Hyaluronic acid dressing (Healoderm) in the treatment of diabetic foot ulcer: A prospective, randomized, placebo-controlled, single-center study

2016 ◽  
Vol 24 (3) ◽  
pp. 581-588 ◽  
Author(s):  
Moses Lee ◽  
Seung Hwan Han ◽  
Woo Jin Choi ◽  
Kwang Ho Chung ◽  
Jin Woo Lee
Keyword(s):  
Hyaluronic Acid ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Single Center ◽  
Single Center Study ◽  
Center Study

Collagen dressing in the treatment of diabetic foot ulcer: A prospective, randomized, placebo-controlled, single-center study

2019 ◽  
Vol 156 ◽  
pp. 107861 ◽  
Author(s):  
Kwang Hwan Park ◽  
Jae Bum Kwon ◽  
Jae Han Park ◽  
Ju Cheol Shin ◽  
Seung Hwan Han ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Single Center ◽  
Single Center Study ◽  
Center Study

scholarly journals The Changes of Trends in the Diagnosis and Treatment of Diabetic Foot Ulcer over a 10-Year Period: Single Center Study

2018 ◽  
Vol 42 (4) ◽  
pp. 308 ◽  
Author(s):  
Choong Hee Kim ◽  
Jun Sung Moon ◽  
Seung Min Chung ◽  
Eun Jung Kong ◽  
Chul Hyun Park ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Diagnosis And Treatment ◽  
Single Center ◽  
Single Center Study ◽  
Center Study

The effect of a multidisciplinary outpatient team approach on outcomes in diabetic foot care: a single center study

2020 ◽  
Vol 60 (6) ◽  
Author(s):  
Eline Huizing ◽  
Michiel A. Schreve ◽  
Willemijn Kortmann ◽  
Jan P. Bakker ◽  
Jean-Paul P. M. de Vries ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Team Approach ◽  
Single Center ◽  
Foot Care ◽  
Single Center Study ◽  
Center Study

scholarly journals Hyaluronic Acid Dressing in the Treatment of Diabetic Foot Ulcer

2016 ◽  
Vol 1 (1) ◽  
pp. 2473011416S0007
Author(s):  
Yeokgu Hwang ◽  
Yoo Jung Park ◽  
Dong-Woo Shim ◽  
Moses Lee ◽  
Kwang Hwan Park ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer

scholarly journals Advance-Platelet Rich Fibrin and Hyaluronic Acid Combination Improves Interleukin-6 and Granulation Index in Diabetic Foot Ulcer Patients

2021 ◽  
Vol 13 (2) ◽  
pp. 170-7
Author(s):  
Ronald Winardi Kartika ◽  
Idrus Alwi ◽  
Franciscus Dhyanagiri Suyatna ◽  
Em Yunir ◽  
Sarwono Waspadji ◽  
...  
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Interleukin 6 ◽  
Diabetic Foot ◽  
Healing Process ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Fibrin Gel ◽  
Platelet Rich Fibrin ◽  
Wound Protection

BACKGROUND: Diabetic foot ulcer (DFU) is the most common and threatening complication of Diabetes Mellitus (DM). Ideal wound dressing for DFU management should relieve symptoms, provide wound protection, and encourage healing. Advanced-Platelet Rich Fibrin (A-PRF) and Hyaluronic Acid (HA) have been proven to improve wound healing process. This study was aimed to demonstrate the ability of combination of A-PRF and HA in reducing inflammation and improving DFU tissue healing.METHODS: Twenty DFU subjects were involved in this study, and divided into two groups based on the topical fibrin gel treatment: A-PRF + HA group and A-PRF only group. A-PRF was obtained by peripheral blood centrifugation. A-PRF + HA was prepared by homogening A-PRF and AH with a ratio of 1:0.6. Interleukin-6 (IL-6) level, granulation index (GI), numeric pain score (NPS), and inflammation clinical symptoms (ICS) were assessed on day-0, 3, 7 and 14.RESULTS: Wound swabs’ IL-6 level on day-7 was found to be significantly lower in A-PRF + HA compared to A-PRF alone (p=0.041). The IL-6 level reduction also found to be significant higher either in wound swabs (day 0-7, p=0.015) or fibrin gel (day 0-3, p=0.049; day 0-7, p=0.034). A-PRF + HA treatment significantly increased the GI even since day-3 (p=0.043), with lower NPS (p<0.001), and ICS score.CONCLUSION: The combination of A-PRF and HA increases the GI in DFU healing by reducing the inflammation state which will induce the angiogenesis process, as well as reducing pain in DFU subjects better than A-PRF alone.KEYWORDS: inflammation, interleukin-6, wound healing, angiogenesis, proliferation 

