EFFECTS OF 900 MHZ RADIOFREQUENCY RADIATION ON THE RATS’ LIVER

2016 ◽  
Vol 78 (6-7) ◽  
Author(s):  
Usikalu M. R. ◽  
Rotimi S. O. ◽  
Achuka J. A.
Keyword(s):  
Liver Function ◽  
Mobile Phone ◽  
Liver Function Tests ◽  
Male Rats ◽  
Whole Body ◽  
Control Group ◽  
Experimental Conditions ◽  
Test Kit ◽  
Group B ◽  
Mobile Phone Radiation

The goal of the study is to evaluate the liver function tests and histological alterations of the rats liver cells after exposure to mobile phone radiation. To perform the liver function test Aspartate transaminase (AST) U.V kinetic test kit produced by CYPRESS DIAGNOSTICS and spectrophotometer was used. Wistar rats (male, 5 week old, approximate body weight 30-40 g) (N = 12) were exposed to 900 MHz mobile phone radiation of Global System Mobile signal modulation (GSM), whole body average specific absorption rate SAR of 1.090W/kg. Twelve (12) male rats were used for the study divided into 3 groups of 4 rats each. Group B and Group C were exposed to 4 hours/day and 8 hours/day mobile phone radiation during calling mode for 2 months respectively while Group A served as control.  There was significant reduction in total  protein, globulin,  while there was significantly increased in Glutamate Oxalacetate Transaminase (GOT), Alkaline Phosphatase (ALP), Albumin, total bilirubin in the rats (Group B and C) exposed to mobile phone radiation when compared to the control group but there was no histological alteration in the arrangement of cells in both control and exposed group. The results of this study suggest that, under the experimental conditions applied, repeated 900 MHz irradiation could modify liver functions.

Effect of electromagnetic waves from mobile phone on immune status of male rats: possible protective role of vitamin D

2017 ◽  
Vol 95 (2) ◽  
pp. 151-156 ◽  
Author(s):  
Ola Ahmed El-Gohary ◽  
Mona Abdel-Azeem Said
Keyword(s):  
Vitamin D ◽  
Immune System ◽  
Mobile Phone ◽  
Protective Role ◽  
Vitamin D Supplementation ◽  
Male Rats ◽  
Control Group ◽  
Group I ◽  
Mobile Phone Radiation

There are considerable public concerns about the relationship between mobile phone radiation and human health. The present study assesses the effect of electromagnetic field (EMF) emitted from a mobile phone on the immune system in rats and the possible protective role of vitamin D. Rats were randomly divided into six groups: Group I: control group; Group II: received vitamin D (1000 IU/kg/day) orally; Group III: exposed to EMF 1 h/day; Group IV: exposed to EMF 2 h/day; Group V: exposed to EMF 1 h/day and received vitamin D (1000 IU/kg/day); Group VI: exposed to EMF 2 h/day and received vitamin D (1000 IU/kg/day). After 30 days of exposure time, 1 h/day EMF exposure resulted in significant decrease in immunoglobulin levels (IgA, IgE, IgM, and IgG); total leukocyte, lymphocyte, eosinophil and basophil counts; and a significant increase in neutrophil and monocyte counts. These changes were more increased in the group exposed to 2 h/day EMF. Vitamin D supplementation in EMF-exposed rats reversed these results when compared with EMF-exposed groups. In contrast, 7, 14, and 21 days of EMF exposure produced nonsignificant differences in these parameters among all experimental groups. We concluded that exposure to mobile phone radiation compromises the immune system of rats, and vitamin D appears to have a protective effect.

scholarly journals Evaluation of radioprotective effect of carnosine (beta- alanyl-1- histidine) on the wound healing in rats

2005 ◽  
Vol 13 (3) ◽  
pp. 253-258 ◽  
Author(s):  
Rosana Aramaki Tanaka ◽  
Flávia Maria de Moraes Ramos ◽  
Solange Maria de Almeida ◽  
Mário Roberto Vizioli ◽  
Frab Norberto Bóscolo
Keyword(s):  
Wound Healing ◽  
Surgical Procedure ◽  
Tissue Repair ◽  
Radioprotective Effect ◽  
Male Rats ◽  
Whole Body ◽  
Control Group ◽  
Experimental Conditions ◽  
Anterior Dorsal ◽  
Radioprotective Substance

