Immunological selection and monitoring of patients undergoing pig kidney transplantation

2021 ◽  
Author(s):  
Aaron C.K. Lucander ◽  
Huy Nguyen ◽  
Jeremy B. Foote ◽  
David K.C. Cooper ◽  
Hidetaka Hara
Keyword(s):  
Kidney Transplantation ◽  
Pig Kidney

scholarly journals Continuous Normothermic Ex Vivo Kidney Perfusion Improves Graft Function in Donation After Circulatory Death Pig Kidney Transplantation

2017 ◽  
Vol 101 (4) ◽  
pp. 754-763 ◽  
Author(s):  
J. Moritz Kaths ◽  
Juan Echeverri ◽  
Yi Min Chun ◽  
Jun Yu Cen ◽  
Nicolas Goldaracena ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Ex Vivo ◽  
Graft Function ◽  
Donation After Circulatory Death ◽  
Pig Kidney ◽  
Kidney Perfusion ◽  
Circulatory Death

scholarly journals Bringing Home The Bacon: Update on The State of Kidney Xenotransplantation

2018 ◽  
Vol 45 (1-3) ◽  
pp. 254-259 ◽  
Author(s):  
David K.C. Cooper ◽  
H. Iwase ◽  
L. Wang ◽  
T. Yamamoto ◽  
Qi Li ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Kidney Transplantation ◽  
Graft Survival ◽  
Cellular Response ◽  
Genetic Manipulation ◽  
Immunosuppressive Agents ◽  
Cross Reactivity ◽  
Genetically Engineered ◽  
Kidney Graft ◽  
Pig Kidney

Background: There is a continuing critical shortage of organs from deceased human donors for transplantation, particularly for patients awaiting kidney transplantation. Efforts are being made to resolve the donor kidney shortage by the transplantation of kidneys from genetically-engineered pigs. Summary: This review outlines the pathobiological barriers to pig organ xenotransplantation in primates, which include (i) antibody-dependent complement-mediated rejection, (ii) a T cell-mediated elicited antibody and cellular response, (iii) coagulation dysregulation between pigs and primates, and (iv) a persistent inflammatory response. As a result of increasing genetic manipulation of the pig and the introduction of novel immunosuppressive agents, pig kidney graft survival has increased from minutes to months, and even to >1 year in some cases. Aspects of the selection of the patients for a first clinical trial are discussed. Although there would appear to be some cross-reactivity between anti-human leukocyte antigen (HLA) antibodies and swine leukocyte antigens expressed in pigs, some HLA-sensitized patients will be at no disadvantage if they receive a pig kidney. Furthermore, the current limited evidence is that, even if the patient becomes sensitized to pig antigens (after a pig organ transplant), this would not be detrimental to a subsequent allotransplant. The potential risk of infection with a pig microorganism, and the function of a pig kidney in a primate are also discussed. Key Message: The recent encouraging results of pig kidney transplantation in nonhuman primates suggest the likelihood of a successful (and safe) initial clinical trial, with graft survival for months or possibly years.

scholarly journals Pig Kidney Transplantation: An Up-To-Date Guideline

2012 ◽  
Vol 49 (3-4) ◽  
pp. 121-129 ◽  
Author(s):  
M. Golriz ◽  
H. Fonouni ◽  
A. Nickkholgh ◽  
M. Hafezi ◽  
C. Garoussi ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Pig Kidney

scholarly journals Physiologic Aspects of Pig Kidney Transplantation in Nonhuman Primates

2018 ◽  
Vol 68 (5) ◽  
pp. 332-340 ◽  
Author(s):  
Hayato Iwase ◽  
Edwin C Klein ◽  
David KC Cooper
Keyword(s):  
Kidney Transplantation ◽  
Nonhuman Primates ◽  
Pig Kidney

Miniature swine and hDAF pig kidney transplantation in baboons treated with a nonmyeloablative regimen and CD154 blockade

2001 ◽  
Vol 33 (1-2) ◽  
pp. 716 ◽  
Author(s):  
L Bühler ◽  
K Yamada ◽  
I Alwayn ◽  
H Kitamura ◽  
M Basker ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Miniature Swine ◽  
Pig Kidney

scholarly journals Oral Preconditioning of Donors After Brain Death With Calcineurin Inhibitors vs. Inhibitors of Mammalian Target for Rapamycin in Pig Kidney Transplantation

2020 ◽  
Vol 11 ◽  
Author(s):  
Sepehr Abbasi Dezfouli ◽  
Mohammadsadegh Nikdad ◽  
Omid Ghamarnejad ◽  
Elias Khajeh ◽  
Alireza Arefidoust ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Brain Death ◽  
Calcineurin Inhibitors ◽  
Pig Kidney
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