Biomimetic analyses of interactions between macrophages and palmar fascia myofibroblasts derived from Dupuytren's disease reveal distinct inflammatory cytokine responses

2021 ◽  
Author(s):  
Brianna C. Gonga‐Cavé ◽  
Ana Maria Pena Diaz ◽  
David B. O'Gorman
Keyword(s):  
Inflammatory Cytokine ◽  
Dupuytren’S Disease ◽  
Palmar Fascia ◽  
Dupuytren's Disease ◽  
Cytokine Responses

scholarly journals An effectiveness evaluation of the palmar fascia irradiation of patients suffering from Dupuytren’s disease

2017 ◽  
Vol 67 (3) ◽  
pp. 162-167 ◽  
Author(s):  
Tomasz Latusek ◽  
Leszek Miszczyk ◽  
Grzegorz Gierlach ◽  
Piotr Zając
Keyword(s):  
Dupuytren’S Disease ◽  
Effectiveness Evaluation ◽  
Palmar Fascia ◽  
Dupuytren's Disease

scholarly journals Dupuytren'S Contracture; Increased Cellularity — Proliferation, is There Equality?

2005 ◽  
Vol 94 (1) ◽  
pp. 71-75
Author(s):  
M. Forsman ◽  
L. Kallioinen ◽  
M. Kallioinen ◽  
J. Ryhänen
Keyword(s):  
Inflammatory Process ◽  
Dupuytren’S Disease ◽  
Palmar Fascia ◽  
Ki 67 ◽  
Dupuytren's Disease ◽  
Chronic Inflammatory Process ◽  
Proliferative Phase ◽  
Palmar Aponeurosis ◽  
Histological Characteristics ◽  
Control Samples

Background: Dupuytren's disease is a chronic inflammatory process which causes contractures of the fingers by shortening and thickening the palmar fascia. During the proliferative phase, fibroblasts transform into myofibroblasts apparently under the influence of several different factors. The disease usually develops slowly, but in some patients it tends to develop aggressively. The pathogenesis of Dupuytren's disease remains unsolved. In this study, we analyzed some histological characteristics that seem to predict rapid recurrence. Material and Methods: 21 patients were divided into two groups. In 11 patients the disease was classified as aggressive because it had recurred within two years after an operation. In 10 cases it was non-aggressive, as no recurrence had been seen. Five control samples were taken from healthy palmar aponeurosis. The differences in cellularity, collagen, Ki-67, MSA, alpha-SMA and tenascin between the specimens were analyzed using immunohistochemistry. Results: Alpha-SMA and Ki-67 were present more often in the aggressive specimens. Immunohistochemical stainings for macrophages and lymphocytes were negative. Conclusion: There may be differences in the histology and/or immunohistochemical appearance of pathological palmar connective tissue cords in aggressive and normal Dupuytren's disease. Further studies are needed to elucidate the pathogenesis of this disease.

scholarly journals Periostin differentially induces proliferation, contraction and apoptosis of primary Dupuytren's disease and adjacent palmar fascia cells

2009 ◽  
Vol 315 (20) ◽  
pp. 3574-3586 ◽  
Author(s):  
Linda Vi ◽  
Lucy Feng ◽  
Rebecca D. Zhu ◽  
Yan Wu ◽  
Latha Satish ◽  
...  
Keyword(s):  
Dupuytren’S Disease ◽  
Palmar Fascia ◽  
Dupuytren's Disease

Dupuytren’s disease

2011 ◽  
Author(s):  
Peter Burge
Keyword(s):  
Surgical Treatment ◽  
Steroid Injection ◽  
Treatment Options ◽  
Genetic Component ◽  
Dupuytren’S Disease ◽  
Palmar Fascia ◽  
Dupuytren's Disease ◽  
Collagenase Injection ◽  
Operative Complications ◽  
Non Surgical Treatment

♦ Dupuytren’s disease is characterised by contracture of a finger resulting from thickening and shortening of the palmar fascia♦ A genetic component to the aetiology is apparent, smoking, alcohol and diabetes can increase the risk♦ The pathogenesis of Dupuytren’s disease remains elusive♦ Non-surgical treatment options include splintage, steroid injection and collagenase injection♦ Surgery cannot cure the disease but can straighten bent digits and minimize recurrence♦ Operative methods can be considered with regards to incision, management of the diseased fascia and closure techniques♦ Operative complications include injury of digital nerves and arteries

