Effect of TNF-alpha blockade on coagulopathy and endothelial cell activation in xenoperfused porcine kidneys

2015 ◽  
Vol 22 (4) ◽  
pp. 284-294 ◽  
Author(s):  
Wolf Ramackers ◽  
Johannes Klose ◽  
Andreas Tiede ◽  
Sonja Werwitzke ◽  
Dennis Rataj ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Activation ◽  
Tnf Alpha ◽  
Endothelial Cell Activation ◽  
Alpha Blockade

PRODUCTION OF CYTOKINES (TNF-ALPHA, IL-1-BETA) AND ENDOTHELIAL CELL ACTIVATION IN HUMAN LIVER ALLOGRAFT REJECTION1

1993 ◽  
Vol 55 (2) ◽  
pp. 329-334 ◽  
Author(s):  
MATTHIAS W. HOFFMANN ◽  
KURT WONIGEIT ◽  
GUSTAV STEINHOFF ◽  
HILDEGARD HERZBECK ◽  
HANS-DIETER FLAD ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Human Liver ◽  
Cell Activation ◽  
Tnf Alpha ◽  
Endothelial Cell Activation ◽  
Liver Allograft

scholarly journals beta-Naphthoflavone protects from peritonitis by reducing TNF-alpha-induced endothelial cell activation

2015 ◽  
Vol 102 ◽  
pp. 192-199 ◽  
Author(s):  
Sheng-Yao Hsu ◽  
Je-Wen Liou ◽  
Tsung-Lin Cheng ◽  
Shih-Yi Peng ◽  
Chi-Chen Lin ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Activation ◽  
Tnf Alpha ◽  
Endothelial Cell Activation

scholarly journals Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria

2020 ◽  
Vol 14 (7) ◽  
pp. e0007656
Author(s):  
João Conrado Khouri Dos-Santos ◽  
João Luiz Silva-Filho ◽  
Carla C. Judice ◽  
Ana Carolina Andrade Vitor Kayano ◽  
Júlio Aliberti ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Cell Activation ◽  
Endothelial Cell Activation ◽  
Plasmodium Vivax Malaria

scholarly journals Signs of sympathetic and endothelial cell activation in the skin of patients with restless legs syndrome

2021 ◽  
Author(s):  
Melanie Bergmann ◽  
Anna Heidbreder ◽  
Ambra Stefani ◽  
Cecilia Raccagni ◽  
Elisabeth Brandauer ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Restless Legs Syndrome ◽  
Cell Activation ◽  
Endothelial Cell Activation ◽  
Restless Legs

OR17 Heme oxygenase-1 modulates HLA class I antibody-dependent endothelial cell activation

2015 ◽  
Vol 76 ◽  
pp. 15
Author(s):  
Eva Zilian ◽  
Hendry Saragih ◽  
Oliver Hiller ◽  
Abid Aljabri ◽  
Constanca Figueiredo ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Heme Oxygenase ◽  
Cell Activation ◽  
Hla Class I ◽  
Class I ◽  
Heme Oxygenase 1 ◽  
Endothelial Cell Activation

scholarly journals Dengue Virus Induces the Expression and Release of Endocan from Endothelial Cells by an NS1–TLR4-Dependent Mechanism

2021 ◽  
Vol 9 (6) ◽  
pp. 1305
Author(s):  
Carlos Alonso Domínguez-Alemán ◽  
Luis Alberto Sánchez-Vargas ◽  
Karina Guadalupe Hernández-Flores ◽  
Andrea Isabel Torres-Zugaide ◽  
Arturo Reyes-Sandoval ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Mrna Expression ◽  
Cell Lines ◽  
Cell Activation ◽  
Dengue Infection ◽  
Elevated Serum ◽  
Fold Increase ◽  
Endothelial Cell Activation ◽  
Stimulation Of

A common hallmark of dengue infections is the dysfunction of the vascular endothelium induced by different biological mechanisms. In this paper, we studied the role of recombinant NS1 proteins representing the four dengue serotypes, and their role in promoting the expression and release of endocan, which is a highly specific biomarker of endothelial cell activation. We evaluated mRNA expression and the levels of endocan protein in vitro following the stimulation of HUVEC and HMEC-1 cell lines with recombinant NS1 proteins. NS1 proteins increase endocan mRNA expression 48 h post-activation in both endothelial cell lines. Endocan mRNA expression levels were higher in HUVEC and HMEC-1 cells stimulated with NS1 proteins than in non-stimulated cells (p < 0.05). A two-fold to three-fold increase in endocan protein release was observed after the stimulation of HUVECs or HMEC-1 cells with NS1 proteins compared with that in non-stimulated cells (p < 0.05). The blockade of Toll-like receptor 4 (TLR-4) signaling on HMEC-1 cells with an antagonistic antibody prevented NS1-dependent endocan production. Dengue-infected patients showed elevated serum endocan levels (≥30 ng/mL) during early dengue infection. High endocan serum levels were associated with laboratory abnormalities, such as lymphopenia and thrombocytopenia, and are associated with the presence of NS1 in the serum.

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