scholarly journals Human–Dromedary Camel Interactions and the Risk of Acquiring Zoonotic Middle East Respiratory Syndrome Coronavirus Infection

2014 ◽  
Vol 63 (1) ◽  
pp. 1-9 ◽  
Author(s):  
C. Gossner ◽  
N. Danielson ◽  
A. Gervelmeyer ◽  
F. Berthe ◽  
B. Faye ◽  
...  
Keyword(s):  
Middle East ◽  
Middle East Respiratory Syndrome ◽  
Dromedary Camel ◽  
Coronavirus Infection

scholarly journals Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia, 2014–2015

2017 ◽  
Vol 6 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Maged Gomaa Hemida ◽  
Abdulmohsen Alnaeem ◽  
Daniel KW Chu ◽  
Ranawaka APM Perera ◽  
Samuel MS Chan ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Longitudinal Study ◽  
Middle East ◽  
Middle East Respiratory Syndrome ◽  
Dromedary Camel ◽  
Coronavirus Infection

scholarly journals Current understanding of middle east respiratory syndrome coronavirus infection in human and animal models

2018 ◽  
Vol 10 (S9) ◽  
pp. S2260-S2271 ◽  
Author(s):  
Yanqun Wang ◽  
Jing Sun ◽  
Airu Zhu ◽  
Jingxian Zhao ◽  
Jincun Zhao
Keyword(s):  
Middle East ◽  
Animal Models ◽  
Middle East Respiratory Syndrome ◽  
Current Understanding ◽  
Coronavirus Infection

scholarly journals Passive Immunotherapy with Dromedary Immune Serum in an Experimental Animal Model for Middle East Respiratory Syndrome Coronavirus Infection

2015 ◽  
Vol 89 (11) ◽  
pp. 6117-6120 ◽  
Author(s):  
Jincun Zhao ◽  
Ranawaka A. P. M. Perera ◽  
Ghazi Kayali ◽  
David Meyerholz ◽  
Stanley Perlman ◽  
...  
Keyword(s):  
Middle East ◽  
Pulmonary Infection ◽  
Serum Antibody ◽  
Case Fatality ◽  
Immune Serum ◽  
Middle East Respiratory Syndrome ◽  
Specific Therapy ◽  
Passive Immunotherapy ◽  
Coronavirus Infection ◽  
Kinetics Of

ABSTRACTMiddle East respiratory syndrome (MERS) is a highly lethal pulmonary infection. Serum from convalescent MERS patients may provide some benefit but is not readily available. In contrast, nearly all camels in the Middle East have been infected with MERS-CoV. Here, we show that sera obtained from MERS-immune camels augment the kinetics of MERS-CoV clearance and reduce the severity of pathological changes in infected lungs, with efficacy proportional to the titer of MERS-CoV-neutralizing serum antibody.IMPORTANCEMiddle East respiratory syndrome, caused by a coronavirus, is highly lethal, with a case fatality rate of 35 to 40%. No specific therapy is available, and care is generally supportive. One promising approach is passive administration of sera from convalescent human MERS patients or other animals to exposed or infected patients. The vast majority of, if not all, camels in the Middle East have been infected with MERS-CoV, and some contain high titers of antibody to the virus. Here, we show that this antibody is protective if delivered either prophylactically or therapeutically to mice infected with MERS-CoV, indicating that this may be a useful intervention in infected patients.

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