The purpose of this study was to evaluate the radioprotective effect of carnosine (beta- alanyl-1-histidine) on the wound healing in rats. Therefore, 48 male rats were submitted to a surgical procedure to perform a rectangular wound in the anterior-dorsal region. The animals were divided into 4 experimental groups randomly chosen: control; irradiated; carnosine irradiated and carnosine group. The irradiated and carnosine irradiated group were exposed to a dose (6Gy) of gamma irradiation, in the whole body, 72 hours after surgery. The carnosine and carnosine irradiated groups, in addition to the surgical procedure and the irradiation, received two doses of carnosine aqueous solution, the first one being injected 48 hours after surgery, and the second one 1 hour and 30 minutes before irradiation. The tissue repair of the 4 groups was evaluated at 4, 7, 14, and 21 days after inflicting the wound, by morphological, histochemical and histophysical methods. At all examined periods, it could be observed that the animals from the carnosine irradiated group presented a better developed granulation tissue than the irradiated group and closely similar to that of the control group. Thus, under the experimental conditions used, it was possible to conclude that carnosine is an effective radioprotective substance.

Acute and subchronic co-administrations to cadmium, diazinon and selenium induce apparent osteoporotic symptoms in adult male rats

Biologia ◽  
2014 ◽  
Vol 69 (10) ◽  
Author(s):  
Hana Ďúranová ◽  
Monika Martiniaková ◽  
Ivana Boboňová ◽  
Radoslav Omelka ◽  
Robert Stawarz ◽  
...  
Keyword(s):  
Adult Male ◽  
Osteoporotic Fractures ◽  
Bone Diseases ◽  
Male Rats ◽  
Control Group ◽  
Femoral Bone ◽  
Negative Effects ◽  
Young Males ◽  
Male Wistar Rats ◽  
Group B

AbstractCadmium (Cd) and diazinon (DZN) are known to be environmental risk factors for various bone diseases including osteoporosis. Selenium (Se), an essential constituent of many antioxidant enzymes, has in higher concentrations negative effects on the bone. The present study was aimed to investigate possible changes in femoral bone of adult male rats after their acute and subchronic exposures to Cd, DZN and Se. A total of 30 male Wistar rats were randomized into three experimental groups. The rats in the group A (4-months-old) were injected intraperitoneally with a mixture of 2 mg CdCl2 kg−1, 20 mg DZN kg−1 and 2 mg Na2SeO3 kg−1 body weight and killed 36 h after xenobiotics had been injected. In the group B, young males (1-month-old) were administered with a combination of 30 mg CdCl2 L−1, 40 mg DZN L−1 and 5 mg Na2SeO3 L−1 in their drinking water, for 90 days. Ten 4-months-old males without toxicant supplementation served as a control group (C). After treatment period, detailed histological analysis of femoral bone was performed in each group. Our results revealed apparent osteoporotic symptoms (resorption lacunae, osteoporotic fractures) in rats from groups A and B. Moreover, histomorphometrical evaluation showed reduced bone vascularization (constricted primary osteons’ vascular canals and Haversian canals) and weakness mechanical properties of bones (smaller size of the secondary osteons) in these rats in comparison with those of the control group. Our study demonstrates for the first time that acute and subchronic co-administrations to Cd, DZN and Se induce evident manifestation characteristics of osteoporosis in male rats.

scholarly journals EFFECT OF MOBILE PHONE RADIATION ON ADRENAL GLAND OF MALE ALBINO RATS