A randomized, prospective, blinded, split-face, single-center study comparing polycaprolactone to hyaluronic acid for treatment of nasolabial folds

2015 ◽  
Vol 14 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Hassan Galadari ◽  
Daan van Abel ◽  
Khawla Al Nuami ◽  
Fatima Al Faresi ◽  
Ibrahim Galadari
Keyword(s):  
Hyaluronic Acid ◽  
Single Center ◽  
Single Center Study ◽  
Nasolabial Folds ◽  
Split Face ◽  
Center Study

scholarly journals Diabetic Foot Infections and Outcomes: A Single Center Study

2021 ◽  
Vol 3 (2) ◽  
pp. 64-69
Author(s):  
Derya Yapar ◽  
Özlem Akdogan ◽  
Murat Kendirci ◽  
Aysel Kocagül Çelikbas ◽  
Nurcan Baykam
Keyword(s):  
Diabetic Foot ◽  
Single Center ◽  
Diabetic Foot Infections ◽  
Single Center Study ◽  
Center Study

scholarly journals Hyaluronic Acid Accelerates VEGF and PDGF Release from Advance Platelet Rich Fibrin in Diabetic Foot Ulcer

2021 ◽  
Vol 13 (3) ◽  
pp. 332-6
Author(s):  
Ronald Winardi Kartika ◽  
Idrus Alwi ◽  
Franciscus Dhyanagiri Suyatna ◽  
Ferry Sandra ◽  
Em Yunir ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Growth Factor ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Vascular Endothelial ◽  
Platelet Rich Fibrin ◽  
Growth Factor Release ◽  
Endothelial Growth Factor ◽  
Factor Release

BACKGROUND: Hyaluronic acid (HA) is an essential component of extracellular matrix and mediates signaling in wound healing. HA could induce growth factor release from Advanced Platelet Rich Fibrin (A-PRF), including Vascular Endothelial Growth Factor (VEGF) and Platelet-derived Growth Factor (PDGF). However, concentrations of the released-VEGF and PDGF have not been clearly disclosed. Therefore, current study was conducted to measure the release of these growth factors in HA + A-PRF gel of diabetic foot ulcer (DFU) subjects.METHODS: Twenty DFU subjects were included in the study and treated with A-PRF or HA+A-PRF. A-PRF was derived from autologous peripheral blood and processed with low-speed centrifugation. HA was added with a ratio of 1:0.6. A-PRF or HA + A-PRF was applied topically on DFU. Upper tips of A-PRF or HA + A-PRF gels were collected on day 0, 3 and 7 for measurements of VEGF and PDGF concentrations with Enzyme-linked Immune-sorbent Assay (ELISA) methods.RESULTS: On day-3, both VEGF and PDGF concentrations of HA + A-PRF group were significantly higher than the VEGF (p=0.000) and PDGF (p=0.019) concentrations of A-PRF group. The VEGF and PDGF concentrations were continuously and significantly increased on day-7 of HA + A-PRF group, compared to the VEGF (p=0.000) and PDGF (p=0.004) concentrations of A-PRF group.CONCLUSION: Combination HA+A-PRF induces VEGF and PDGF release from A-PRF. A mixture of A-PRF and HA could be more effective than A-PRF alone for treatment of DFU.KEYWORDS: hyaluronic acid, advanced platelet rich fibrin, PRF, growth factor, VEGF, PDGF, diabetic foot ulcer

scholarly journals Clinical, Etiological, Anatomical, and Bacteriological Study of “Diabetic Foot” Patients: Results of a Single Center Study

Cureus ◽  
2018 ◽  
Author(s):  
Ashwinikumar Patil ◽  
Datta More ◽  
Anant Patil ◽  
Kishor A Jadhav ◽  
Myriam E Vijil Mejia ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Single Center ◽  
Bacteriological Study ◽  
Single Center Study ◽  
Center Study
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