EXTRACTION AND EVALUATION OF ANTI INFLAMMATORY ACTIVITY OF SPATHIPHYLLUM CANNIFOLIUM

2015 ◽  
Vol 77 (24) ◽  
Author(s):  
Raha Ahmad Raus ◽  
Norhayati Abdullah ◽  
Nurul Fakhriah Ismail ◽  
Munira Shahbuddin
Keyword(s):  
Optimum Condition ◽  
Bioactive Compounds ◽  
Bioactive Compound ◽  
Inflammatory Activity ◽  
Chloroform Fraction ◽  
Landscape Plant ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Face Centered ◽  
Central Composite

Sphathiphyllum cannifolium is abundantly planted in Malaysia as a landscape plant. However, this plant also has medical benefit to human as it was previously found to possess anti-bacteria and anti-cancer activities. In the present study, the plant was evaluated for its anti inflammatory activity and the optimum condition for the extraction of bioactive compounds with anti inflammatory activity was determined. Semi purification of the compounds possessing anti inflammatory activity was conducted as well. To extract the bioactive compound, sonication with methanol as a solvent extraction was carried out. Face-Centered Central Composite Design (FCCCD) and Response Surface Methodology (RSM) were used to design and identify the optimum condition to extract the compound, respectively. The results showed that the plant was positive for the anti inflammatory activity with IC50 6.3 µg/ml. Sonication for 60 min at 40°C using medium frequency was the optimum condition to carry out the extraction for bioactive compounds. After semi purification of the initial crude extract by solvent partitioning, chloroform fraction was found to be positive for anti inflammatory activity. In conclusion, this study suggested that S. cannifolium possess anti inflammatory activity and should be further analyzed to identify the specific compounds that responsible for this activity.   

An Overview of Novel Bioactive Compounds with Potent Anti-Inflammatory Activity via Dual COX-2 and 5-LOX Enzyme Inhibition

2021 ◽  
Vol 18 ◽  
Author(s):  
Roopal Mittal ◽  
Shailesh Sharma ◽  
Ajay Singh Kushwah
Keyword(s):  
Bioactive Compounds ◽  
Enzyme Inhibitors ◽  
World Health Organisation ◽  
The Body ◽  
Inflammatory Activity ◽  
World Health ◽  
Quality Data ◽  
The World ◽  
Cox 2 ◽  
Anti Inflammatory

Background: Inflammation is the earliest body defence mechanism in which the immune system recognises and counters the antigens and aids in healing the disease. The World Health Organisation suggests that inflammation is one of the greatest causes of death in the world. Inflammation could be acute or chronic due to the release of inflammatory mediators i.e. prostaglandins, leukotrienes due to mitogens, antigens or cytokines found in the body. Methods: Bibliographic database using pub med cites for peer-reviewed research articles with titles containing dual COX-2 and 5-LOX enzyme inhibitors, heterocyclic moieties, with AND Boolean operator's terms since last ten years of literature work. The quality papers containing the natural or synthetic lead compounds were extracted; the detailed study and conceptual framework attracted its attention. Results: Out of 127 research and review articles evaluated, 54 articles were cited to provide high quality data regarding pharmacoactive molecules having anti-inflammatory activity via dual COX-2/5-LOX inhibition. In addition, highlighting their in silico and experimental wet laboratory studies in increasing order over the past decade with the best illustration of dual enzyme inhibitory activity. Conclusion: This review gathered details of isolated bioactive compounds such as pyrazole, coumaperine, indoles, phenanthrene derivatives that have been significantly reported for anti-inflammatory activities.