2020 ◽  
Vol 28 (1) ◽  
Author(s):  
Shalini Gupta ◽  
Shilpi Jain ◽  
Satyam Khare ◽  
Prateek Gautam
Keyword(s):  
Adrenal Gland ◽  
Mobile Phone ◽  
Radiation Exposure ◽  
Mobile Phones ◽  
Adrenal Glands ◽  
Cellular Level ◽  
Control Group ◽  
Albino Rats ◽  
Hormonal Changes ◽  
Mobile Phone Radiation

Introduction: The tremendous growth in telecommunication world has increased the number of mobile phone users to many folds. The benefits of cell phones are just half the picture. The other half may be a darker one. The main aim of this study is to observe the effect of electromagnetic radiation being emitted by mobile phones on adrenal gland microanatomy and the hormones released by the gland on male albino rats. Materials and methods: Forty-two male albino rats of Spargue-Dawley species were divided into two equal groups. The experimental group rats were exposed to mobile phone radiation operating at 900 MHz while the control group rats were not. At the end of every two months, seven rats were sacrificed to analyse histological and hormonal changes. Results: No changes were seen at the cellular level of the adrenal glands even after six months of radiation exposure. Hormonal assay showed a variation in the cortisol levels of the rats but the changes were within normal range. Conclusions: Lack of appreciable changes in the cellular morphology and hormonal levels even after six months of radiation exposure signify that the adrenal glands are not affected by exposure to mobile phones.

scholarly journals A Comparative Study on the Effects of Using Hydroalcoholic Extracts of Linum Usitatissimum and Rosa Damascena on Liver Function in Adult Male Rats

2020 ◽  
Vol 26 (1) ◽  
pp. 54-67
Author(s):  
Mohammad Mehdi Padam ◽  
◽  
Ameneh Khoshvaghti ◽  
Keyword(s):  
Liver Function ◽  
Total Protein ◽  
Linum Usitatissimum ◽  
Colorimetric Method ◽  
Serum Glucose ◽  
Male Rats ◽  
Control Group ◽  
Rosa Damascena ◽  
Glucose Levels ◽  
Significant Difference

Aims: Damage to liver tissue and its dysfunction is very important and if left untreated, it can cause serious problems and even death. In this study, we aimed to investigate the effects of the hydroalcoholic extracts of Linum usitatissimum and Rosa damascena on liver enzymes, total protein, bilirubin, albumin, and serum glucose levels. Materials and Methods: This is a non-randomized clinical trial conducted on 42 male rats divided into 6 groups; control group (group 1) received only sufficient water and food, groups 1 and 2 received 300 and 500 mg/ kgB.W Linum usitatissimum extract, groups 3 and 4 received 500 and 1000 mg/ kgB.W Rosa damascena, and group 6 received 100 mg/ kgB.W Linum usitatissimum plus 250 mg/ kgB.W Rosa damascena extracts intraperitoneally for 28 days. After the last injection, the rats were weighed and their blood samples were collected. The study parameters were measured using a colorimetric method by a spectrophotometer, and then were analyzed using ANOVA and Tukey’s test in SPSS V. 25 at a significance level of P<0.05. Findings: There was no significant difference between alanine aminotransferase, alkaline phosphatase, total and direct bilirubin levels in the control group in comparison with other groups (P>0.05). In the groups received Rosa damascena extract, there was a significant difference between total protein and albumin levels compared to the control group (P<0.05). Moreover, there was a significant difference between serum glucose and aspartate aminotransferase in the control group compared to other groups (P<0.05). Conclusion: Linum usitatissimum and Rosa damascena have no negative effect on the liver function. The probability of diarrhea occurrence and the possible effects on the total protein and serum albumin after using Rosa damascena, and the effects of different doses of Linum usitatissimum on the glucose levels should be taken into account.

Phase I and pharmacokinetic trial of paclitaxel in patients with hepatic dysfunction: Cancer and Leukemia Group B 9264.

