Peritoneal dissolved oxygen and function of encapsulated adult porcine islets transplanted in streptozotocin diabetic mice

2021 ◽  
Author(s):  
Fernie Mitchelson ◽  
Susan A. Safley ◽  
Kereen Gordon ◽  
Collin J. Weber ◽  
Athanassios Sambanis
Keyword(s):  
Dissolved Oxygen ◽  
Diabetic Mice ◽  
Porcine Islets ◽  
And Function

scholarly journals Low-Dose Radiation Activates Akt and Nrf2 in the Kidney of Diabetic Mice: A Potential Mechanism to Prevent Diabetic Nephropathy

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Xiao Xing ◽  
Chi Zhang ◽  
Minglong Shao ◽  
Qingyue Tong ◽  
Guirong Zhang ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Low Dose ◽  
X Rays ◽  
Diabetic Mice ◽  
Low Dose Radiation ◽  
Single Exposure ◽  
Akt Phosphorylation ◽  
And Function ◽  
Nrf2 Expression ◽  
Dose Radiation

Repetitive exposure of diabetic mice to low-dose radiation (LDR) at 25 mGy could significantly attenuate diabetes-induced renal inflammation, oxidative damage, remodeling, and dysfunction, for which, however, the underlying mechanism remained unknown. The present study explored the effects of LDR on the expression and function of Akt and Nrf2 in the kidney of diabetic mice. C57BL/6J mice were used to induce type 1 diabetes with multiple low-dose streptozotocin. Diabetic and age-matched control mice were irradiated with whole body X-rays at either single 25 mGy and 75 mGy or accumulated 75 mGy (25 mGy daily for 3 days) and then sacrificed at 1–12 h for examining renal Akt phosphorylation and Nrf2 expression and function. We found that 75 mGy of X-rays can stimulate Akt signaling pathway and upregulate Nrf2 expression and function in diabetic kidneys; single exposure of 25 mGy did not, but three exposures to 25 mGy of X-rays could offer a similar effect as single exposure to 75 mGy on the stimulation of Akt phosphorylation and the upregulation of Nrf2 expression and transcription function. These results suggest that single 75 mGy or multiple 25 mGy of X-rays can stimulate Akt phosphorylation and upregulate Nrf2 expression and function, which may explain the prevention of LDR against the diabetic nephropathy mentioned above.

Xenografts of porcine islets immunoprotected in hollow fibres reduce the incidence of diabetes in non-obese diabetic mice

Diabetologia ◽  
1996 ◽  
Vol 39 (5) ◽  
pp. 523-529 ◽  
Author(s):  
L. Chaillous ◽  
S. Darquy ◽  
S. Maugendre ◽  
A. -S. Rivereau ◽  
G. Reach ◽  
...  
Keyword(s):  
Diabetic Mice ◽  
Hollow Fibres ◽  
Porcine Islets

Long-Term Metabolic Control of Autoimmune Diabetes in Spontaneously Diabetic Nonobese Diabetic Mice by Nonvascularized Microencapsulated Adult Porcine Islets

2009 ◽  
Vol 88 (2) ◽  
pp. 160-169 ◽  
Author(s):  
Hong Cui ◽  
Carol Tucker-Burden ◽  
Sean M. D. Cauffiel ◽  
Adrienne K. Barry ◽  
Neal N. Iwakoshi ◽  
...  
Keyword(s):  
Metabolic Control ◽  
Autoimmune Diabetes ◽  
Diabetic Mice ◽  
Porcine Islets ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

Organoid optimization: Engineering a better cell therapy to treat type 1 diabetes

2020 ◽  
Vol 12 (526) ◽  
pp. eaba2909
Author(s):  
Jessica D. Weaver
Keyword(s):  
Type 1 Diabetes ◽  
Cell Therapy ◽  
Diabetic Mice ◽  
Subcutaneous Space ◽  
And Function

Islet organoids reaggregated in endothelialized collagen constructs improve engraftment and function in the subcutaneous space in diabetic mice.

Transplantation of Microencapsulated Syngeneic and Xenogeneic (Neonatal Porcine) Islets in Nonobese Diabetic Mice

1998 ◽  
Vol 30 (2) ◽  
pp. 500 ◽  
Author(s):  
Z Ao ◽  
W.L Suarez-Pinzon ◽  
R.V Rajotte ◽  
G.S Korbutt ◽  
M Flashner ◽  
...  
Keyword(s):  
Diabetic Mice ◽  
Porcine Islets ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice ◽  
Neonatal Porcine Islets

scholarly journals Impact of Dissolved Oxygen during UV-Irradiation on the Chemical Composition and Function of CHO Cell Culture Media

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0150957 ◽  
Author(s):  
Sarah M. Meunier ◽  
Biljana Todorovic ◽  
Emma V. Dare ◽  
Afroza Begum ◽  
Simon Guillemette ◽  
...  
Keyword(s):  
Cell Culture ◽  
Chemical Composition ◽  
Dissolved Oxygen ◽  
Uv Irradiation ◽  
Culture Media ◽  
Cho Cell ◽  
Cell Culture Media ◽  
Cho Cell Culture ◽  
And Function

The role of dissolved oxygen and function of agitation in hyaluronic acid fermentation

2006 ◽  
Vol 32 (3) ◽  
pp. 239-243 ◽  
Author(s):  
Wei-Chih Huang ◽  
Shu-Jen Chen ◽  
Teh-Liang Chen
Keyword(s):  
Hyaluronic Acid ◽  
Dissolved Oxygen ◽  
Acid Fermentation ◽  
And Function
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