scholarly journals Variants in genes belonging to the fibroblast growth factor family are associated with lower extremity amputation in non-Hispanic whites: Findings from the chronic renal insufficiency cohort study

2016 ◽  
Vol 24 (4) ◽  
pp. 705-711
Author(s):  
Jayanta Gupta ◽  
Nandita Mitra ◽  
Raymond R. Townsend ◽  
Michael Fischer ◽  
Jeffrey R. Schelling ◽  
...  
Keyword(s):  
Cohort Study ◽  
Growth Factor ◽  
Renal Insufficiency ◽  
Lower Extremity ◽  
Fibroblast Growth Factor ◽  
Chronic Renal Insufficiency ◽  
Lower Extremity Amputation ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor Family ◽  
Extremity Amputation

scholarly journals Fibroblast Growth Factor 23 and Anemia in the Chronic Renal Insufficiency Cohort Study

2017 ◽  
Vol 12 (11) ◽  
pp. 1795-1803 ◽  
Author(s):  
Rupal Mehta ◽  
Xuan Cai ◽  
Alexander Hodakowski ◽  
Jungwha Lee ◽  
Mary Leonard ◽  
...  
Keyword(s):  
Cohort Study ◽  
Growth Factor ◽  
Renal Insufficiency ◽  
Fibroblast Growth Factor ◽  
Chronic Renal Insufficiency ◽  
Fibroblast Growth Factor 23 ◽  
Fibroblast Growth

Characterization of int-2: a member of the fibroblast growth factor family

1990 ◽  
Vol 1990 (Supplement 13) ◽  
pp. 87-96 ◽  
Author(s):  
C. DICKSON ◽  
P. ACLAND ◽  
R. SMITH ◽  
M. DIXON ◽  
R. DEED ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor Family

scholarly journals Decoding the Genetic Alterations in Genes of Fibroblast Growth Factor Family and Their Possible Association with HNSCC

2021 ◽  
pp. 698-710
Author(s):  
A. Akshaya ◽  
J. Vijayashree Priyadharsini ◽  
A. S. Smiline Girija ◽  
P. Sankar Ganesh ◽  
Nidhi Poddar
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Demographic Data ◽  
Primary Tumour ◽  
Genetic Alterations ◽  
Fibroblast Growth ◽  
Heparin Binding ◽  
Fibroblast Growth Factor Family ◽  
Significant Difference ◽  
Cancer Phenotypes

Introduction: HNSCC is a type of cancer in the oral and pharynx region. Several mutations/variations are observed in these cancer phenotypes. Fibroblast growth factor belongs to the family of heparin binding growth factors. FGFs are multifunctional proteins with a wide variety of effects; they are most commonly mitogens. Their expression pattern correlates with invasion of HNSCC. Aim: To assess the genetic alterations in genes of the fibroblast growth factor family and their association with HNSCC. Materials and Methods: The demographic data and samples of 528 HNSCC patients was collected from the cBioportal database. Oncoprint analysis was done to assess the amplification and genetic alterations of the members of the FGF gene family. String analysis was performed to evaluate the protein-protein interaction. The information about previous reported mutation and correlation with novel and reported mutation was obtained using GnomAD analysis. Results and Discussion: FGF3,4 and 19 genes showed maximum variation (25%). FGF4 and FGF19 genes showed maximum amplification in addition to deletion mutation. Excitingly FGF3, FGF4 and FGF19 genes showed similar amplification patterns in most of the HNSCC patients. Statistical significant difference in the gene expression of FGF3 9.578 x 10-3 observed between normal and primary tumour. S.  Findings showed many novel mutations and also 4 reported mutations ie:FGF1, FGF12, FGF20, FGF21 Conclusion: Our present study concludes that more evidence is required to confirm their association with HNSCC.

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