1998 ◽  
Vol 16 (5) ◽  
pp. 1811-1819 ◽  
Author(s):  
A P Venook ◽  
M J Egorin ◽  
G L Rosner ◽  
T D Brown ◽  
T M Jahan ◽  
...  
Keyword(s):  
Liver Function ◽  
Bilirubin Level ◽  
Liver Function Tests ◽  
Maximum Tolerated Dose ◽  
Abnormal Liver Function ◽  
Pharmacokinetic Data ◽  
Infusion Schedule ◽  
Group B ◽  
The Relationship ◽  
Leukemia Group

PURPOSE To characterize the maximum-tolerated dose, dose-limiting toxicities (DLTs), and pharmacokinetics of paclitaxel in patients with abnormal liver function. PATIENTS AND METHODS Adults with tumors appropriate for paclitaxel therapy who had abnormal liver function tests were eligible. Patients were assigned to one of three treatment cohorts: I, AST level twofold normal and bilirubin level less than 1.5 mg/dL; II, bilirubin level 1.6 to 3.0 mg/dL; and III, bilirubin level greater than 3.0 mg/dL. Doses were explored in at least three patients within each cohort. Although designed to assess a 24-hour infusion schedule, the trial was extended to also assess a 3-hour regimen. Pharmacokinetics were to be studied in all patients. RESULTS Eighty-one patients were assessable for toxicity. Patients with bilirubin levels greater than 1.5 mg/dL had substantial toxicity at all doses explored, whereas the toxicity for patients with elevated AST levels occurred at doses that ranged from 50 to 175 mg/m2 administered over 24 hours. In most patients, the DLT was myelosuppression. The pharmacokinetic data were insufficient to adequately evaluate the relationship between pharmacokinetics and toxicity in patients who received 24-hour infusions but provided evidence of a longer exposure to paclitaxel than anticipated for the doses used in this study in the 3-hour infusion group. CONCLUSION If paclitaxel is used for patients with elevated levels of AST or bilirubin, dose reductions are necessary, and an increase in toxicity can be anticipated. The increased myelosuppression observed is at least partially because of altered paclitaxel pharmacokinetics in such patients.

Fisher Discrimination of Metabolic Changes in Rats Treated with Aspirin and Ibuprofen

Pharmacology ◽  
2017 ◽  
Vol 100 (3-4) ◽  
pp. 194-200 ◽  
Author(s):  
Jing Zhang ◽  
Huanchun Song ◽  
Shuying Jiang ◽  
Zhibin Chen ◽  
Shuhua Tong ◽  
...  
Keyword(s):  
Liver Function ◽  
Liver Function Tests ◽  
Gas Chromatography Mass Spectrometry ◽  
Control Group ◽  
Intragastric Administration ◽  
Acetoacetic Acid ◽  
Toxic Reaction ◽  
Function Tests ◽  
Metabolomic Data ◽  
Aspirin Group

Background: Aspirin and ibuprofen are the most frequently prescribed non-steroidal anti-inflammatory drugs in the world. However, both are associated with a variety of toxicities. We applied serum metabonomics and Fisher discrimination for the early diagnosis of its toxic reaction in order to help diagnose these toxicities. Methods: A total of 45 rats were randomly divided into Control group, Aspirin group, and Ibuprofen groups. The experiment groups were given intragastric aspirin (15 mg/kg) or ibuprofen (15 mg/kg) for 3 weeks. Liver function tests were performed and blood metabonomics were analyzed by gas chromatography-mass spectrometry. Results: The most important compounds altered were trihydroxybutyric acid and l-alanine in the aspirin group, and acetoacetic acid, l-alanine, and trihydroxybutyric acid in the ibuprofen group. With respect to metabolic profiles, all 3 groups were completely distinct from one another. Fisher discrimination showed that 91.1% of the original grouped cases were correctly classified by the third week. However, only 55.6% of liver function tests were able to classify grouped cases correctly. Conclusion: Trihydroxybutyric acid, l-alanine, and acetoacetic acid were the most significant indicators of altered serum metabolites following intragastric administration of aspirin and ibuprofen in rates. These metabolomic data may be used for classification of aspirin and ibuprofen toxicity.

