scholarly journals Stress‐sensitive arterial hypertension, haemodynamic changes and brain metabolites in hypertensive ISIAH rats: MRI investigation

2017 ◽  
Vol 102 (5) ◽  
pp. 523-532 ◽  
Author(s):  
A. A. Seryapina ◽  
O. B. Shevelev ◽  
M. P. Moshkin ◽  
A. L. Markel ◽  
A. E. Akulov
Keyword(s):  
Arterial Hypertension ◽  
Brain Metabolites ◽  
Isiah Rats ◽  
Haemodynamic Changes ◽  
Hypertensive Isiah Rats

scholarly journals Renin-angiotensin system gene expression in the kidney and in the heart in hypertensive ISIAH rats

2011 ◽  
Vol 57 (4) ◽  
pp. 410-419 ◽  
Author(s):  
L.A. Fedoseeva ◽  
M.A. Ryazanova ◽  
E.V. Antonov ◽  
G.M. Dymshiz ◽  
A.L. Markel
Keyword(s):  
Arterial Hypertension ◽  
Mrna Expression ◽  
Renin Angiotensin System ◽  
Plasma Sodium ◽  
Isiah Rats ◽  
Ras Gene ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Ras Genes ◽  
Hypertensive Isiah Rats

The content of mRNA of renin-angiotensin system (RAS) genes in the kidney and heart of hypertensive ISIAH and normotensive WAG rats was measured by the real-time PCR. Statistically significant decrease of RAS gene mRNA was registered in the kidney of ISIAH rats, including Ren (by 45%), Аce (43%), АТ1А (34%), СОХ-2 (50%). In the myocardium АТ1А mRNA expression decreased by 28% while Ace mRNA expression increased by 80%. These results demonstrate the reduction of renal RAS basal activity in the hypertensive ISIAH rats, and this allows us to consider the ISIAH rat, as a low-renin hypertensive strain.In support of this viewpoint, in the ISIAH rats, a two-fold increase in the connective tissue sodium concentration as well as statistically significant plasma sodium increase (from 136±0,25 μmol/l in WAG to 139±0,3 μmol/l in the ISIAH rats) were found. Our conclusion backed by a tendency of the ISIAH plasma aldosterone level decrease giving in sum a classical picture of a low-renin hypertensive state in the ISIAH rats.It was suggested that the formation of low-renin arterial hypertension in the ISIAH rats may depend on changes in kidney ion channels function. In addition, renal NO system alterations could be also involved in the pathogenesis of arterial hypertension in the ISIAH rats.

Sequencing of the 5′ region of the Lngfr gene associated with stress-induced arterial hypertension in ISIAH rats

2008 ◽  
Vol 42 (1) ◽  
pp. 163-165 ◽  
Author(s):  
L. A. Fedoseeva ◽  
G. M. Dymshits ◽  
A. L. Markel
Keyword(s):  
Arterial Hypertension ◽  
Isiah Rats

scholarly journals Renin-angiotensin-aldosterone system in ISIAH rats with stressinduced arterial hypertension

2016 ◽  
Vol 20 (6) ◽  
pp. 954-958 ◽  
Author(s):  
A. D. Dubinina ◽  
E. V. Antonov ◽  
L. A. Fedoseeva ◽  
E. N. Pivovarova ◽  
A. L. Markel ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Isiah Rats ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin

Coupling of Lipoperoxidation Reactions with Changes in Arterial Blood Pressure in Hypertensive ISIAH Rats under Conditions of Chronic Stress

2018 ◽  
Vol 164 (6) ◽  
pp. 712-715 ◽  
Author(s):  
L. I. Kolesnikova ◽  
L. V. Rychkova ◽  
L. R. Kolesnikova ◽  
M. A. Darenskaya ◽  
L. V. Natyaganova ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Chronic Stress ◽  
Isiah Rats ◽  
Arterial Blood ◽  
Hypertensive Isiah Rats

The decreased expression of genes controlling the vascular tone in the kidneys of ISIAH rats with stress-induced arterial hypertension

2015 ◽  
Vol 5 (4) ◽  
pp. 340-347
Author(s):  
O. E. Redina ◽  
L. O. Klimov ◽  
N. I. Ershov ◽  
T. O. Abramova ◽  
L. N. Ivanova ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Vascular Tone ◽  
Isiah Rats ◽  
Expression Of Genes

Evaluation of Lipid Peroxidation—Antioxidant Defense System Depending on the Stage of Stress Reaction in Hypertensive ISIAH Rats

2019 ◽  
Vol 166 (5) ◽  
pp. 610-612
Author(s):  
L. I. Kolesnikova ◽  
L. R. Kolesnikova ◽  
M. A. Darenskaya ◽  
L. V. Natyaganova ◽  
L. A. Grebenkina ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Stress Reaction ◽  
Defense System ◽  
Isiah Rats ◽  
Hypertensive Isiah Rats

scholarly journals Neuroendocrine profiling in inherited stress-induced arterial hypertension rat strain with stress-sensitive arterial hypertension

2007 ◽  
Vol 195 (3) ◽  
pp. 439-450 ◽  
Author(s):  
A L Markel ◽  
O E Redina ◽  
M A Gilinsky ◽  
G M Dymshits ◽  
E V Kalashnikova ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Social Stress ◽  
Restraint Stress ◽  
Plasma Corticosterone ◽  
Isiah Rats ◽  
Handling Stress ◽  
Arterial Blood ◽  
Expression Of Genes ◽  
Genes Encoding ◽  
Rat Strain

The functions of the hypothalamic adrenal cortical and sympathetic adrenal medullary systems were studied in rats with inherited stress-induced arterial hypertension (ISIAH strain). A characteristic feature of the ISIAH strain is an increase in arterial blood pressure measured both under basal conditions and after restraint stress in particular. In the control ISIAH rats, the basal plasma ACTH concentration was slightly lower than that in the normotensive Wistar albino Glaxo (WAG) rats, and no differences were found in plasma corticosterone. However, the 0.5-h restraint stress produced higher activation of the adrenal cortex in the ISIAH rats. Gluco- and mineralocorticoid responses to the blood volume reduction stresses and ACTH and corticosterone responses to social stress were stronger in the ISIAH than in the control WAG rats. An increase in epinephrine content in adrenals in the basal state and enhanced response of the sympathetic adrenal medullary system to handling stress were observed in the ISIAH rats. Restraint stress produced significantly higher expression of genes encoding corticotropin-releasing hormone-mRNA in hypothalamus and proopiomelanocortin-mRNA in pituitary in the ISIAH than in the WAG rats. Restraint stress produced a decrease in glucocorticoid receptor (GR) gene expression (GR-mRNA) in hippocampus in the ISIAH, but not in the WAG rats. A persistent increase in tyrosine hydroxylase-mRNA in adrenals of the ISIAH rats was found. It is concluded that the ISIAH rat strain is an appropriate model of stress-sensitive hypertension with the predominant involvement of the hypothalamic adrenal cortical and sympathetic adrenal medullary systems in its pathogenesis.

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