Marine Bioactive Compounds: Stereospecific Anti-Inflammatory Activity of Natural and Synthetic Cordiachromene A

1992 ◽  
Vol 32 (1) ◽  
pp. 37-40 ◽  
Author(s):  
Abdel Fattah Benslimane ◽  
Yves François Pouchus ◽  
Jean-François Verbist ◽  
Jean-Yves Petit ◽  
En Nassiri Khettab ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Natural And Synthetic

Synthesis, anti-cancer and anti-inflammatory activity of novel 2-substituted isoflavenes

2014 ◽  
Vol 22 (19) ◽  
pp. 5182-5193 ◽  
Author(s):  
Eleanor Eiffe ◽  
Eddy Pasquier ◽  
Maria Kavallaris ◽  
Cristan Herbert ◽  
David StC Black ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Anti Cancer ◽  
Anti Inflammatory

scholarly journals Sargassum Seaweed as a Source of Anti-Inflammatory Substances and the Potential Insight of the Tropical Species: A Review

Marine Drugs ◽  
2019 ◽  
Vol 17 (10) ◽  
pp. 590 ◽  
Author(s):  
Saraswati ◽  
Puspo Edi Giriwono ◽  
Diah Iskandriati ◽  
Chin Ping Tan ◽  
Nuri Andarwulan
Keyword(s):  
Bioactive Compounds ◽  
Optimal Growth ◽  
The Body ◽  
Inflammatory Activity ◽  
Sulfated Polysaccharides ◽  
Tropical Species ◽  
Tropical Region ◽  
Inflammatory Conditions ◽  
Microbial Infections ◽  
Anti Inflammatory

Sargassum is recognized both empirically and scientifically as a potential anti-inflammatory agent. Inflammation is an important response in the body that helps to overcome various challenges to body homeostasis such as microbial infections, tissue stress, and certain injuries. Excessive and uncontrolled inflammatory conditions can affect the pathogenesis of various diseases. This review aims to explore the potential of Sargassum’s anti-inflammatory activity, not only in crude extracts but also in sulfated polysaccharides and purified compounds. The tropical region has a promising availability of Sargassum biomass because its climate allows for the optimal growth of seaweed throughout the year. This is important for its commercial utilization as functional ingredients for both food and non-food applications. To the best of our knowledge, studies related to Sargassum’s anti-inflammatory activity are still dominated by subtropical species. Studies on tropical Sargassum are mainly focused on the polysaccharides group, though there are some other potentially bioactive compounds such as polyphenols, terpenoids, fucoxanthin, fatty acids and their derivatives, typical polar lipids, and other groups. Information on the modulation mechanism of Sargassum’s bioactive compounds on the inflammatory response is also discussed here, but specific mechanisms related to the interaction between bioactive compounds and targets in cells still need to be further studied.

Anti-inflammatory activity of cinnamon (C. zeylanicum and C. cassia) extracts – identification of E-cinnamaldehyde and o-methoxy cinnamaldehyde as the most potent bioactive compounds

2015 ◽  
Vol 6 (3) ◽  
pp. 910-919 ◽  
Author(s):  
Dhanushka Gunawardena ◽  
Niloo Karunaweera ◽  
Samiuela Lee ◽  
Frank van Der Kooy ◽  
David G. Harman ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Inflammatory Activity ◽  
Anti Inflammatory

The main inflammatory compounds in cinnamon are E-cinnamaldehyde and o-methoxy cinnamaldehyde.

scholarly journals Isolation and Characterizations of new alkaloid 3-deoxy- 3, 11-epoxy cephalotaxine from Clitoria ternatea

2019 ◽  
Vol 9 (4-A) ◽  
pp. 458-462
Author(s):  
MANIVANNAN - RAJAMANICKAM
Keyword(s):  
Fungal Infections ◽  
Bioactive Compound ◽  
Inflammatory Activity ◽  
Clitoria Ternatea ◽  
E Coli ◽  
Fungal Strains ◽  
Anti Inflammatory ◽  
Isolated Compound ◽  
Anti Fungal ◽  
Dose Levels

