Role of IL-17 and TGF-β in peritoneal adhesion formation after surgical trauma

2014 ◽  
Vol 22 (5) ◽  
pp. 631-639 ◽  
Author(s):  
Geng Wang ◽  
Ke Wu ◽  
Wei Li ◽  
Ende Zhao ◽  
Liang Shi ◽  
...  
Keyword(s):  
Adhesion Formation ◽  
Surgical Trauma ◽  
Peritoneal Adhesion ◽  
Peritoneal Adhesion Formation

Role of plasminogen activators in peritoneal adhesion formation

2002 ◽  
Vol 30 (2) ◽  
pp. 126-131 ◽  
Author(s):  
H. Sulaiman ◽  
L. Dawson ◽  
G. J. Laurent ◽  
G. J. Bellingan ◽  
S. E. Herrick
Keyword(s):  
Plasminogen Activator ◽  
Adhesion Formation ◽  
Tissue Type ◽  
Surgical Trauma ◽  
Wild Type ◽  
Post Injury ◽  
Peritoneal Adhesion ◽  
Type Plasminogen Activator ◽  
Peritoneal Adhesion Formation

Intra-abdominal adhesion formation is a major complication of serosal repair following surgery, ischaemia or infection, leading to conditions such as intestinal obstruction and infertility. It has been proposed that the persistence of fibrin, due to impaired plasminogen activator activity, results in the formation of adhesions between damaged serosal surfaces. This study aimed to assess the role of fibrinolysis in adhesion formation using mice deficient in either of the plasminogen activator proteases, tissue-type plasminogen activator (tPA) or urokinase-type plasminogen activator (uPA). We hypothesize that, following serosal injury, mice with decreased peritoneal fibrinolytic activity will be more susceptible to adhesion formation. Adhesion formation was induced in tPA- and uPA-deficient and wild-type mice following either surgical trauma to the serosa with haemorrhage and acute or chronic intraperitoneal inflammation. Adhesion formation was assessed from 1 to 4 weeks post-injury. Mice deficient in tPA were more susceptible to adhesion formation following both a surgical insult and a chronic inflammatory episode compared with uPA-deficient and wild-type mice. In addition, the time of maximal adhesion formation varied depending on the nature of the initial insult. It is proposed that the persistence of fibrin due to decreased tPA activity following surgery or chronic inflammation plays a major role in peritoneal adhesion formation.

The role of plasminogen activators in peritoneal adhesion formation

2002 ◽  
Vol 30 (1) ◽  
pp. A39-A39 ◽  
Author(s):  
H. Sulaiman ◽  
L. Dawson ◽  
G.J. Laurent ◽  
G. Bellingan ◽  
S.E. Herrick
Keyword(s):  
Adhesion Formation ◽  
Plasminogen Activators ◽  
Peritoneal Adhesion ◽  
Peritoneal Adhesion Formation

4. The role of mast cells in peritoneal adhesion formation

1992 ◽  
Vol 163 (6) ◽  
pp. 624
Author(s):  
S. Liebman ◽  
J.C. Langer ◽  
S. Sohal ◽  
J. Marshall ◽  
S.M. Collins
Keyword(s):  
Mast Cells ◽  
Adhesion Formation ◽  
Peritoneal Adhesion ◽  
Peritoneal Adhesion Formation

The role of oral fluvastatin on postoperative peritoneal adhesion formation in an experimental rat model

2018 ◽  
Vol 118 (6) ◽  
pp. 372-379 ◽  
Author(s):  
Yinzi Yue ◽  
Shuai Yan ◽  
Huan Li ◽  
Yang Zong ◽  
Jin Yue ◽  
...  
Keyword(s):  
Rat Model ◽  
Adhesion Formation ◽  
Peritoneal Adhesion ◽  
Peritoneal Adhesion Formation ◽  
Experimental Rat Model

The Role of Neutrophils in Peritoneal Adhesion Formation

1996 ◽  
Vol 61 (1) ◽  
pp. 143-146 ◽  
Author(s):  
Aamer Ar’Rajab ◽  
William Mileski ◽  
James T. Sentementes ◽  
Patricia Sikes ◽  
Richard B. Harris ◽  
...  
Keyword(s):  
Adhesion Formation ◽  
Peritoneal Adhesion ◽  
Peritoneal Adhesion Formation

scholarly journals Role of Mast Cells and Myofibroblasts in Human Peritoneal Adhesion Formation

2002 ◽  
Vol 236 (5) ◽  
pp. 593-601 ◽  
Author(s):  
Xiang Xu ◽  
Avraham Rivkind ◽  
Orit Pappo ◽  
Alon Pikarsky ◽  
Francesca Levi-Schaffer
Keyword(s):  
Mast Cells ◽  
Adhesion Formation ◽  
Peritoneal Adhesion ◽  
Peritoneal Adhesion Formation

The Role of Simvastatin on Postoperative Peritoneal Adhesion Formation in an Animal Model

2007 ◽  
Vol 39 (2) ◽  
pp. 98-102 ◽  
Author(s):  
Hasan Fehmi Kucuk ◽  
Levent Kaptanoglu ◽  
Necmi Kurt ◽  
Huseyin Uzun ◽  
Mehmet Eser ◽  
...  
Keyword(s):  
Animal Model ◽  
Adhesion Formation ◽  
Peritoneal Adhesion ◽  
Peritoneal Adhesion Formation

scholarly journals O-047. Analysis of the role of neutrophils in peritoneal adhesion formation

1997 ◽  
Vol 12 (Suppl_2) ◽  
pp. 22-23
Author(s):  
B. Vural ◽  
N.Z. Cantürk ◽  
N. Esen ◽  
I. Yücesoy ◽  
O. Özbay
Keyword(s):  
Adhesion Formation ◽  
Peritoneal Adhesion ◽  
Peritoneal Adhesion Formation

Role of mast cells in peritoneal adhesion formation

1993 ◽  
Vol 165 (1) ◽  
pp. 127-130 ◽  
Author(s):  
Shael M. Liebman ◽  
Jacob C. Langer ◽  
Jean S. Marshall ◽  
Stephen M. Collins
Keyword(s):  
Mast Cells ◽  
Adhesion Formation ◽  
Peritoneal Adhesion ◽  
Peritoneal Adhesion Formation
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