Minimal late radiation toxicity and transient early toxicity following postoperative definitive intent conformal radiation therapy (20 × 2.5 Gy) for canine apocrine gland anal sac adenocarcinoma

2021 ◽  
Author(s):  
Claire Williams ◽  
Magdalena Parys ◽  
Ian Handel ◽  
Juan Carlos Serra ◽  
Jessica Lawrence
Keyword(s):  
Radiation Therapy ◽  
Radiation Toxicity ◽  
Apocrine Gland ◽  
Conformal Radiation Therapy ◽  
Anal Sac ◽  
Early Toxicity

Conformal Radiation Therapy in Children Oncology

2015 ◽  
Vol 2 (1) ◽  
pp. 54-60
Author(s):  
V.P. Belova ◽  
◽  
I.V. Glekov ◽  
V.A. Grigorenko ◽  
M.V. Levchenko ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Conformal Radiation Therapy

scholarly journals Prognostic Value of Ki67 and Other Clinical and Histopathological Factors in Canine Apocrine Gland Anal Sac Adenocarcinoma

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1649
Author(s):  
Emanuela Maria Morello ◽  
Marzia Cino ◽  
Davide Giacobino ◽  
Arturo Nicoletti ◽  
Selina Iussich ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Vascular Invasion ◽  
Apocrine Gland ◽  
Regional Lymph Nodes ◽  
Disease Free Interval ◽  
Lymph Nodes Metastasis ◽  
Free Interval ◽  
Histologic Pattern ◽  
Anal Sac ◽  
Disease Free

Apocrine gland anal sac adenocarcinoma (AGASACA) is locally aggressive and highly metastatic to regional lymph nodes. The aim of this study was to evaluate the prognostic significance of Ki67 in surgically excised AGASACA. Prognostic impact of size, regional lymph nodes metastasis, hypercalcemia, histologic pattern, mitotic count, necrosis, inflammatory and lympho-vascular invasion, anisokaryosis and anisocytosis was also evaluated. Thirty-five dogs were included, twenty-four of which also had metastatic lymph nodes. When the entire population was evaluated, only metastatic disease spread to regional lymph nodes, and necrosis and inflammatory infiltration were correlated to prognosis. When only dogs with metastatic disease were evaluated, size, solid histologic pattern, presence of lymphatic and vascular invasion showed influence on prognosis. Ki67 index was not associated with survival time and disease free interval in any case. The results of this study showed that lymph nodes metastasis at diagnosis reduced disease free interval. Moreover, tumor size greater than 5.25 cm, presence of lymphatic and vascular invasion and a solid histologic pattern were associated with a shorter survival time in dogs with metastasis to regional lymph nodes. Ki67 expression was not significantly associated with prognosis, therefore it could not be considered as a prognostic factor in this tumor type, while the role of hypercalcemia remained unclear.

scholarly journals Inversed-Planned Respiratory Phase Gating in Lung Conformal Radiation Therapy

2017 ◽  
Vol 99 (2) ◽  
pp. 317-324 ◽  
Author(s):  
Arezoo Modiri ◽  
Pouya Sabouri ◽  
Xuejun Gu ◽  
Robert Timmerman ◽  
Amit Sawant
Keyword(s):  
Radiation Therapy ◽  
Conformal Radiation Therapy ◽  
Respiratory Phase
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