation Of

The autonomic nervous system, consisting of sympathetic and parasympathetic branches, plays an important role in regulating metabolic homeostasis. The sympathetic nervous system (SNS) regulates hepatic lipid metabolism by regulating adrenergic receptor activation, resulting in the stimulation of hepatic very-low-density lipoprotein-triglyceride (TG) production in vivo. However, only a few studies on the relationship between SNS and hepatic steatosis have been reported. Here, we investigate the effect of adrenergic receptor agonists on hepatic steatosis in mice fed a high-fat diet (HFD). The α-adrenergic receptor agonist phenylephrine (10 mg/kg/d) or the β-adrenergic receptor agonist isoproterenol (30 mg/kg/d) was coadministered with HFD to male mice. After five weeks, hepatic steatosis, TG levels, and hepatic fat metabolism-related biomarkers were examined. HFD treatment induced hepatic steatosis, and cotreatment with phenylephrine, but not isoproterenol, attenuated this effect. Phenylephrine administration upregulated the mRNA levels of hepatic peroxisome proliferator-activated receptor alpha and its target genes (such as carnitine palmitoyltransferase 1) and increased hepatic β-hydroxybutyrate levels. Additionally, phenylephrine treatment increased the expression of the autophagosomal marker LC3-II but decreased that of p62, which is selectively degraded during autophagy. These results indicate that phenylephrine inhibits hepatic steatosis through stimulation of β-oxidation and autophagy in the liver.

scholarly journals Ginkgolide B lowers body weight and ameliorates hepatic steatosis in high-fat diet-induced obese mice correlated with pregnane X receptor activation

RSC Advances ◽  
2017 ◽  
Vol 7 (60) ◽  
pp. 37858-37866 ◽  
Author(s):  
Lingling Luo ◽  
Yin Li ◽  
Dongshan Wang ◽  
Yuanyuan Zhao ◽  
Yahui Wang ◽  
...  
Keyword(s):  
Body Weight ◽  
Hepatic Steatosis ◽  
High Fat Diet ◽  
Pregnane X Receptor ◽  
Receptor Activation ◽  
Ginkgolide B ◽  
Obese Mice ◽  
High Fat

Ginkgolide B (GB) is a natural occurring terpene lactone and a selective agonistic ligand of hPXR.

scholarly journals A High-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle

Diabetes ◽  
2005 ◽  
Vol 54 (7) ◽  
pp. 1926-1933 ◽  
Author(s):  
L. M. Sparks ◽  
H. Xie ◽  
R. A. Koza ◽  
R. Mynatt ◽  
M. W. Hulver ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Oxidative Phosphorylation ◽  
High Fat Diet ◽  
Mitochondrial Oxidative Phosphorylation ◽  
High Fat

Topical Application of Capsaicin Reduces Visceral Adipose Fat by Affecting Adipokine Levels in High-Fat Diet-Induced Obese Mice

Obesity ◽  
2012 ◽  
Author(s):  
Gong-Rak Lee ◽  
Mi Kyung Shin ◽  
Dong-Joon Yoon ◽  
Ah-Ram Kim ◽  
Rina Yu ◽  
...  
Keyword(s):  
Topical Application ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Visceral Adipose

Proteomic analysis of the anti-obesity effect of Taeumjowui-Tang in high fat diet-induced obese mice

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
E Changkyun Park ◽  
SY Lee ◽  
SH Yun ◽  
WY Kim ◽  
Y Yi ◽  
...  
Keyword(s):  
Proteomic Analysis ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat

Inhibition of Adipose Tissue Angiogenesis Prevents Rebound Weight Regain after Calorie Restriction Independent of Hypothalamic Melanocortin System in Obese Mice Fed a High-Fat Diet

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 287-LB
Author(s):  
HYE-JIN LEE ◽  
MUN-GYU SONG ◽  
NA-HEE HA ◽  
BO-YEONG JIN ◽  
SANG-HYUN CHOI ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Calorie Restriction ◽  
High Fat Diet ◽  
Weight Regain ◽  
Obese Mice ◽  
High Fat ◽  
Melanocortin System
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