The present study describes the isolation and structural elucidation of new alkaloid 3-deoxy-3, 11-epoxy cephalotaxine (1) from the flowers of C. ternatea. It was isolated by careful column chromatographic separation of the crude extract on silica gel 60. The structure was established based on UV, IR, 1HNMR, 13CNMR and GC-MS spectroscopy methods. The antibacterial activity of various bacterial and fungal strains and anti-inflammatory activities of the isolated compound and its crude methanol extract was studied. The highest zone of inhibition (13.0 and 12.0 mm) was shown by 1 at a dose of 200 µg/kg against E. coli and S. aureus strains and (16.0, 12.0 mm) against anti-fungal strains of C. albicans and A. flavus. The results indicated that at both dose levels (100 mg and 200 mg / kg) of isolated compound 1 had significant anti-inflammatory activity from 2nd hour onwards. The bioactive compound isolated from this plant can be employed for antimicrobial activity, also for the treatment of various bacterial and fungal infections and to show pronounced anti-inflammatory effects after three hours of injection. Keywords: Clitoria ternatea, Alkaloid, 3-deoxy-3, 11-epoxy cephalotaxine, Anti-microbial activity, Anti-inflammatory activity 

MEKANISME KERJA ANDROGRAFOLIDA DARI SAMBILOTO SEBAGAI SENYAWA ANTIOKSIDAN

2021 ◽  
Vol 4 (1) ◽  
pp. 43
Author(s):  
Elvira Yunita
Keyword(s):  
Free Radicals ◽  
Mechanism Of Action ◽  
Superoxide Anion ◽  
Bioactive Compound ◽  
Ester Group ◽  
Superoxide Anions ◽  
Chemical Profile ◽  
Chain Reaction ◽  
Anti Cancer ◽  
Anti Inflammatory

Andrographolide is the main bioactive compound derived from sambiloto, Andrographis paniculata. Andrographolide compounds can potentially be used as phytopharmaca substances. Andrographolide has very broad pharmacological aspects, including anti-inflammatory, anticancer and anti-diabetic. The pharmacological aspects possessed by andrographolide are probably closely related to the chemical profile and the mechanism of action of andrographolide as an antioxidant in counteracting free radicals. Therefore, it is important to know the chemical profile and mechanism of action of andrographolide compounds as antioxidants to understand the mechanism of action of these compounds in dealing with various diseases. This study is based on a review of related literature. Based on the literature review, it was found that the mechanism of action of andrographolide as anti-cancer, anti-inflammatory and anti-dyslipidemia is closely related to the mechanism of action of this compound as an antioxidant. The unsaturated γ- lactone structure at C13 and C14 of andrographolide can neutralize superoxide anions. The double bond in this carbonyl ester group will affect the deprotonization of the H atone located at C15 so that the H atoms on C15 will be easily extracted by the highly reactive superoxide anion. Thus, andrographolide can stop the chain reaction of a radical molecule. This mechanism can cause andrographolide compounds to play a role in reducing the effects of free radicals in various diseases.

Naringenin: a potential bioactive compound and pathways of biosynthesis – a review

2021 ◽  
pp. 13-20
Keyword(s):  
Secondary Metabolites ◽  
Natural Compound ◽  
Higher Plants ◽  
Bioactive Compound ◽  
Effective Drug ◽  
Pharmacological Effects ◽  
Human Diet ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Plant Metabolite

Naringenin is a member of the flavonoid family. This natural compound represents a large proportion of secondary metabolites produced by higher plants and is a rich part of the human diet. Naringenin also has been used in the pharmaceutical and medical fields as an effective drug for anti-oxidative, anti-cancer, anti-obesity, and anti-inflammatory activities. Naringenin is also a typical plant metabolite, that has never been reported to be produced in prokaryotes. Recently, many papers reported that various members of the Streptomyces family, a genus of actinobacteria, had a novel pathway to produce naringenin. As a result, this review focuses on some clinical pharmacological effects and promising applications in the medical of naringenin, also its pathways of biosynthesis.

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