An Investigation into the Role of Inflammatory Cells in Dupuytren’s Disease

1991 ◽  
Vol 16 (3) ◽  
pp. 267-271 ◽  
Author(s):  
J. G. ANDREW ◽  
S. M. ANDREW ◽  
A. ASH ◽  
B. TURNER
Keyword(s):  
Inflammatory Cells ◽  
Dupuytren’S Disease ◽  
Dupuytren’S Contracture ◽  
Palmar Fascia ◽  
Dupuytren's Disease ◽  
Dupuytren's Contracture ◽  
Microvascular Changes ◽  
Macrophage Marker ◽  
Fibrotic Diseases

An immunohistochemical study was performed on nodules excised from the palmar fascia of patients with Dupuytren’s contracture. In cellular nodules, antibodies to actin (used as a marker for myofibroblasts), desmin, vimentin, Mac 387 (a macrophage marker) and leucocyte common antigen were used. A correlation was demonstrated between the numbers of macrophages and the presence of myofibroblasts. The presence of myofibroblasts is generally considered to indicate the active stage of the disease. Inflammatory cells other than macrophages were largely absent from the nodules, although lymphocytes were frequent in the tissue around the nodules. Microvascular changes were prominent in the nodules and pericyte proliferation was observed around occluded capillaries. Release of growth factors from macrophages may be important in Dupuytren’s contracture, as is the case in other fibrotic diseases. The possible role of macrophages in the aetiology of Dupuytren’s disease is discussed.

scholarly journals Connective Tissue Degeneration: Mechanisms of Palmar Fascia Degeneration (Dupuytren’s Disease)

2016 ◽  
Vol 2 (3) ◽  
pp. 133-140 ◽  
Author(s):  
S. Karkampouna ◽  
M. Kreulen ◽  
M. C. Obdeijn ◽  
P. Kloen ◽  
A. L. Dorjée ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Dupuytren’S Disease ◽  
Palmar Fascia ◽  
Dupuytren's Disease ◽  
Tissue Degeneration

Oestrogen and Progesterone Hormone Receptors in Dupuytren’s Disease

1986 ◽  
Vol 11 (3) ◽  
pp. 463-464
Author(s):  
F. M. HANKIN ◽  
J. ECKENRODE ◽  
D. S. LOUIS
Keyword(s):  
Hormone Receptors ◽  
Steroid Hormone ◽  
Progesterone Receptors ◽  
Dupuytren’S Disease ◽  
Sex Steroid ◽  
Palmar Fascia ◽  
Hormone Metabolism ◽  
Dupuytren's Disease ◽  
Fibrotic Process ◽  
Specific Receptors

Dupuytren’s disease is associated with alcoholism and chronic liver disease, conditions frequently associated with deranged steroid hormone metabolism. The possible influence of endogenous sex steroid hormones on the development of Dupuytren’s disease has therefore been investigated. An analysis of diseased palmar fascia for oestrogen and progesterone receptors was undertaken in fifteen patients. Hormone specific receptors were not found in the palmar fascia of our patients with Dupuytren’s disease, thus suggesting that other mechanisms or factors contribute to the pathogenesis of this fibrotic process.

The Microanatomy of Dupuytren's Contracture

HAND ◽  
1982 ◽  
Vol os-14 (3) ◽  
pp. 215-236 ◽  
Author(s):  
D. A. Mcgrouther
Keyword(s):  
Fibrous Tissue ◽  
Three Dimensional ◽  
Dupuytren’S Disease ◽  
Dimensional System ◽  
Stress Concentrations ◽  
Palmar Fascia ◽  
Dupuytren's Disease ◽  
Joint Contractures ◽  
Normal Hand ◽  
Three Dimensional System

The palmar fascial ligaments have been examined by microdissection using an operating microscope in fresh and preserved cadaveric hands. The palmar fascia is seen to be a precise three dimensional system of skin ligaments having discreet transverse, longitudinal and vertical fibre systems. In the normal hand there is relative motion between the ligament systems on movement. The longitudinal fibres provide a system of skin anchorage which operates irrespective of the position of the underlying joints and acts particularly to resist shearing forces in gripping. The distribution of the lesions of Dupuytren's Disease has been recorded in a series of clinical cases; nodules, skin pits, distortion of the palmar creases, cords and joint contractures, and the pathogenesis of the disease is related to the anatomy of the palmar ligaments. The disease is described as a process of contracture along anatomical pathways. A hypothesis for the development of Dupuytren's Disease is presented whereby the loss of normal motion between palmar fascial ligaments gives rise on use of the hand to stress concentrations which stimulate fibrous tissue deposition and contracture.

Sign in / Sign up

Export Citation Format

Share Document