Electrolyte composition changes of chronically K-depleted rats after K loading

1987 ◽  
Vol 63 (2) ◽  
pp. 765-769 ◽  
Author(s):  
M. Sadre ◽  
H. P. Sheng ◽  
M. Fiorotto ◽  
B. L. Nichols
Keyword(s):  
Water Retention ◽  
Male Rats ◽  
Whole Body ◽  
Control Group ◽  
Elevated Plasma ◽  
Deficient Diet ◽  
Dose Control ◽  
And Control ◽  
Composition Changes ◽  
K Depletion

The responses of whole body, skeletal muscle, and plasma to oral K loading were studied in K-depleted male rats. Potassium depletion was induced by feeding the rats a K-deficient diet for 4 wk and injecting deoxycorticosterone acetate during the first week. After 4 wk, the rats were growth retarded and hypokalemic (1.9 mmol/l plasma) and had low whole-body and muscle K content, 188 +/- 27 and 276 +/- 19 mmol/kg fat-free dried tissue (FFDT), respectively, compared with 296 +/- 10 and 454 +/- 13 mmol/kg FFDT for the control group. Sodium and water retention also occurred in the K-deficient group. After K depletion, the rats were divided into four groups and received either 0, 1, 2, or 3 intragastric doses of 10 mmol KCl/kg at 8-h intervals. The rats were killed 8 h after the last dose. Control rats were treated similarly. K-depleted and control rats responded differently to K loading. In the normal rats, plasma K remained at 5.0 +/- 0.5 mmol/l, muscle K increased to 502 +/- 24 mmol/kg, and muscle K/N ratio increased from 3.0 to 3.4 mmol/g. In the K-depleted rats, plasma K increased to 7.2 +/- 0.7 mmol/l, muscle K increased to 453 +/- 50 mmol/kg, and muscle K/N ratio increased from 1.8 to 3.1 mmol/g. These data indicate that the capacity of the muscles to accumulate K was impaired after severe K depletion and caused elevated plasma K levels when repletion was complete.

scholarly journals Study On Harmful Effects Of Opium On Liver And Lungs In Chronic Opium Addicts Of Western Rajasthan

1970 ◽  
Vol 6 (2) ◽  
pp. 122-126 ◽  
Author(s):  
M Pawan ◽  
Raghuveer Choudhary ◽  
Ranjana Mathur ◽  
MR Choudhary ◽  
M Kamla
Keyword(s):  
Alkaline Phosphatase ◽  
Lung Function ◽  
Adult Male ◽  
Rural Areas ◽  
Liver Function Tests ◽  
Control Group ◽  
Male Population ◽  
Function Tests ◽  
Group A ◽  
Group B

Background: Today opium dependence is widely prevalent in certain states of India, especially Rajasthan, Punjab, Haryana, Madhya Pradesh (MP) etc. In rural areas of western Rajasthan crude opium is consumed with a social acceptance by a notable proportion (8.0%) of adult male population. Later on they become addicted to it. Objective: to observe the changes in some liver and lung function parameters in opium addicted subjects of Barmer city of Western Rajasthan. Methods: The present study was conducted in district hospital of Barmer, Rajasthan. Total fifty (50) adult male subjects with age ranged from 30 to 50 years were participated in this study. Among them 25 were opium addicted and were considered as study group (Group B) and another 25 apparently healthy adult male of same age group were designated as control group (Group A). Opium addicts were consuming about 5–11 gm/day opium for >2 years. Then liver function tests were evaluated by estimating serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase and lung function tests by measuring FVC, FEV1 , FEV1/FVC% , PEF, FEF 25-75% of both the groups. Results: In this study AST, ALT and alkaline phosphatase levels were found significantly (p<.05) higher in group B as compared to those of group A. Again, FVC, FEV1, FEV1/ FVC were significantly (p<.05) lower in group B as compared to those of group A. PEF (L/sec) and FEF 25-75% were also significantly (p<0.001) lower in group B as compared to those of group A. Conclusion: it is concluded that chronic long term use of opium, increases the risk of hepatic and pulmonary damage. DOI: http://dx.doi.org/10.3329/jbsp.v6i2.9762 JBSP 2011 6(2): 122-126

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